Leander Goldbach

Uni Bern: Assistant Professor with tenure-track for Quantitative Cell Biology Start date of employment: anticipated for August 2027

Please spread the word! 10 days left to apply for this #sciencejobs as Assistant Professor Tenure Track in Quantitative Cell Biology 👩‍🔬
@izb-unibern.bsky.social @unibe.ch! ohws.prospective.ch/public/v1/jo...
#QueerInSTEM #DisabledInSTEM #BlackInSTEM #WomenInSTEM #CarersInSTEM #AcademicSky #HigherED

I'm curious if other mid career PIs have considered completely abandoning the trad publication model. We've been making gradual moves towards that end goal. But it's been difficult to completely jump ship for one main reason for me at least. 1/

How to be a scientist in a post-journal world When we created this site to write about things in science that need to be fixed, we chose not to start with publishing, even though it has been our preoccupation for decades.

As a junior researcher who is at the doorstep of the journal publishing system this post resonates with me a lot. Journal publishing looks like a historical contingency that's kept alive by the career promises that Nature publications make.
thescientistpapers.substack.com/p/how-to-be-...

Escherichia coli selection strains for growth-coupled metabolic engineering Synthetic metabolism has the potential to transform carbon capture, bioremediation, or bioproduction strategies. To transfer metabolic designs from an…

#Growth-coupled #selection just got an update ! In the last years, E. coli selection strains for #central , #amino #acid and #energy metabolism intermediates were created by the community. So, we compiled them and revisit the core concepts of growth coupling.

www.sciencedirect.com/science/arti...

Hey y'all, grant-pending, I may be unemployed starting from October. If you have any leads on biotech / postdoc positions in the German-speaking part of Switzerland, I'd greatly appreciate a message. I'm great with Data Analysis, Molecular Biology, and Teaching. (Plz RT!)

More at timothyfuqua.com

Rachel Thomas, PhD - Deep learning gets the glory, deep fact checking gets ignored an AI researcher going back to school for immunology

"a fascinating case study on the limits of AI in biology and the harms of current publishing incentives" rachel.fast.ai/posts/2025-0...

EvoSur MOTIVACIÓN

🔊 ¡Llamado a pensar la evolución desde el sur!
Invitamos a estudiantes de maestría y doctorado en biología evolutiva de Sudamérica a postularse a EvoSur.
🧬 Un espacio para intercambiar ideas, debatir evolución y tejer redes científicas con todas las voces, todas:
sites.google.com/view/evosur2...

How can physics contribute to understanding the evolution of complexity? Although great results have been produced over the last decades, some recent "theories" appear to ignore key ideas from evolutionary theory and are seriously flawed. Check this paper in PNAS www.pnas.org/doi/abs/10.1...

Here is a cool Flow-Lenia simulation, which is a continuous cellular automaton with two distinct features:
1. Mass conservation - sum of all activations is constant through time
2. Localized update rules - enables simulations with differently behaving matter on the same grid

The emergence of eukaryotes as an evolutionary algorithmic phase transition | PNAS The origin of eukaryotes represents one of the most significant events in evolution since it allowed the posterior emergence of multicellular organ...

Was protein size the constraint that made splicing and thus nuclei necessary for biological novelty 2.3-2.6My ago? Elegant paper with exciting implications.
www.pnas.org/doi/abs/10.1...

Is this an active form of protest against graphical abstracts?

Allobates zaparo knows it's a fraud.

The first version of this post had a broken link and I deleted it. Please spread again this corrected version. Thanks😊.

Inside me there are two wolves. One of them has a 15 genome edits the other 20 genome edits. Neither of them is a dire wolf.

yes sadly. We talk a lot about the evils of Impact Factors but scientists are to Nature as sneaker junkies are to Nike.

From Organisms to Superorganisms: Major Transitions in Biological Complexity - William Ratcliff, Georgia Tech The Surprisingly Simple Origins of Complex Life William Ratcliff, Georgia Tech   Life on Earth has repeatedly undergone dramatic increases in complexity via…

Here's a talk I gave at the Kavli Fontiers in Science symposium two weeks ago. It is pitched as a general introduction to evolutionary transitions in individuality.

It was a good one- this might be a good teaching resource for evo bio courses. It is clear and high-level.

vimeo.com/1066647126

Lungfish xkcd.com/3064

The simplicity of protein sequence-function relationships - Nature Communications Understanding protein sequence-function relationships is complicated by high order epistatic interactions among residues, although the extent of these interactions remains uncertain. Here, the authors...

nature.com/articles/s41467-024-51895-5, its reply
doi.org/10.1101/2024.01.29.577800,
and the reply to the reply
doi.org/10.1101/2024.09.17.613512
cleared up so much of the confusion I had about epistasis. Publishing such discussions and reviewer comments is invaluable. Appreciate both lab's efforts.

🤔 The 🇩🇰 government asked us: how can democratic control over tech giants be strengthened?

We - the government's expert group on tech giants - outline 7️⃣ principles and a set of guidelines for tackling economic, democratic, and security vulnerabilities:

One-carbon fixation via the synthetic reductive glycine pathway exceeds yield of the Calvin cycle - Nature Microbiology An engineered one-carbon-fixation pathway increases biomass yields of Cupriavidus necator compared with the Calvin cycle and can support future, sustainable bio-based production.

Super excited to see my main PhD project finally out in @naturemicrobiol.bsky.social www.nature.com/articles/s41.... We show for the first time that a synthetic and engineered pathway can indeed exceed nature at one-carbon fixation.

When you switch to Discussion-writing mode

Experimental evolution of evolvability Evolvability—the capacity to generate adaptive variation—is a trait that can itself evolve through natural selection. However, the idea that mutation can become biased toward adaptive outcomes remains...

Amazing effort and results. I have been wondering when someone would confirm experimentally what has been predicted by Kashtan, Noor & @urialonlab.bsky.social (www.pnas.org/doi/full/10....), and similar papers from that time.

Experimental evolution of evolvability www.science.org/doi/10.1126/...

I feel like Catalytic Computing could be an interesting analogy to biological development where the line between algorithmic regions and memory regions in the genome is also very blurry. Maybe this blur has benefits beyond resource optimization.

Nearly $14 million of Northeastern research grants deemed ‘neo-Marxist propaganda’ in investigation led by Ted Cruz - The Huntington News Sen. Ted Cruz released a database of over 3,400 National Science Foundation grants awarded towards what he deemed “questionable” research. Nineteen of the listed grants were Northeastern research proj...

Mitochondria and its division of labor w/ Nucleus is apparently very Neo-marxist... 😅

Title of NSF grant cut: "Role of Mitochondria as Intracellular Shuttles for Nuclear Gene-Regulatory Transcription Factors During Pluripotent Cell Division and Fate Specification"

huntnewsnu.com/83890/campus...

Me @plosbiology.org
🤝
struggling with .eps

Getting stuck in the Adobe account verification popup of a Photoshop installation I didn't know I had just because the supplementary figure was in .eps format.