PMC Protein Modules Community

Remember to tune in next Monday (June 16) at 3pm CET. We’ll hear from Dr. Lucía Chemes (@unsamoficial.bsky.social) and Julian van Gerwen (@julianvangerwen.bsky.social).

Register to attend:
tinyurl.com/PMCseminar2

Recordings of previous seminars: www.youtube.com/@PMCModularity

PMC Modularity

You can find recordings of previous seminars here: www.youtube.com/@PMCModularity
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TIME CHANGE - Because of a public holiday, we have moved the next seminar to Monday June 16 at 3pm CET. Tune in to hear from Dr. Lucía Chemes (@unsamoficial.bsky.social) and Julian van Gerwen (@julianvangerwen.bsky.social).

Register to attend:
tinyurl.com/PMCseminar2

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Remember to tune it at 6pm CET May 12 for the next seminar in our series with Prof. Tony Hunter (@salkinstitute.bsky.social) and Dr. Jesús Alvarado-Valverde (@jesusav.bsky.social).

Register to attend:
tinyurl.com/PMCseminar2

PMC Modularity

You can find recordings of previous seminars here: www.youtube.com/@PMCModularity

We are currently reviewing the timing of the seminar series. If you have any thoughts, please fill out this form: forms.gle/xH9hLk5ZM994...
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Join us at 6pm CET May 12 for the next seminar in our series with Prof. Tony Hunter (@salkinstitute.bsky.social) and Dr. Jesús Alvardo Valverde (@jesusav.bsky.social).

Register to attend:
tinyurl.com/PMCseminar2
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PMC Seminar feedback Thank you for your interest in our seminar series! Whether you've been able to attend or were interested but unable to join us, we value your feedback. Your input will help us improve future sessions ...

Thanks to everyone who has attended the PMC seminars!

We have decided to review the timing of the seminar series. If you have any thoughts about the timing of the seminars (currently 6-7pm CET every 2nd Mon of the month), please fill out this form: forms.gle/VZkU2fWkswxY...

Thanks for your input!

Remember to join us at 6pm CET April 14 for the next seminar in our series with Prof. Anne-Claude Gingras (@uoft.bsky.social) and Dr. Veronica Venafra.

Register to attend: tinyurl.com/register-pmc-seminar

You can find recordings of previous seminars here: www.youtube.com/@PMCModularity

Plasma membrane-associated ARAF condensates fuel RAS-related cancer drug resistance - Nature Chemical Biology ARAF uniquely enhances RAS activity via N-terminal disordered sequence, forming membrane ARAF–RAS condensates that shield RAS from negative regulation and drive cancer drug resistance.

ARAF uniquely enhances RAS activity via its N-terminal disordered sequence, forming membrane ARAF-RAS condensates that shield RAS from negative regulation and drive cancer drug resistance

www.nature.com/articles/s41...

PMC Modularity

You can find recordings of previous seminars here: www.youtube.com/@PMCModularity

Please reach out if you have any feedback on the seminars!
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Join us at 6pm CET April 14 for the next seminar in our series with Prof. Anne-Claude Gingras (@uoft.bsky.social) and Dr. Veronica Venafra.

Register to attend: tinyurl.com/register-pmc-seminar
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Figure from the paper illustrating sequence–ensemble–function relationships for disordered proteins. ML prediction (black) and design (orange) approaches are highlighted on the connecting arrows. Prediction of properties/functions from sequence (or vice versa, design) can include biophysics approaches via structural ensembles, or bioinformatics approaches via other hetero- geneous sources. The lower panels show examples of properties and functions of IDRs for predictions or design targets. ML, machine learning; IDRs, intrinsically disordered proteins and regions.

Our review on machine learning methods to study sequence–ensemble–function relationships in disordered proteins is now out in COSB

authors.elsevier.com/sd/article/S...
Led by @sobuelow.bsky.social and Giulio Tesei

PMC Modularity

You can find recordings of previous seminars here: www.youtube.com/@PMCModularity

Please reach out if you have any feedback on the seminars!

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Remember to join us at 6pm CET Mar 10 for the next seminar in our series with Dr. Dezső Módos (@imperialcollegeldn.bsky.social ) and Dr. Joanna Koszela (@uofglasgow.bsky.social ).

Register to attend: tinyurl.com/register-pmc-seminar

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Enjoying #BPS2025! I'll present my development of a ML predictor of domain–peptide binding affinity to understand how affinity is optimized across the proteome for cell signaling. Finish out the meeting by coming to my talk tomorrow (Wed) @ 1pm!

PMC Modularity

You can find recordings of previous seminars here: www.youtube.com/@PMCModularity

Please reach out if you have any feedback on the seminars!

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Remember to join us on Monday Feb 10 at 6pm CET for the first session of our online seminar series!

Register to attend: tinyurl.com/register-pmc-seminar

Foldseek-Multimer—now published in @naturemethods.bsky.social—our fast multimer search tool, enables complex comparisons against the full PDB in seconds. It comes with BFMD, a collection of 300K+ predictions gathered from community projects.
📄 nature.com/articles/s41...
🌐 search.foldseek.com

Flyer for the course Keeping up with the interactome - How IDPs work including a list of speakers: Professor Tanja Mittag, St Jude Children’s Hospital, Memphis, US Professor Kresten Lindorff-Larsen, BIO, SCIENCE, UCPH Professor Ylva Ivarsson, Uppsala University, Sweden Dr. Michael Wehr, Systasy Bioscience, Munich, Germany Professor Zsuzsanna Dostztányi, Eötvös Loránd University, Hungary Professor Kristian Strømgaard, HEALTH, UCPH Professor Stefano Gianni, Sprienza University of Rome, Italy Professor Per Jemth, Uppsala University, Sweden Dr. Franziska Schöppe, Novo Nordisk A/S, Denmark Professor Benjamin Schuler, University of Zurich, Switzerland Professor Alfonse De Simone, University of Naples, Italy Dr. Malene Ringkjøbing Jensen, CNRS, Grenoble, France Alleyn Plowright, Chief Scientific Officer, Pangea Bio, London UK Professor Birthe B. Kragelund, BIO, SCIENCE, UCPH

If you are a PhD student and like protein disorder (or want to learn more), Birthe Kragelund @bbkrage.bsky.social and Kristian Strømgaard are organizing a PhD course on How IDPs work 🧶🧬🧪 Note the cost if you are not at a Danish university.

Details: phdcourses.ku.dk/DetailKursus...

PhosX: data-driven kinase activity inference from phosphoproteomics experiments AbstractSummary. The inference of kinase activity from phosphoproteomics data can point to causal mechanisms driving signalling processes and potential dru

Kinases play a role in many diseases, making them prime targets for therapeutic intervention.

Enter PhosX, a new tool transforming the way researchers analyse and interpret kinase activity.

Read the full article: academic.oup.com/bioinformati...

@alussana.bsky.social @epetsalaki.bsky.social

Join us in Vienna 8-9 May for the #Ubiquitin & Friends Symposium 2025! Excellent line-up of guest speakers👇And many slots for talks from abstracts, plus flash-talks & posters! Lots of opportunities to network with peers & experts in a friendly atmosphere! ➡️ www.protein-degradation.org/symposium/

Join us for our new online seminar series, featuring two talks on protein modules every month! The first session kicks off at 6pm CET Feb 10 with Dr. Gergő Gógl and Dr. Ugo Dionne.

Register to attend: tinyurl.com/register-pmc-seminar