Andrew Octavian Sasmita

In the desert of tools to manipulate oligodendrocytes in the brain, we built an OASIS. 🌿 Pun intended. I’m still in awe every time I spot an amazing-looking cell. The beauty of OL and myelin never fails me!
Hope this tool helps more people see it too.

Myelin injury precedes axonal injury and symptomatic onset in multiple sclerosis - Nature Medicine Myelin damage in multiple sclerosis can be detected up to 7 years before symptoms, with early immune pathway activation and a 21-protein panel showing promise for presymptomatic diagnosis.

Myelin injury precedes axonal injury and symptomatic onset in multiple sclerosis www.nature.com/articles/s41...

Microbial metabolite indole-3-propionic acid drives mitochondrial respiration in CD4+ T cells to confer protection against intestinal inflammation - Nature Metabolism The gut microbiota-derived metabolite indole-3-propionic acid (IPA) is found to enhance mitochondrial fatty acid and amino acid oxidation in CD4+ T cells. In mice, IPA-mediated metabolic reprogramming...

Microbial metabolite indole-3-propionic acid drives mitochondrial respiration in CD4+ T cells to confer protection against intestinal inflammation

www.nature.com/articles/s42...

Apolipoprotein ε4 exacerbates white matter impairment in a mouse model of Aβ amyloidosis by decreasing actively myelinating oligodendrocytes INTRODUCTION The ε4 allele of the apolipoprotein E (APOE) gene is a risk factor for the development of Alzheimer's disease (AD). APOE4 isoform is associated with increased white matter lesions in hu...

Apolipoprotein ε4 exacerbates white matter impairment in a mouse model of Aβ amyloidosis by decreasing actively myelinating oligodendrocytes

alz-journals.onlinelibrary.wiley.com/doi/full/10....

Rainbow shading of a confocal micrograph of a developing mouse neural tube. The protein actin is stained and colored in rainbow to indicate depth in the section.

Happy #FluorescenceFriday! This is a maximum intensity projection of depth shaded actin (🌈) in a section from an E9.5 🐭 neural tube (NT). 🔬 by postdoc @christinaadaly.bsky.social 👩‍🔬 🧪 Image shows the floor plate and lumen of the developing NT.

#SciArt #DevBio #DevNeuro

Intercellular communication in the brain through a dendritic nanotubular network Intercellular nanotubular networks mediate material exchange, but their existence in neurons remains to be explored in detail. We identified long, thin dendritic filopodia forming direct dendrite–dend...

Dendritic nanotubes! What’s next?

www.science.org/doi/10.1126/...

Presented our work at the Glia Congress 2025 a few months ago on the topic of oligodendrocytes in Alzheimer’s disease and was awarded the stipend! Many thanks to the organizers and grateful for the wonderful discussions with old and new connections.

New landscape of the diagnosis of Alzheimer's disease Alzheimer's disease involves a drastic departure from the cognitive, functional, and behavioural trajectory of normal ageing, and is both a dreaded and highly prevalent cause of disability to individu...

New landscape of the diagnosis of Alzheimer's disease www.thelancet.com/journals/lan... by @thelancet.com

#Alzheimers #dementia #biomarkers #neuroscience #NeuroSkyence

Our new preprint is up! This is the main postdoc work of @wiesner-t.bsky.social focusing on exocytosis along the axon shaft and its regulation by the sub membrane actin-spectrin scaffold: www.biorxiv.org/content/10.1...
Read the thread below for a summary of our findings 🧵1/11

Alpha synuclein-mediated cytoskeletal dysfunction impairs myelination in human oligodendrocytes - Acta Neuropathologica Oligodendroglial alpha-synuclein (aSyn) deposits are a key feature in the atypical parkinsonian disorder, multiple system atrophy (MSA) linked to profound myelin loss and neurodegeneration while preci...

Alpha synuclein-mediated cytoskeletal dysfunction impairs myelination in human oligodendrocytes

link.springer.com/article/10.1...

Smoking affects gut immune system of patients with inflammatory bowel diseases by modulating metabolomic profiles and mucosal microbiota Background The aetiology and pathogenesis of IBD are intricate, involving genetic and environmental factors. Notably, cigarette smoking has contrasting effects, being detrimental to Crohn’s disease (C...

Smoking affects gut immune system of patients with inflammatory bowel diseases by modulating metabolomic profiles and mucosal microbiota

gut.bmj.com/content/earl...

Thrilled to share our new paper @cp-cell.bsky.social:
“Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.”

This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling.

🔗 www.cell.com/cell/fulltex...

Faust et al., Cell 2025

Maternal inheritance suppresses CAA and amyloid plaques in 5xFAD (Tg7031)/APOE4 mice In their recent study, Sasmita et al.1 reported that the parental origin of the 5xFAD (Tg6799) transgene substantially influences amyloid-β (Aβ) plaque deposition in this widely used amyloid model for...

Important validation of our reported transgenic inheritance effect in a distinct 5xFAD line from the lab of David Holtzman!

www.cell.com/neuron/abstr...

Cortical tau deposition promotes atrophy in connected white matter regions in Alzheimer’s disease In Alzheimer’s disease, tau pathology not only contributes to cortical atrophy but also leads to the degeneration of white matter tracts that connect diffe

Cortical tau deposition promotes atrophy in connected white matter regions in Alzheimer’s disease url: academic.oup.com/brain/articl...
#tao @nfranzme.bsky.social

Mitochondria delay action potential propagation - Communications Biology Modeling mitochondria-containing thin unmyelinated axons based on songbird premotor axon electron microscopy shows that mitochondria slow conduction velocity, delaying action potential propagation.

