DMartin

A role for the autophagy receptor NBR1 in the degradation of tau aggregates Neurofibrillary tangles (NFTs), comprising hyperphosphorylated and aggregated Tau protein, are a primary neuropathological feature of Alzheimer's Dise…

Happy to share our latest, by my PhD student Marie... sad because it was her last day today, happy because it coincided with her paper being out! www.sciencedirect.com/science/arti...

Big thanks to Cure VCP Disease for believing in our research!

For more info check out:
www.upliftingathletes.org
www.curevcp.org

Incredibly excited to share we're in Philly tonight to fete @firyalrphd.bsky.social who was a 2026 Uplifting Athletes Draft pick supported by Cure VCP Disease Inc. These awards support early career researchers studying rare diseases. Firyal is working developing genetic therapies for VCP disease.

Was doing this bit a few weeks ago as I made @drssfs.bsky.social bday cake :-p

Honestly, I really love O'Hara. I was always excited to see her on the screen. I remember watching her in SCTV reruns after I'd seen her in Home alone (I'm the same age as Kevin so that was my 1st intro) & loved her. Then all the Christopher Guest films & Schitt's Creek. She was just awesome.

First paper/review of the year accepted! Can't wait to share with you all when it's out. All the credit goes to the very talented @cailyncreative.bsky.social

The world needs more Catharine O'Hara. Not less. This is a sad day.

CIHR Project Grants cratering again. Impact-.

And they'd still be large grants. The one thing Canadian researchers can do better than anyone is get way more out of way less. The sad thing is we kick ass working at bare bones. Imagine if we were unleashed by real funding!

Same. I love how NSERC works. During the pandemic, they responded the best of any funding agency. And their approach to fund more with less is better. They actually apply EDI. The preferential value just comes from the size of the grants. CIHR could double the grants by reducing budgets in half.

Haha. Thanks. I don't know anymore. The situation is bad for everyone. So, I try not to sweat it (just need to grieve every app tho). I know what we're doing is important (acknowledged by reviewers) & relevant. I'd like to do more, but without significant funds we just can't... I've accepted my lot

For sure. I wouldn't have gotten tenure at other unis I think. But I know lots of other researchers across Canada in similar situations that got tenure with NSERC + other funds. I don't think that would be enough at UBC or UofT. But that's also where all the CIHR grants go.... So....

For sure. I've submitted 10 grants to cihr. Never discussed. 9 were submitted as an ECR. For me, CIHR is not a real option, especially Bc where I am. NSERC is tho & non-profits & Brain Canada. I have to write 6-10+ grants a year to stay alive. It's all very piecemeal, but it's what works for now.

For all my complaining, many do. Well, at least if you have NSERC & other funding. There's definitely a bias at CIHR against many unis that is recognized & considered when you apply for tenure.

Ironically, it was during those funding rates that I got into research.

If there's any consolation I think there are many more options for funding now.

Unfortunately, they're not stable or for as long, but still...

So very depressing

Thanks. I think they're about what you'd expect. All the comments are easily addressable. They were all minor. They're focused on the over expression system we used, not the many systems we have to look at endogenous pathways in patient cells or mouse models moving forward.

Our grant wasn't discussed again, but now that I know how many were funded, etc. I can say the grant did much better even tho our score didn't change. Gonna take it as a win & try again.

That's awesome! Congrats!

If you were one of the researchers on the cusp of funding, I hope you hear good things from CIHR today.

Best gene synthesis company that does not involve sending $CAD from taxpayers' money south of the border? #synbio

Former Liberal cabinet minister Kirsty Duncan dies at 59 OTTAWA — Former Liberal cabinet minister Kirsty Duncan has died at the age of 59 following a years-long battle with cancer. Born on Oct.

Gutted to learn of the passing of Dr Kirsty Duncan.

She was a tireless fighter for the people she served, not only her local community in Toronto but others, especially the science & research &
athletics communities too.

She championed equity, diversity, inclusion and made change happen.

🤍🙏🏻

Former Liberal cabinet minister Kirsty Duncan dies at 59 | CBC News Former Liberal cabinet minister Kirsty Duncan has died at the age of 59 following a years-long battle with cancer.

Sad news. She was very much a solo voice in cabinet for science. Even agter she was bumped, she continued to be a voice for the scientific community. www.cbc.ca/news/canada/...

Sadly, this didn't age well....
Sadly, I wrote that last night....

Anyone else feel like this was a good week? Like the first in a while?

Can any labs in the GTA recommend a company to repair a cell culture incubator? Rayco wants to charge the cost of the incubator just to look at it.

I've definitely had some really good reviews. But I've had too many where it's clear they didn't read my grant. When only a handful get funded I kind of get it. Why bother doing a good job if you know it's not getting funded?

I think you'd scream if I sent you my comments...