BrunetLab

Top left: Schematic derived from WormPaths showing methionine salvage and arginine-derived metabolic pathways. Information regarding gene level and H3K4me3 status from Control, sams-1 or sams-4 animals in basal or heat-shocked conditions is marked in legend. Data is from Godbole and colleagues eLife 2023. Bottom left: Schematic showing connections between SAM and PC synthesis to trafficking of PC to and within the mitochondria. Right: Transmission electron micrograph of normal mitochondria (blue, top) compared to those with low levels of the phospholipid phosphatidylcholine (pink, bottom) from C. elegans intestinal cells, showing collapse of the mitochondrial network and accumulation along the intestinal lumen. Image taken by Dr. Maria Ericsson

S-adenosylmethionine synthases (SAMS) have distinct roles in #StressResponse & #mitochondrial metabolism in #Celegans. @akw-lab.bsky.social &co show that SAMS-1 supports broad metabolic functions (e.g. PC synthesis), while SAMS-4 aids protein transmethylation @plosbiology.org 🧪 plos.io/4rvQvtt

Conference: Neurogenesis from development to adulthood in health and disease The adult brain consists of billions of neurons that show an unimaginable complexity in their structural diversity and functional connectivity allowing for a plethora of brain functions. Notably…

Interested in neural stem cells and neurogenesis throughout lifespan?

Exciting meeting in 2026 in Switzerland!!

neuro-unige.ch/news/csf-mee...

Congratulations Elphège!! 🤩🥂

Here is a copy of last year's Twitter thread explaining our preprint - jump to (21) for the new stuff 👀

Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function

now revised and journal accepted at www.science.org/doi/10.1126/...

🧵👇

Excellent commentary on transgenerational inheritance and the importance of rigor and reproducibility.

Subtitled: when a colleague drags and tries to throw you under the bus because they couldn't follow protocols

@ctmurphy1.bsky.social

Love this Insight by @steeltownworms.bsky.social on a series of @elife.bsky.social papers on what it takes to reproduce a phenomenon of transgenerationally transmitted learned pathogen avoidance in C. elegans. Thank you, Lesley!
elifesciences.org/articles/109...

Cool neurogenesis meeting in the Swiss Alps!!

'Neurogenesis from development to adulthood in health and disease'

To submit an application: asconameeting@unige.ch

Science brings us new miracles every day. Update from a mother whose son was the first patient dosed with Grace Science's gene therapy for NGly1 deficiency (GS-100). Video can be seen on YouTube. #glycotime

www.youtube.com/watch?v=tdNn...

Congratulations Catherine!! Super well deserved!! 🥂🎉

Protein tug-of-war controls pace of synaptic development, sets human brains apart Human-specific duplicates of SRGAP2 prolong cortical development by manipulating SYNGAP, an autism-linked protein that slows synaptic growth.

Nice cover of our work linking SRGAP2/SYNGAP1 synaptic neoteny and ID/ASD with @blibep.bsky.social @benvermaercke.bsky.social @franckp.bsky.social @boninlab.bsky.social @cecilecharrier.bsky.social www.thetransmitter.org/spectrum/pro...

Thank you Alzforum for featuring our new preprint identifying regulators of disease states of #microglia.

Project led by Amanda McQuade, computation by Reet Mishra, collaboration with the Nunez and De Jager labs.

Alzforum
www.alzforum.org/news/researc...

Preprint
www.biorxiv.org/content/10.1...

For obvious reasons, I've become fascinated with retrotransposons. So we ( @alexwhiteley.bsky.social and I) wrote an article now out in Neuron @cellpress.bsky.social on how we think retrotransposons influence brain function and health! kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...

During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost!

apply.interfolio.com/174756

Poster with QR code linking to the position

I'm very excited to announce that UNC Biology has 6 faculty positions open this year! The first is for an Asst Professor who studies organismal resilience using an integrative approach 1/n
unc.peopleadmin.com/postings/307...

✨ It's happening again! 🚀 Registration for Stem Cells in Neuroscience 2026 has officially opened! 🧠 Don't miss your chance to attend this exciting event with great keynote speakers, thought-provoking workshops and ample networking opportunities 👉🏼 www.stemcelltuebingen.com #neuroscience #stemcells

It should be great!

