Michael Kearse

Anyone at Harvard need a super well-trained undergrad next semester? Cell culture, molecular bio, microscopy and data analysis. Very careful and rigorous. Good lab citizen. Ready to jump in and learn/get some data! Has light course load, so plenty of time for research! Let me know of any leads!

📢 We are pleased to announce the Molecular Mechanisms of RNA in Disease – The NCCR RNA & Disease Final Symposium Jan 26-29, 2026, in St. Moritz!
🔗 Details & updates: finalsymposium.nccr-rna-and-disease.ch
@snf-fns-ch.bsky.social @unibe.ch @ethzurich.bsky.social

#RNAsky #RNAbiology

From @kylecottrell.bsky.social lab

rnajournal.cshlp.org/content/31/1...

Registration is open for "The complex life of #RNA" 2026 @embl.org in Heidelberg!

Excellent invited speakers and 30 short talks and even more flash talks selected from the abstracts!

Thank you to our sponsors for the GA RNA Salon @rnasociety.bsky.social and Lexogen- we hosted Dr. Francesca Storici for our annual symposium yesterday @dunhamlab.bsky.social @ghaleilab.bsky.social

Dang, hard disagree. The best papers to write and read are works of art, not merely a list of data and statements.

Don’t let LLMs take this away too, for gods sake.

Conservation and evolution of the programmed ribosomal frameshift in prfB across the bacterial domain | mBio Translation termination is catalyzed by one of two release factors in bacteria, RF1 or RF2. It has been known for decades that RF2 levels in Escherichia coli are regulated by a programmed ribosomal frameshift within the prfB gene that encodes RF2. We ...

Latest from the lab! Analysis of everyone’s favorite regulatory mechanism in bacteria — the RF2 programmed frameshift! Likely present in the ancestor of bacteria, use of this mechanism is influenced by stop codon usage! Big congrats to @cassidyprints.bsky.social
journals.asm.org/doi/10.1128/...

Thank you, Eugene! Julia has worked so hard on this project.

#RNAsky #RNAbiology

An autism spectrum disorder mutation in Topoisomerase 3β causes accumulation of covalent mRNA intermediates by disrupting metal binding within the zinc finger domain Abstract. The loss and mutation of Topoisomerase 3β (TOP3B), the only known eukaryotic topoisomerase with the ability to catalyze RNA strand passage reacti

Very proud of our recently published work in @narjournal.bsky.social led by senior PhD candidate Julia Warrick. #RNA

academic.oup.com/nar/article/...

What is in the Glenclairn!?

Tonight I celebrated the week with a Manhattan. My favorite recipe lately has been:
4 oz. whiskey (tonight was Barrell Bourbon batch 36)
1 oz. of Carpano Antica Formula Sweet Vermouth (no subs)
4 dashes of Angostura
2 dashes of plum bitters
2 dashes of peach bitters

Great lab, great mentor and I love UNC Biology!

The Johri Lab has an open postdoc position. Please send me an email, if interested. Start date is flexible. Please do share! Thank you in advance.

Cryo-EM structure of the naked mole-rat ribosome reveals a stabilized split 28S rRNA The naked mole-rat (Heterocephalus glaber) is a long-lived mammal with remarkable resistance to cancer and hypoxia, suggesting the evolution of robust proteostasis networks. The ribosome, the central ...

We have a new preprint for you. Naked mole rats are very long-lived rodents and have increased translational fidelity.

Interestingly, 28S ribosomal RNA is split. Here we investigated the structure of the ribosome by single particle cryo-EM. Take a look.
www.biorxiv.org/content/10.1...

Want to do a PhD in biology? Our projects for 2026 are now live! If you're considering a PhD, or know someone who is, we have projects that span the biosciences to serve as inspiration.

Reach out to our academics to discuss these or more options if you have an idea of your own 👇
bit.ly/dphilbio25

From MBoC: Timothy J. Stasevich, Colorado State University, developed All Probes Plasmids (APPs) to simplify single-mRNA translation imaging—just 2 plasmids for multicolor, long-term tracking. www.molbiolcell.org/doi/10.1091/... #CellBiology

mRNA poly(A)-tail length is a battleground for coronavirus–host competition Most eukaryotic mRNAs contain a poly(A) tail, which in post-embryonic cells enhances their stability. Many cytoplasmic RNA viruses also harbor poly(A) tails on their genomic RNA and mRNAs. Here, we re...

Check out the latest work from our lab, led by Arash Latifkar @ara-latifkar.bsky.social , www.biorxiv.org/content/10.1...

A Unifying Mechanism for Shared Splicing Aberrations in Splicing Factor Mutant Cancers Cancer-associated splicing factor (SF) mutations in SF3B1, U2AF1, and SRSF2 induce distinct changes in alternative splicing (AS). Yet these mutations are strikingly mutually exclusive, pointing to a c...

www.biorxiv.org/content/10.1...

Early career group leaders We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.

The @crick.ac.uk is recruiting Early Career Group Leaders

- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology

Deadline 27 Nov

www.crick.ac.uk/careers-stud...

Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.

Staff Scientist About EMBL-EBI EMBL’s European Bioinformatics Institute is a data powerhouse, utilised on a global scale to advance scientific discovery through bioinformatics and solutions to some of the world’s mos...

I am hiring! - looking for a Staff Scientist to co-run my research group with me. Staff Scientist is a senior professional scientist role at EMBL. Please forward to people you might know who could be interested! embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Much needed good news!! Our paper is just out in @jcb.org. We found a crazy antagonistic motor function that explains the elongation/retraction phenotype we see during LRRK2-dependent lysosomal tubulation. I am especially proud of Tsion, Nuria, Mia and Irene's contribution. Check it out!

Job alert ‼️ UChicago Micro is hiring! Open to tenured/tenure track faculty at all levels in any area of microbiology. Come join our amazing and growing department. apply.interfolio.com/174404

🚀 Our new paper is out @natmethods.nature.com!

Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.

🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/

🎉 Congratulations to Needhi Bhalla, UC Santa Cruz (www.bhallalab.com
), named a 2025 #ASCB Fellow! This honor celebrates her outstanding contributions to cell biology, leadership, & service. Fellows will be recognized at #CellBio2025 in Philadelphia this December. #CellBiology

@joachimgoedhart.bsky.social and Flurescent protein colleagues--help! With advice from imaging freinds, we tagged a protein of interest with "tagRFP", which we now know from its protein sequence and digging is a derivative of
eqFP578 from Entacmaea quadricolor. We want an antibody to it but 1/n

This preprint was accepted @rnajournal.bsky.social! It is now online ahead of print! @cancer-inst-purdue.bsky.social @purduernaclub.bsky.social rnajournal.cshlp.org/content/earl...

I’m excited to share that I’ve started a new chapter as Assistant Professor & Clinical Microbiology Section Director at @dukemedschool.bsky.social 🏥🔬.

This is a dream opportunity, and I’m so grateful 🙏. Looking forward to growing, learning, and advancing clinical microbiology & patient care 🚀💙.