Semaglutide shows potential to curb cocaine addiction behaviors A new study suggests that semaglutide, a drug best known as Ozempic, may reduce cocaine use, motivation, and relapse in rats. These findings point to a possible role for GLP-1-based drugs in treating cocaine addiction.

Semaglutide shows potential to curb cocaine addiction behaviors

✈️ Travel Awards Now Open for #CPDD26! ✨
Are you a student, early-career investigator, or trainee planning to attend the 2026 CPDD Annual Meeting? Travel award applications are officially OPEN!

📅 Don’t wait — apply now and take your research journey to the next level!
🔗 cpdd.org/meetings/cur...

On the Power of Small Acts of Noncompliance At a moment when large-scale resistance can feel futile,
there are other ways to oppose, engage, and fight back.

the rare uplifting nation article (no shade to the nation) www.thenation.com/article/acti...

The New York Times piece today about US science is terrible and wrong—in many ways.

I could write a whole article about this, but as one example:

“To close observers, the original crisis began well before any of this…”
No. I’m a close observer of science, and this is incorrect.

Homepage - Population, Evolutionary, and Quantitative Genetics Conference Visit our website to learn more.

Save the date! #PEQG26 June 9-12 2026 in Asilomar, CA. Happens only every 2yrs, but is my favorite conference. Full website coming soon, and registration and abstract submission opens November 14, but I'm allowed to tease that keynotes will be @jnovembre.bsky.social @jennytung.bsky.social and me!

"We should always demand evidence—exactly what I was doing when I insisted all CDC recommendations be based on credible data, not ideology or preordained outcomes...I was fired for holding that line. But the line doesn’t disappear with me...

The psych job market isn’t dead! Join us at UIC!!! We are looking for a clinical psychologist (assistant or associate level)!! Chicago is simply the best, and the department is incredibly lovely! I’m not on search committee, but as the “newest” hire, I’m happy to talk about my experience thus far!

The New Artificial Intelligentsia | Los Angeles Review of Books In the fifth essay of the Legacies of Eugenics series, Ruha Benjamin explores how AI evangelists wrap their self-interest in a cloak of humanistic concern.

"Take the autonomous weapons systems raining hell on Palestinians—why else give them saccharine-sounding names like Lavender and the Gospel if not to make these deadly inventions seem benevolent?" 1/2 lareviewofbooks.org/article/the-...

Hey #alcohol researchers, what are non-NIH funding mechanisms to support alcohol research? Please share any information #rsa2025 #rsa_isbra2025

Rosa's excellent @cp-trendsgenetics.bsky.social piece on genome-wide association studies (GWAS) of speech, language & reading traits offers a nice opportunity to (re)post a selection of the research articles she covers. (And we are only just getting started!) .... 🧪1/n

I'm very excited that this is out as preprint. In this study, 370 participants completed up to 30 runs of reward learning. We see that BMI and and Binge eating are associated with distinct RL patterns. Includes hierarchical models using Stan (+ many hours of sampling) and MRI data of an effort task

Our paper: ""Oxygen-induced stress reveals context-specific gene regulatory effects in human brain organoids"
genome.cshlp.org/content/earl...

Our research shows how #cannabis affects the developing brain. I spoke to Dr. Delaney Ruston about how #THC exposure in adolescent rats alters cell communication vital for cognitive function.

Watch more: www.youtube.com/watch?v=f2Eb...

False positives in study of memory-related gene expression - Nature Nature - False positives in study of memory-related gene expression

Important 'Matters Arising' from @neurome.bsky.social and Zhaoxia Yu discussing false positives due to multiple comparisons in large-scale gene expression data. I applaud Eran and others who consistently raise these issues for discussion in the community.

www.nature.com/articles/s41...

And then look at yourself in the mirror and say “an orange monkey, a couch fucker, and a half baked conspiracy theorist with a worm carcass in his brain aren’t going to stop me”

And get moving ❤️🫶🏼✊🏼

📣 Latest from the lab: Performance of deep-learning-based approaches to improve polygenic scores www.nature.com/articles/s41...

Its thought deep learning will substantially improve PGS but the reality is MANY have tried but no/little gain has been seen so far. Here we report our negative results.

Drosophila Genetic Database The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...

Flybase lost all of the NIH support overnight - it is a disaster for the community. Please consider donating. I just did! www.philanthropy.cam.ac.uk/give-to-camb...

Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...

Psychiatric genome-wide association study enrichment shows promise for future psychopharmaceutical discoveries - Communications Medicine Hatoum et al. undertake exploratory analysis of genome-wide association studies of specific psychiatric disorders to find existing medications that treat those disorders and genetic pathways that may ...

Collecting large genome-wide samples may de-risk reinvestment in psychopharmaceuticals. Expanding on past work that lumped all psychiatric disorders together, we conducted a test of the utility of GWAS for specific psychiatric indications. www.nature.com/articles/s43...

Check out our new OCD GWAS (53,660 cases and 2,044,417 controls) in @natgenet.nature.com 🧬🧠

Genetic risk was associated with excitatory neurons in the cortex and hippocampus. There was much genetic overlap with anxiety, depression, and anorexia.

Open access: www.nature.com/articles/s41...

a cartoon character from the movie monsters inc is asking is it hard to stay awake ? nap time . ALT: a cartoon character from the movie monsters inc is asking is it hard to stay awake ? nap time .

New article is out! Sleep deprivation is bad for the brain transcriptome, but how quickly can a little sleep reverse this effect? A team effort and fun collaboration with @stephaniehicks.bsky.social (a thread) pubmed.ncbi.nlm.nih.gov/40315180/

Today on #WorldDNADay we honour major scientific milestones and a paradigmatic shift. Indigenous-led initiatives like @ncig2013.bsky.social are closing the genomic gap for Aboriginal and Torres Strait Islander peoples
@azurehermes.bsky.social @blackochreomics.bsky.social @hardipp.bsky.social

I wrote a thing.

I am eternally grateful for my editor, who took the original draft and helped me narrow down my key points into a more effective piece with a broader reach.

Also, thanks to the editorial & legal teams, who maintained the message while protecting us in this fraught moment.

A fun privilege of editing an @apajournals.bsky.social journal is they send you a list of the most downloaded articles each year!

Here are some notables.

I'll start with new 2024 articles in the top 20 then move to classics. There were 4 2024 articles in the top 20, most are much older.

1/

Trump’s mental health and addiction problem “What this does is reduce the profile and priority of mental health and addictions in America”: The former director of SAMHSA on the consequences of eliminating the agency.

Opinion: Due to the actions of the Trump administration, many face a bleak future in dealing with mental health problems, addictions, and trauma.

This seems like a relevant article to share with my statistics class.....

Early-life adversity alters adult nucleus incertus neurons: implications for neuronal mechanisms of increased stress and compulsive behavior vulnerability Neuropsychopharmacology - Early-life adversity alters adult nucleus incertus neurons: implications for neuronal mechanisms of increased stress and compulsive behavior vulnerability

How does early-life stress impact the brainstem nucleus incertus, and how does that influence stress- and reward-related behaviors later in life?

Learn all about it in this recent NPP paper:

www.nature.com/artic...

Harvard's decision to fight back has given me such hope!

You do not in fact have to bend the knee