BrunetLab

Group Leader - Genome Biology Unit Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...

To all post-docs: The Genome Biology dept ‪@embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

The Anne West lab at Duke is hiring a postdoc to work on nuclear cell biology in neurogenesis. Please help me spread the word! Applications to west@neuro.duke.edu.

electron microscopy image of a C elegans on a yellow background

🧬June's most-read Genetics paper independently validates previous research showing that #CElegans can inherit learned pathogen avoidance: buff.ly/IFNoPF3

Have a paper people should see? See what our Editors look for: buff.ly/WiP1juL

Hallmarks of stem cell aging Aging disrupts core functions of somatic stem cells throughout the body, leading to impaired tissue maintenance and repair. We identify five key features of aged stem cells, highlighting how their dys...

Happy to share our review at Cell Stem Cell as part of their Hallmarks series. As always, a pleasure to work with friends and colleagues Anne Brunet (@brunetlab.bsky.social) and Peggy Goodell(@goodell-lab.bsky.social).

Hallmarks of stem cell aging: Cell Stem Cell www.cell.com/cell-stem-ce...

Hallmarks of stem cell aging As organisms age, somatic stem cells progressively lose their ability to sustain tissue homeostasis and support regeneration. Although stem cells are …

Excited to share our review on Hallmark of Stem Cell Aging! With Tom Rando and Peggy Goodell @goodell-lab.bsky.social!!

www.sciencedirect.com/science/arti...

Sleep need–dependent plasticity of a thalamic circuit promotes homeostatic recovery sleep Prolonged wakefulness leads to persistent, deep recovery sleep (RS). However, the neuronal circuits that mediate this process remain elusive. From a circuit screen in mice, we identified a group of th...

New collaborative study out with Mark Wu’s group identifies a thalamic reuniens-zona incerta circuit as both responsive to induced sleep deprivation and essential for mediating recovery sleep. Further perspective on this work follows./1
www.science.org/doi/epdf/10....

Nobel laureate on how Trump's cuts are hurting science Neuroscientist, biologist and 2021 Nobel Prize winner Ardem Patapoutian joined Midday Edition to talk about how the Trump administration's effort to cut back on science spending is impacting researche...

I spoke with Jade Hindmon, host of @kpbssandiego.bsky.social Midday Edition, about the consequences of the current administration’s cuts to science funding. Please share to help spread the word and raise awareness.
www.kpbs.org/podcasts/kpb...

1/n Fellow C elegans enthusiasts!

For those of you using WormCat for RNA seq pathway analysis, we are working on the 3.0 version. Comments on annotations/website welcome. Either PM here or let's talk at the Worm meeting in Davis. #Worm25 #celegans

Highlighting this new paper NOT by my lab, but by Andres Vidal-Gadea's lab: doi.org/10.7554/eLif...
#Celegans - more to say on this later 🧪

Atul Butte died yesterday.
The world lost a giant.
A big bear of a man.
With a huge smile.
With love for everyone.
With energy that could power a room.
I loved everything about Atul.
I loved how he was always happy.
I loved how excited he was about science and helping people.

THOMAS BLACKWELL Obituary (1957 - 2025-05-09) - Boston, MA - Boston Globe View THOMAS KEITH BLACKWELL's obituary, send flowers and sign the guestbook.

Sad to learn we lost Keith Blackwell, an unsung hero of the aging field. Keith showed rapamycin extends C. elegans lifespan, that mTORC2 has diet-dependent effects on aging, and linked together skn1 TOR splicing and aging.
www.legacy.com/us/obituarie...

Resilience and restoration from fasting-refeeding mediated by a nutrient-regulated linker histone Intermittent fasting and fasting-refeeding regimens can slow biological aging across taxa[1][1]. Shifts between fed and fasted states activate ancient nutrient-sensing pathways which alter cellular an...

Preprint alert @biorxivpreprint! We are excited to share our latest study led by @kkawamura13.bsky.social @annadiederich01.bsky.social in collaboration with & C. Demetriades Lab & @muellerrom.bsky.social Lab
www.biorxiv.org/content/10.1...

I'm giving a talk tomorrow morning about my book ("How We Age"). But the slides already feel out of date because 1) there are so many new stories in the field, and 2) science as we know it is being destroyed, so the pipeline from ideas to drugs will dry up soon. Sigh

A few days late, but I’m happy to post our recent publication on body-to-brain signaling regulation of memory in Nature Aging:

KODAMA goes spatial.
doi.org/10.1101/2025...
#spatialtranscriptomics #visium #visiumhd #seurat #giotto

Body-to-brain insulin and Notch signaling regulates memory through neuronal CREB activity - Nature Aging Zhou, Novak and colleagues identify that the Caenorhabditis elegans hypodermis, a peripheral liver-like metabolic tissue, regulates memory via insulin/IGF-1 and Notch signaling, and show that activati...

