BrunetLab

✨ It's happening again! 🚀 Registration for Stem Cells in Neuroscience 2026 has officially opened! 🧠 Don't miss your chance to attend this exciting event with great keynote speakers, thought-provoking workshops and ample networking opportunities 👉🏼 www.stemcelltuebingen.com #neuroscience #stemcells

It should be great!

Interesting in aging, immune function, and organ health?

Join us for a super exciting joint Keystone Symposia in Banff, Canada in March 2026!!

@ericverdin.bsky.social

🎉 Congratulations to Needhi Bhalla, UC Santa Cruz (www.bhallalab.com
), named a 2025 #ASCB Fellow! This honor celebrates her outstanding contributions to cell biology, leadership, & service. Fellows will be recognized at #CellBio2025 in Philadelphia this December. #CellBiology

bioRxiv - An unbiased survey of distal element-gene regulatory interactions with direct-capture targeted Perturb-seq

New preprint from our lab!

What can we learn about the properties of gene regulatory elements by CRISPR’ing a random set of accessible sites in human cells?

Find out here: www.biorxiv.org/content/10.1...

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Exciting meeting in beautiful Ascona, Switzerland!!

The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation - Nature Aging Aging is a risk factor for neurodegenerative diseases associated with protein aggregation. Here the authors identify age-related hyperactivation of EPS8/RAC signaling in C. elegans as a driver of path...

🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS.
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
🧵
www.nature.com/articles/s43...

Save the date and apply! We are organising another edition of the Monte Verità meeting “Neurogenesis from development to adulthood in health and disease”, March 30th to April 2nd 2026. Fantastic line up of speakers and beautiful setting! More details can be found here: neuro-unige.ch/news/csf-mee...

CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes - Nature Neuroscience The authors developed an adeno-associated virus-based high-throughput in vivo CRISPR screening platform for endogenous mouse brain cell types. Using this platform, they define genes and pathways essen...

Excited that the paper presenting our mouse brain in vivo CRISPR screening platform is out today in @natneuro.nature.com!

Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab.

www.nature.com/articles/s41...

Assistant Professor - Molecular, Cellular, and Developmental Neuroscience - Department of Neuroscience University of California, Berkeley is hiring. Apply now!

Come join our new Department of Neuroscience @ucberkeleyofficial.bsky.social as an Assistant Professor! aprecruit.berkeley.edu/JPF05041

Group Leader - Genome Biology Unit Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...

To all post-docs: The Genome Biology dept ‪@embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

The Anne West lab at Duke is hiring a postdoc to work on nuclear cell biology in neurogenesis. Please help me spread the word! Applications to west@neuro.duke.edu.

electron microscopy image of a C elegans on a yellow background

🧬June's most-read Genetics paper independently validates previous research showing that #CElegans can inherit learned pathogen avoidance: buff.ly/IFNoPF3

Have a paper people should see? See what our Editors look for: buff.ly/WiP1juL

Hallmarks of stem cell aging Aging disrupts core functions of somatic stem cells throughout the body, leading to impaired tissue maintenance and repair. We identify five key features of aged stem cells, highlighting how their dys...

Happy to share our review at Cell Stem Cell as part of their Hallmarks series. As always, a pleasure to work with friends and colleagues Anne Brunet (@brunetlab.bsky.social) and Peggy Goodell(@goodell-lab.bsky.social).

Hallmarks of stem cell aging: Cell Stem Cell www.cell.com/cell-stem-ce...

Hallmarks of stem cell aging As organisms age, somatic stem cells progressively lose their ability to sustain tissue homeostasis and support regeneration. Although stem cells are …

Excited to share our review on Hallmark of Stem Cell Aging! With Tom Rando and Peggy Goodell @goodell-lab.bsky.social!!

www.sciencedirect.com/science/arti...

Sleep need–dependent plasticity of a thalamic circuit promotes homeostatic recovery sleep Prolonged wakefulness leads to persistent, deep recovery sleep (RS). However, the neuronal circuits that mediate this process remain elusive. From a circuit screen in mice, we identified a group of th...

New collaborative study out with Mark Wu’s group identifies a thalamic reuniens-zona incerta circuit as both responsive to induced sleep deprivation and essential for mediating recovery sleep. Further perspective on this work follows./1
www.science.org/doi/epdf/10....