Mitochondria delay action potential propagation.

www.nature.com/articles/s42...

Human myelinated brain organoids with integrated microglia as a model for myelin repair and remyelinating therapies Human myelinated brain organoids with integrated microglia can be used to investigate demyelination, remyelination, and remyelinating therapies.

Human myelinated brain organoids with integrated microglia as a model for myelin repair and remyelinating therapies

www.science.org/doi/10.1126/...

Neurons sequester the cholesterol-inhibiting TFEB in oligodendrocyte cytoplasm to safeguard myelination and neural function Myelination is essential for normal brain function, yet the mechanisms governing neuron-oligodendrocyte interactions that ensure proper myelination le…

Neurons sequester the cholesterol-inhibiting TFEB in oligodendrocyte cytoplasm to safeguard myelination and neural function

www.sciencedirect.com/science/arti...

Adaptor protein complex 2 (AP2) participates in biogenesis and homeostasis of myelin sheaths in the central nervous system Myelination of CNS axons requires oligodendrocytes to undergo extensive morphological changes by producing large amounts of myelin membrane with defined protein composition and structure. The formatio...

If you're interested in trafficking of #myelin constituents in #oligodendrocytes, and of course you are, you may want to check out our new preprint. It's very nice PhD work by @sophiesiems.bsky.social, and we're grateful to all who contributed!

www.biorxiv.org/content/10.1...

Amyloid-β-driven Alzheimer’s disease reshapes the colonic immune system in mice Makhijani et al. investigate the colonic immune landscape in the 5XFAD model, showing a reduction in CXCR4+ antibody-secreting cells and a concomitant increase in brain CXCL12. Dietary intervention wi...

Amyloid-β-driven Alzheimer’s disease reshapes the colonic immune system in mice.

www.cell.com/cell-reports...

Imaging myelin degradation in ex vivo prefrontal cortex tissue blocks in Alzheimer's disease and chronic traumatic encephalopathy INTRODUCTION Alzheimer's disease (AD) and chronic traumatic encephalopathy (CTE) are tauopathies with gray matter (GM) myelin changes that are challenging to assess with standard imaging. New method...

Imaging myelin degradation in ex vivo prefrontal cortex tissue blocks in Alzheimer's disease and chronic traumatic encephalopathy

alz-journals.onlinelibrary.wiley.com/doi/full/10....

Axonal injury is a targetable driver of glioblastoma progression - Nature Axonal injury, induced in the white matter by expansion of early tumour cells, is a key driver of glioblastoma progression.

Nature research paper: Axonal injury is a targetable driver of glioblastoma progression

go.nature.com/4lFmpiN

Thrilled to share our new study showing microglia prune astrocyte processes in adult brain, to regulate synaptic transmission, hypothalamic neuron activity, and salt-induced hypertension in🐀. Huge team effort - congratulations to all🥂🍾🎉

Axonal Degeneration Across the Alzheimer's Disease Spectrum: A Longitudinal MRI and Fluid Biomarker Study https://www.medrxiv.org/content/10.1101/2025.08.13.25333630v1

Restoring amyloid-β42 and γ-secretase function in Alzheimer’s disease Espay et al. challenge the view that Alzheimer’s disease is caused by increased gamma-secretase activity and overproduction of Aβ42. Instead, they suggest

Restoring amyloid-β42 and γ-secretase function in Alzheimer’s disease

academic.oup.com/brain/advanc...

Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson’s disease - Nature Neuroscience Parkinson’s disease (PD) involves toxic protein buildup and energy failure in neurons. Continuously breathing low-oxygen air protected mice from PD-like neuronal loss and reversed symptoms, even after...

Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson’s disease

www.nature.com/articles/s41...

Glial cells & lipoproteins coordinate lipid & immune signaling to regulate CNS #inflammation. @vinitiwari1.bsky.social & Mikael Simons review the relationship btwn lipid #metabolism & inflammation & how disruptions in this interplay contribute to neurological disorders rupress.org/jem/article/...

The vascular contribution to cognitive decline in ageing and dementia - Nature Reviews Neuroscience Growing evidence suggests that reduced cerebral blood flow contributes to cognitive decline in ageing and dementia. Attwell and colleagues discuss the underlying mechanisms and functional consequences...

The vascular contribution to cognitive decline in ageing and dementia

www.nature.com/articles/s41...

Axonal tau reduction ameliorates tau and amyloid pathology in a mouse model of Alzheimer’s disease - Translational Neurodegeneration Background Pathological deposition of hyperphosphorylated tau in the brain closely correlates with the course of Alzheimer’s disease (AD). Tau pathology occurs in axons of affected neurons and tau rem...

Axonal tau reduction ameliorates tau and amyloid pathology in a mouse model of Alzheimer’s disease

translationalneurodegeneration.biomedcentral.com/articles/10....

Role of oligodendroglial ADAM10 in oligodendrocyte maturation, myelination and myelin maintenance https://www.biorxiv.org/content/10.1101/2025.07.25.666787v1

Astrocytes (🔵) and microglia (🟡) in the hippocampus of a mouse brain for #FluorescenceFriday