Online now!✨RESEARCH: Zhou, Novak et al show that the hypodermis regulates memory in C. elegans via insulin/IGF-1 and Notch signaling; activating this pathway rescues CREB-dependent memory in aged worms @ctmurphy1.bsky.social www.nature.com/articles/s43... rdcu.be/eo3Pd

I'm excited to announce that I'll be starting a lab at UCSF in the @ihgatucsf.bsky.social and @ucsf-epibiostat.bsky.social in July.

We'll work at the intersection of statistical genetics, population genetics, and machine learning.

I have an opportunity to hire a staff scientist for my lab. Looking for someone with outstanding skillset in ML/statistics, genomics applications; interest in mentoring, strong publication record, PD experience required.

Email CV to me+cc my assistant (see 'contact' on my website). Ad to follow.

YouTube video by CSHL Leading Strand Interview with Coleen Murphy

Memory loss in aging - what are the mechanisms and can they be reversed? A fascinating conversation with @ctmurphy1.bsky.social youtu.be/To5KFveFm9c?...

Congratulations to our Human Neural Circuitry team; bit.ly/4dEyX7Z publishes today in Science! This was the hardest challenge of my career, but one of the most rewarding, after years of rebuilding– & expanding my inpatient neuropsychiatry in the service of basic discovery bsky.app/profile/deis...

How neural stem cell therapy promotes brain repair after stroke In this review, Weber, Rust, and Tackenberg discuss the potential mechanisms by which neural stem/progenitor cell therapy can induce brain recovery after ischemic stroke. They argue that neural stem/p...

www.cell.com/stem-cell-re...

We—Nicolas @rohner.bsky.social, Lauren @lsaunders.bsky.social, Arica @abeisaw.bsky.social & Sepand @rastapopolus.bsky.social—are planning the first German #fish ( #zebrafish, #medaka, #killifish, others) #meeting for September 2026. If you're a PI & want info, get in touch!

YouTube video by Amanpour and Company Breakthrough Prize-Winning Biochemist on the Deadly Cost of Funding Cuts | Amanpour and Company

David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏

youtu.be/8YhJM6zxYDw?...

Clayton Baker

Minhoo Kim

Aaron Lemus (and Victor Ansere)

Ryan Lu

Benayoun lab team members Clayton Baker, Minhoo Kim, Aaron Lemus (with photobomb from Victor Ansere) and Ryan Lu rocking Poster session#1 at #AGE2025 in Anchorage! ❤️❤️ #USCLeonardDavis #EarlyCareer #ProudMentor

‘The first experiments produced just jaw-dropping results’ Stanford neuro-oncologist Michelle Monje is pursuing a cure for a deadly pediatric brain cancer – and reshaping our understanding of how cancer and brain development intersect.

🧪
#neurology
#neuroskyence
tinyurl.com/bp5d8386
Another beautiful example of NIH-SPONSORED bedside to bench and back to bedside work from an outstanding clinician scientist. This work is producing some of the most compelling responses to treatment in what is arguably the worst pediatric brain tumor.

Fueling the next phase of brain resilience: 2025 Catalyst Momentum Awards Four Stanford teams receive funding from the Knight Initiative for Brain Resilience to advance research

Congratulations to our 2025 Catalyst Momentum awardees! Their projects explore how sleep, inflammation, endocannabinoid metabolism, cellular stress, microglia, and other factors shape brain aging and resilience.

Learn more: brainresilience.stanford.edu/news/fueling...

Harvard University Harvard University is devoted to excellence in teaching, learning, and research, and to developing leaders who make a difference globally.

www.harvard.edu

Boston Has Worms (The Good Kind) Inside the world of C. elegans worms and the scientists who know them best.

It was so much fun to discuss why we do basic science.

"If we understand how biology works, then lots of useful applications will come out of it ... But honestly, that’s not the only thing that drives people. People are just curious, and they want to know how living systems work."

#Celegans 🧪🧬🪱

Interferon-γ orchestrates leptomeningeal anti-tumour response - Nature Independent of antigen presentation, migratory CCR7+ dendritic cells orchestrate the influx, proliferation and cytotoxic action of natural killer cells to control cancer cell growth in the leptomening...

I am pleased to share our recent publication, fruit of a wonderful collaboration with truly amazing colleagues @adrienneboire.bsky.social and @meningojan.bsky.social, whose work was a tour de force demonstrating that immunology in the brain is a different beast -> www.nature.com/articles/s41...

Systems consolidation reorganizes hippocampal engram circuitry Nature - A study shows that loss of memory precision associated with systems consolidation can be explained by neurogenesis-dependent reorganization of engram circuitry within the hippocampus over...

Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation.

rdcu.be/el18q

A short thread follows for those interested.

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