Andrew Octavian Sasmita

Axonal tau reduction ameliorates tau and amyloid pathology in a mouse model of Alzheimer’s disease - Translational Neurodegeneration Background Pathological deposition of hyperphosphorylated tau in the brain closely correlates with the course of Alzheimer’s disease (AD). Tau pathology occurs in axons of affected neurons and tau rem...

Axonal tau reduction ameliorates tau and amyloid pathology in a mouse model of Alzheimer’s disease

translationalneurodegeneration.biomedcentral.com/articles/10....

Role of oligodendroglial ADAM10 in oligodendrocyte maturation, myelination and myelin maintenance https://www.biorxiv.org/content/10.1101/2025.07.25.666787v1

Astrocytes (🔵) and microglia (🟡) in the hippocampus of a mouse brain for #FluorescenceFriday

We had fun assembling images and describing approaches for imaging oligodendrocytes and myelin in vivo, in organotypic slices, and in fixed tissues. This work started in the lab of @jgrutzendler.bsky.social over 10 years ago and continues to keep us busy.
www.nature.com/articles/s44...

Shared and disease-specific pathways in frontotemporal dementia and Alzheimer’s and Parkinson’s diseases - Nature Medicine Large-scale plasma proteomics of 10,527 samples from the Global Neurodegeneration Proteomics Consortium identified shared and disease-specific pathways in Alzheimer’s disease, Parkinson’s disease and ...

Shared and disease-specific pathways in frontotemporal dementia and Alzheimer’s and Parkinson’s diseases www.nature.com/articles/s41...

Triglyceride metabolism controls inflammation and microglial phenotypes associated with APOE4 Neuroinflammation is central to Alzheimer’s disease pathogenesis. Stephenson et al. establish that neutral lipid accumulation is necessary for microglial activation and that microglia expressing an Alzheimer’s risk gene hijack triglyceride biosynthesis to acquire a basal immune activated state. Targeting triglyceride metabolism can modulate immune reactivity and disease phenotypes.

Triglyceride metabolism controls inflammation and microglial phenotypes associated with APOE4

Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease - Nature Neuroscience The dynamics of microglia states adjacent to or far from amyloid-beta plaques are unclear. Here the authors show that non-plaque-associated microglia modulate the cell population expansion in response...

Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease | Nature Neuroscience

www.nature.com/articles/s41...

Mitochondrial origins of the pressure to sleep - Nature Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.

Mitochondrial origins of the pressure to sleep

Microbiota-driven antitumour immunity mediated by dendritic cell migration - Nature A newly identified bacterial strain (YB328) isolated from the faeces of patients who responded to immune checkpoint blockade therapies can promote antitumour immunity through the activation of tumour-...

Microbiota-driven antitumour immunity mediated by dendritic cell migration

www.nature.com/articles/s41...

Behavioral assessment and gene expression changes in a mouse model with dysfunctional STAT1 signaling - Cell Communication and Signaling Background Signal transduction via the Signal Transducer and Activator of Transcription 1 (STAT1) pathway is indispensable for mediating the intracellular effects of interferon-α (IFN-α), interferon-γ...

Behavioral assessment and gene expression changes in a mouse model with dysfunctional STAT1 signaling

biosignaling.biomedcentral.com/articles/10....

Why We Still Need Animal Research in a World of AI and Organoids The portrayal of uncaring scientists without any thought for the animals being used in their research is far from the truth.

While I’m a big fan of new technologies that help us study human biology…there’s still no replacement for animal research! See my article in Gen News. www.genengnews.com/topics/trans...

Differences of the 6N and 6J Substrains of C57BL/6 Mice in the Development of Experimental Autoimmune Encephalomyelitis The 6J substrain exhibits more severe EAE than 6N, with increased macrophages, CD8+, and B cells in the CNS, as well as a higher proinflammatory profile and lower anti-inflammatory profile, correlati...

Differences of the 6N and 6J Substrains of C57BL/6 Mice in the Development of Experimental Autoimmune Encephalomyelitis

onlinelibrary.wiley.com/doi/10.1002/...

#GLIA2025 is right around the corner! Catch the poster presentations from Klaus-Armin Nave’s group and talk all things glia in health and in Alzheimer’s disease ✌🏼

@gliameeting.bsky.social

Amyloid-Beta Pathology and Cognitive Performance in Centenarians This study explores whether amyloid beta pathology in centenarians is associated with cognitive performance.

