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Leon Schulte

@schultelab.bsky.social

Human immunology through the RNA lens. Focused on macrophages, lncRNAs & systems immunology. Professor for RNA- and infection-biology @unimarburg.bsky.social. Web: http://rna-lab.org/

56 Followers  |  97 Following  |  4 Posts  |  Joined: 22.02.2024  |  1.3324

Latest posts by schultelab.bsky.social on Bluesky

Our latest study is now out in @narjournal.bsky.social‬: we identify a post-transcriptional bottleneck in interferon gamma signaling that hinges on proper maturation of JAK2 mRNA.
Paper: academic.oup.com/nar/article/...

01.07.2025 08:22 — 👍 8    🔁 4    💬 1    📌 1
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A searchable atlas of pathogen-sensitive lncRNA networks in human macrophages Nature Communications - Long non-coding RNAs (lncRNA) are known immune regulators, yet a systemic understanding of their regulatory crosstalk is still elusive. Here the authors establish a platform...

How do long noncoding RNAs help macrophages fight bacteria? We built a whole atlas to explore this question — and it’s now published in Nature Communications!
🔗 rdcu.be/em7aM

#lncRNA #macrophage #immunology

22.05.2025 15:54 — 👍 4    🔁 2    💬 0    📌 1
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We also built SMyLR, a searchable online resource for the immune-lncRNA community:

Explore pathway dependencies, subcellular localization, and protein interactors of hundreds of lncRNAs in macrophages:
🔍 rna-lab.org/smylr/

More info in our paper:
🔗 rdcu.be/em7aM

#lncRNA #openscience #macrophage

22.05.2025 11:57 — 👍 0    🔁 0    💬 0    📌 0
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Meet GRADR: our new approach to chart lncRNA–protein interactions transcriptome-wide.

By combining gradient profiling and RNA-binding proteomics, GRADR reveals which lncRNAs engage which protein machineries.

📘 Step-by-step protocol included in:
🔗 www.nature.com/articles/s41...

#lncRNA #methods

22.05.2025 11:53 — 👍 0    🔁 0    💬 0    📌 0
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We’re now on Bluesky!
This space will share updates from our lab, covering RNA biology, macrophage immunology, and long noncoding RNAs.
Follow along for papers, resources & insights from the bench.

#lncRNA #macrophage #immunology #RNA #biomed #openscience

21.05.2025 20:21 — 👍 6    🔁 0    💬 1    📌 0

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