Interesting in aging, immune function, and organ health?

Join us for a super exciting joint Keystone Symposia in Banff, Canada in March 2026!!

@ericverdin.bsky.social

🎉 Congratulations to Needhi Bhalla, UC Santa Cruz (www.bhallalab.com
), named a 2025 #ASCB Fellow! This honor celebrates her outstanding contributions to cell biology, leadership, & service. Fellows will be recognized at #CellBio2025 in Philadelphia this December. #CellBiology

bioRxiv - An unbiased survey of distal element-gene regulatory interactions with direct-capture targeted Perturb-seq

New preprint from our lab!

What can we learn about the properties of gene regulatory elements by CRISPR’ing a random set of accessible sites in human cells?

Find out here: www.biorxiv.org/content/10.1...

👇

1/

Exciting meeting in beautiful Ascona, Switzerland!!

The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation - Nature Aging Aging is a risk factor for neurodegenerative diseases associated with protein aggregation. Here the authors identify age-related hyperactivation of EPS8/RAC signaling in C. elegans as a driver of path...

🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS.
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
🧵
www.nature.com/articles/s43...

Save the date and apply! We are organising another edition of the Monte Verità meeting “Neurogenesis from development to adulthood in health and disease”, March 30th to April 2nd 2026. Fantastic line up of speakers and beautiful setting! More details can be found here: neuro-unige.ch/news/csf-mee...

CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes - Nature Neuroscience The authors developed an adeno-associated virus-based high-throughput in vivo CRISPR screening platform for endogenous mouse brain cell types. Using this platform, they define genes and pathways essen...

Excited that the paper presenting our mouse brain in vivo CRISPR screening platform is out today in @natneuro.nature.com!

Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab.

www.nature.com/articles/s41...

Assistant Professor - Molecular, Cellular, and Developmental Neuroscience - Department of Neuroscience University of California, Berkeley is hiring. Apply now!

Come join our new Department of Neuroscience @ucberkeleyofficial.bsky.social as an Assistant Professor! aprecruit.berkeley.edu/JPF05041

Group Leader - Genome Biology Unit Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...

To all post-docs: The Genome Biology dept ‪@embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

The Anne West lab at Duke is hiring a postdoc to work on nuclear cell biology in neurogenesis. Please help me spread the word! Applications to west@neuro.duke.edu.

electron microscopy image of a C elegans on a yellow background

🧬June's most-read Genetics paper independently validates previous research showing that #CElegans can inherit learned pathogen avoidance: buff.ly/IFNoPF3

Have a paper people should see? See what our Editors look for: buff.ly/WiP1juL

Hallmarks of stem cell aging Aging disrupts core functions of somatic stem cells throughout the body, leading to impaired tissue maintenance and repair. We identify five key features of aged stem cells, highlighting how their dys...

Happy to share our review at Cell Stem Cell as part of their Hallmarks series. As always, a pleasure to work with friends and colleagues Anne Brunet (@brunetlab.bsky.social) and Peggy Goodell(@goodell-lab.bsky.social).

Hallmarks of stem cell aging: Cell Stem Cell www.cell.com/cell-stem-ce...

Hallmarks of stem cell aging As organisms age, somatic stem cells progressively lose their ability to sustain tissue homeostasis and support regeneration. Although stem cells are …

Excited to share our review on Hallmark of Stem Cell Aging! With Tom Rando and Peggy Goodell @goodell-lab.bsky.social!!

www.sciencedirect.com/science/arti...

Sleep need–dependent plasticity of a thalamic circuit promotes homeostatic recovery sleep Prolonged wakefulness leads to persistent, deep recovery sleep (RS). However, the neuronal circuits that mediate this process remain elusive. From a circuit screen in mice, we identified a group of th...

New collaborative study out with Mark Wu’s group identifies a thalamic reuniens-zona incerta circuit as both responsive to induced sleep deprivation and essential for mediating recovery sleep. Further perspective on this work follows./1
www.science.org/doi/epdf/10....