Ryan Morin 🇨🇦

Wow! We should hang out more often!

A photograph of the late Lee "Scratch" Perry

Post your favourite Doctor Who. Wrong answers only

@dgermain21.bsky.social - fantastic work on LymphomaMAPs (microenv of DLBCL) looking at prognosis of CAR-T therapy. Showed that TEX archetype associated with signif worse outcome. Assoc with
• exhausted T-cells
• super-activated macrophages.
#ICML18

Figure showing number of deaths averted due to vaccines from 1974-2024

Vaccines have literally saved more than 150 million lives over the last 50 years and prevented much more morbidity but hold up guys somebody with a brain worm knows better

Excited to report our Blood Cancer Discovery
@theaacr.bsky.social article showing how DNA #methylation in #Burkitt #Lymphoma #BL impacts clinical outcome. Team effort co-led by @morinryan.bsky.social @sfu.ca group and our lab at @carrerasijc.bsky.social @ub.edu
aacrjournals.org/bloodcancerd...

The Human Genome Project cost taxpayers $3 Billion.

Two decades on, it has generated a staggering return on investment of $1 Trillion, with benefits in medicine, agriculture, energy, the environment, & more.

If you want to boost the economy, funding science is one of the best things you could do.

Lungfish xkcd.com/3064

Screenshot of sandbox.bio website

In 2024, sandbox.bio had >170,000 tutorial page views! 🥳

The most popular tutorials were:
1. ​Terminal basics
2. ​Genomic intervals with bedtools
3. ​Terminal exercises
4. ​Data exploration with awk
5. ​DNA sequencing QC

Check them out here: sandbox.bio/tutorials

Justin Trudeau gave the exact kind of press conference today that we have been waiting for from our Democratic leaders. Watch it and learn from it. No gimmicks, no stunts, no script, no platitudes, no slogans, no games. Just straight talk, honesty, sincerity and facts.

I’m somehow on a Heritage Foundation mailing list (😂) and they sent a survey to see what we think of DOGE.

Who wants to offer some m-fing feedback?!?

secured.heritage.org/the-heritage...

Please share with a friend or a thousand :)

Tomorrow is #RareDiseaseDay! Did you know that a disease is considered rare when it affects fewer than 1 in 2,000 people? But with 7,000+ rare diseases worldwide, they collectively affect 300M+ people.

Support the ASH Research Awards Fund 🔗 https://bit.ly/3XjCFNr

#hematology #HemeSky #BloodSky

Genome Interval Arithmetic Read and manipulate genome intervals and signals. Provides functionality similar to command-line tool suites within R, enabling interactive analysis and visualization of genome-scale data. Riemondy et...

"valr provides tools to read and manipulate genome intervals and signals, similar to the BEDtools suite."

I wonder if they considered naming it bedRtools?
rnabioco.github.io/valr/

Get in dorks, we're going protesting!

STAND UP FOR SCIENCE WITH US ON MARCH 7TH, 2025
WASHINGTON DC AND EVERY STATE CAPITOL

Because science is for everyone!

Find us at www.standupforscience2025.org

#standupforscience2025 #scienceforall #sciencenotsilence

If you are an NIH or CDC scientist that lost your job, we have a home for you at UTHealth. I’m hiring physician scientists and we also have transplant ID fellowship slots open. Contact me. #IDSky #MedSky

A word cloud in the shape of a Maple Leaf. Some of the largest words include multiculturalism rights liberal citizenship minority political multicultural justice theory animal review Canada nationalism politics social new diversity las liberalism will Canadian state identity welfare del federalism les national animals cultural

Happy #FlagDay from ScholarGoggler

scholargoggler.com

Him right now: “grok: is there a LLM that can modify ancient proprietary COBOL subroutines on a production mainframe for me?”

If the NLM page does go down (long-term) there will be no further updates to the contents of the EBI mirror, though, right?

*early career

Remember that Europe (@ebi.embl.org) has mirrored all these services and they will keep on running. They look and feel a bit different but do the same thing. I think @ewanbirney.bsky.social should be able to confirm.

www.europepmc.org
www.ebi.ac.uk/jdispatcher/...

Benchmarking 13 tools for mutational signature attribution, including a new and improved algorithm https://academic.oup.com/bib/article/26/1/bbaf042/8002975 🧬🖥️🧪 https://github.com/Rozen-Lab/sig_attribution_paper_code

Looks like a bunch of people are trying to make a back-up before it's too late!

beyond reckless!

"(staff) hoping to prevent as much damage as possible — [...] avoiding crashes or a system-wide breakdown caused by rapidly pushing new code into production with a limited knowledge of the system and its dependencies across the federal government"

Quantifying metabolites using structure-switching aptamers coupled to DNA sequencing Nature Biotechnology - Metabolites can be quantified using a combination of aptamers and DNA barcodes.

Delighted to share our latest paper describing a method to read the levels of hundreds of metabolites or drugs in parallel using DNA sequencing. This method, which we call ‘smol-seq’ (Small MOLecule sequencing), harnesses the power of DNA sequencing for metabolite detection:
rdcu.be/d8xLv (1/6)

Does anyone happen to have a backup of PubMed, just in case?
How about dbGaP? Genomic Data Commons? 😬

A cartoon is headed “How tariffs work”. It proceeds to show a cartoon of Trump in his suit and red tie taking a piss towards a fan with a Canadian maple leaf on it. The fan blows Trump’s piss back into his face. It was drawn and is signed by Bruce MacKinnon and is dated November 26, 2024

Bruce MacKinnon, the editorial cartoonist at the Halifax Chronicle-Herald, drew this last November.

No newspaper would print it.

It now deserves an outing.

The Google Scholar PDF Reader extension has always shown an outline, makes references clickable/linked to GScholar (screenshot 1). Now it provides an AI summary of each section (screenshot 2). https://chromewebstore.google.com/detail/google-scholar-pdf-reader/dahenjhkoodjbpjheillcadbppiidmhp?hl=en

Synchronized long-read genome, methylome, epigenome and transcriptome profiling resolve a Mendelian condition - Nature Genetics Simultaneous profiling of the genome, methylome, epigenome and transcriptome using single-molecule chromatin fiber sequencing and multiplexed arrays isoform sequencing identifies the genetic and molec...

The "kitchen sink" of omics to solve the basis for an undiagnosed disease: long read genome , transcriptome, methytome, epigenome, all synchronized (a first)
www.nature.com/articles/s41...

A reaction face meme that uses Gus Fring from Breaking Bad, two panels. First panel: Gus is happy, laughing, the text above says SOMEONE CITES YOUR PAPER. Second panel: Gus is unhappy, mad face, the text above says THE REASON WHY THEY CITE YOUR PAPER IS COMPLETELY WRONG

American science and medicine has been thrown into chaos and uncertainty over the past week. Here are some stories to get up to speed. 1/12