Nobel laureate on how Trump's cuts are hurting science Neuroscientist, biologist and 2021 Nobel Prize winner Ardem Patapoutian joined Midday Edition to talk about how the Trump administration's effort to cut back on science spending is impacting researche...

I spoke with Jade Hindmon, host of @kpbssandiego.bsky.social Midday Edition, about the consequences of the current administration’s cuts to science funding. Please share to help spread the word and raise awareness.
www.kpbs.org/podcasts/kpb...

1/n Fellow C elegans enthusiasts!

For those of you using WormCat for RNA seq pathway analysis, we are working on the 3.0 version. Comments on annotations/website welcome. Either PM here or let's talk at the Worm meeting in Davis. #Worm25 #celegans

Highlighting this new paper NOT by my lab, but by Andres Vidal-Gadea's lab: doi.org/10.7554/eLif...
#Celegans - more to say on this later 🧪

Atul Butte died yesterday.
The world lost a giant.
A big bear of a man.
With a huge smile.
With love for everyone.
With energy that could power a room.
I loved everything about Atul.
I loved how he was always happy.
I loved how excited he was about science and helping people.

THOMAS BLACKWELL Obituary (1957 - 2025-05-09) - Boston, MA - Boston Globe View THOMAS KEITH BLACKWELL's obituary, send flowers and sign the guestbook.

Sad to learn we lost Keith Blackwell, an unsung hero of the aging field. Keith showed rapamycin extends C. elegans lifespan, that mTORC2 has diet-dependent effects on aging, and linked together skn1 TOR splicing and aging.
www.legacy.com/us/obituarie...

Resilience and restoration from fasting-refeeding mediated by a nutrient-regulated linker histone Intermittent fasting and fasting-refeeding regimens can slow biological aging across taxa[1][1]. Shifts between fed and fasted states activate ancient nutrient-sensing pathways which alter cellular an...

Preprint alert @biorxivpreprint! We are excited to share our latest study led by @kkawamura13.bsky.social @annadiederich01.bsky.social in collaboration with & C. Demetriades Lab & @muellerrom.bsky.social Lab
www.biorxiv.org/content/10.1...

I'm giving a talk tomorrow morning about my book ("How We Age"). But the slides already feel out of date because 1) there are so many new stories in the field, and 2) science as we know it is being destroyed, so the pipeline from ideas to drugs will dry up soon. Sigh

A few days late, but I’m happy to post our recent publication on body-to-brain signaling regulation of memory in Nature Aging:

KODAMA goes spatial.
doi.org/10.1101/2025...
#spatialtranscriptomics #visium #visiumhd #seurat #giotto

Body-to-brain insulin and Notch signaling regulates memory through neuronal CREB activity - Nature Aging Zhou, Novak and colleagues identify that the Caenorhabditis elegans hypodermis, a peripheral liver-like metabolic tissue, regulates memory via insulin/IGF-1 and Notch signaling, and show that activati...

Online now!✨RESEARCH: Zhou, Novak et al show that the hypodermis regulates memory in C. elegans via insulin/IGF-1 and Notch signaling; activating this pathway rescues CREB-dependent memory in aged worms @ctmurphy1.bsky.social www.nature.com/articles/s43... rdcu.be/eo3Pd

I'm excited to announce that I'll be starting a lab at UCSF in the @ihgatucsf.bsky.social and @ucsf-epibiostat.bsky.social in July.

We'll work at the intersection of statistical genetics, population genetics, and machine learning.

I have an opportunity to hire a staff scientist for my lab. Looking for someone with outstanding skillset in ML/statistics, genomics applications; interest in mentoring, strong publication record, PD experience required.

Email CV to me+cc my assistant (see 'contact' on my website). Ad to follow.

YouTube video by CSHL Leading Strand Interview with Coleen Murphy

Memory loss in aging - what are the mechanisms and can they be reversed? A fascinating conversation with @ctmurphy1.bsky.social youtu.be/To5KFveFm9c?...

Congratulations to our Human Neural Circuitry team; bit.ly/4dEyX7Z publishes today in Science! This was the hardest challenge of my career, but one of the most rewarding, after years of rebuilding– & expanding my inpatient neuropsychiatry in the service of basic discovery bsky.app/profile/deis...