Francesco Gobbo

For #FluorescenceFriday, a hippocampal neuron expressing tagBFP among ECFP astrocytes

TAX👏THE👏RICH👏

🎬 Behind the Science Spotlight - Part 2 with @britishneuro.bsky.social President Prof Tara Spires-Jones

What do fly experiments, negative data & media exposés have in common?

They’re all part of @tspiresjones.bsky.social’s story.

Excited for today's Dementia Masterclass!

@britishneuro.bsky.social

Plot twist: it's the same railway

📆 Mark your calendars: #OptoGRC2026 is headed back to Tuscany, May 10-15, 2026!

We look forward to reuniting with our amazing community for a week of great science, thoughtful discussions & shared time with colleagues.

More details coming soon👇🏽
tinyurl.com/esvrabsu

OMG that's horrible! Thank you for sharing that!

Systems consolidation reorganizes hippocampal engram circuitry Nature - A study shows that loss of memory precision associated with systems consolidation can be explained by neurogenesis-dependent reorganization of engram circuitry within the hippocampus over...

Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation.

rdcu.be/el18q

A short thread follows for those interested.

1/n

However, I don't think there's concluding evidence for that, possibly because it's unclear how this model can be falsified and therefore tested.

Well you posit that traces form on preestablished (or established upon memory formation) within the hippocampus, on something that may resonate with theories such as relational memory.

Thank you!

Thank you for your interest! It is an interesting take, perhaps you will find Widloski et al (2022) useful in this sense.

Thanks to my coauthors @simonschultz.bsky.social @tsememorylab.bsky.social @elena-faillace.bsky.social and Bsky-less Rufus, Adrian, Nuria, Adana, Patrick, Mark and Richard

Last, we inhibited this activity and found that this activity was necessary to correcly decide to go to the correct reward location, but only in allocentric animals!

Then, we used miniscopes to look into the hippocampus activity in the two tasks and found that egocentric representations were less precise

First, we developed two protocols so rats would use allocentric or egocentric coordinates

If you are a hippocampus fan 🧠, check out our new preprint on Memory and Route planning in navigation! 🍪🐀

A multi-year, multi-person effort with lots of cool stuff: behaviour🧭miniscopes🔬and optogenetics🚨

www.biorxiv.org/content/10.1...

#science #hippocampus #memory #navigation #replay #miniscopes

We are hiring! — Semantic memory Lab

We are hiring! PostDoc position on my ERC for wire-less electrophysiology in our 9mX5m rat HexMaze! Experience with tetrodes or silicone probes required. Contact me for questions! www.genzellab.com/we-are-hiring

Fight.

Living human brain tissue used to mimic Alzheimer’s in breakthrough study Exclusive: British team exposed live cells to toxic proteins to gather rare insight into how dementia develops Scientists have used living human brain tissue to mimic the early stages of Alzheimer’s disease, the most common form of dementia, in a breakthrough that will accelerate the hunt for a cure. In a world first, a British team successfully exposed healthy brain tissue from living NHS patients to a toxic form of a protein linked to Alzheimer’s – taken from patients who died from the disease – to show how it damages connections between brain cells in real time. Continue reading...

Living human brain tissue used to mimic Alzheimer’s in breakthrough study

Interested in #astrocytes, #synapse activity and loss in #AD? Come to my poster at #BNA2025 on Monday afternoon! Will also give a flash talk at 14:10. See you there!

Sex Redefined: The Idea of 2 Sexes Is Overly Simplistic Biologists now think there is a larger spectrum than just binary female and male

Human sex is not binary from a biological perspective ♀️♂️. Female/Male - as well as XX/XY - is an incomplete model to describe sex in humans. A good read about the subject 👇

🧪 #science #STEM

www.scientificamerican.com/article/sex-...

When I worked in UK academia I recall hearing of a Japanese man who was baffled at how Britain had decided to run its universities like firms. “Why? Your universities are excellent and your firms are terrible.”

The time course and organization of hippocampal replay The mechanisms by which the brain replays neural activity sequences remain unknown. Recording from large ensembles of hippocampal place cells in freely behaving rats, we observed that replay content i...

1/19 I’m thrilled that my postdoctoral work, with John Widloski and David Foster is now out in @science.org, along with a wonderful preview by Daniel Bendor!

This is a really nice review of the career of a tremendous scientist and wonderful person who will be greatly missed

I have a couple come find me on Monday:)

On print at last! #hippocampus #neuroscience

Very sad news today. We lose such a kind soul and a brilliant mind. 🫂

Day 20
#Books
#BookSky
#BookChallenge

Day 19
#Books
#BookSky
#BookChallenge