Amyloid-Beta Pathology and Cognitive Performance in Centenarians

jamanetwork.com/journals/jam...

Emerging connections between myelin and Alzheimer’s disease - Nature Cell Biology Recent literature has explored the contributions of oligodendrocytes and myelin dysfunction to Alzheimer’s disease. Here, we discuss emerging evidence that oligodendrocytes may directly contribute to ...

Emerging connections between myelin and Alzheimer’s disease

www.nature.com/articles/s41...

Mutations in the human CSF1R gene impact microglia’s maintenance of brain white matter integrity - Nature Immunology Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia is a neurodegenerative disorder caused by pathogenic CSF1R mutations. Here the authors find that microglial loss is linked to r...

Mutations in the human CSF1R gene impact microglia’s maintenance of brain white matter integrity
www.nature.com/articles/s41...

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a cau…

🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...

Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammation - Nature Dysregulated CD4 T cells that recognize gut commensal antigens are able to infiltrate the central nervous systems and are re-stimulated by host proteins, resulting in neuroinflammation.

Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammation @nature.com
www.nature.com/articles/s41...

Another fly muscle imaging day.
#Drosophila #flymuscle #microscope #bioimaging

Amyloid precursor protein carboxy-terminal fragments as catalyzers of endolysosomal dysfunction in Alzheimer’s disease Proteolytic processing of the amyloid precursor protein (APP) generates not only the well-known β-amyloid (Aβ) peptides but also APP C-terminal fragments (APP-CTFs). Recent evidence from studies in mu...

Amyloid precursor protein carboxy-terminal fragments as catalyzers of endolysosomal dysfunction in Alzheimer’s disease

www.cell.com/trends/neuro...

Gorgeous (as always)!!

Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain - Nature Neuroscience In Alzheimer’s disease (AD), disruptions in myelin and axonal structures occur, although the underlying mechanisms remain unclear. Here the authors show that, at the myelin–axon interface, axon–glial ...

Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain

www.nature.com/articles/s41...

A role for microglia in mediating the microbiota–gut–brain axis - Nature Reviews Immunology This Perspective explores how the gut microbiota influences the function and heterogeneity of microglia, highlighting their roles in neurological and neuropsychiatric disorders, and discusses the ther...

Thrilled to see our review out in @natrevimmunol.nature.com together with my amazing mentors @jfcryan.bsky.social and Ger Clarke. @apcmicrobiomeirel.bsky.social @anatneuroucc.bsky.social @uccresearch.bsky.social

www.nature.com/articles/s41...

Excited to share our new paper out in @cp-neuron.bsky.social today! We discovered the neuroanatomical route that myeloid cells use to enter the brain parenchyma. Check it out here: authors.elsevier.com/c/1lCYs3BtfH...

The glia‐immune network: Astrocytes and oligodendrocytes as microglial co‐ordinators in health and disease Abstract figure legend The glia-immune network involves the communication(s) of glia via immune signalling pathways. In neuro-homeostasis these pathways have been shown to modulate key processes such...

New topical review from Verity Mitchener,
Mille Thackray and Lorena Arancibia-Cárcamo of
@ukdri.ac.uk on the glia-immune network in health and disease, with a focus on how astrocytes and oligodendrocytes coordinate microglia in Alzheimer's disease pathology

Exploring Iron Deposition Patterns Using Light and Electron Microscopy in the Mouse Brain Across Aging and Alzheimer's Disease Pathology Conditions (Figure created with Biorender.com. Publication license has been obtained with Biorender).

Exploring Iron Deposition Patterns Using Light and Electron Microscopy in the Mouse Brain Across Aging and Alzheimer's Disease Pathology Conditions

onlinelibrary.wiley.com/doi/10.1111/...

Immunostaining of a mouse brain (hippocampus) section with GluT1 🟣 and ALDH1L1 🟢. Nuclei have been visualized by DAPI staining 🔵.

#bloodbrainbarrier
#FluorescenceFriday

Gorgeous 😍 which ALDH1L1 antibody is this, if I may ask?

Here is a direct link to the open access article ‪@amit-das.bsky.social‬ mentions. alz-journals.onlinelibrary.wiley.com/doi/10.1002/... Tempting to say it feels like a miracle, but this progress always comes down to dedicated study participants, brilliant scientists, and reliably funded science.