Magnus Kjærgaard

2026 Intrinsically Disordered Proteins Conference GRC The 2026 Gordon Research Conference on Intrinsically Disordered Proteins will be held in Les Diablerets, Vaud (fr) Switzerland. Apply today to reserve your spot.

🚨🚨The GRC on Intrinsically Disordered Proteins #IDPs is back!! 🍝🧵🏔️Join us for cutting-edge IDP science, great discussions, and mountain views 🌄🍝
📅 June 21-26, 2026 | Les Diablerets, Switzerland
👉 Details & registration: grc.org/intrinsicall...

Would you like to hear about our work developing a screening pipeline for de novo designed binders us the microfluidic sizing?

Then tune in on Thursday for a virtual seminar. Sign-up below:

fidabio.webinargeek.com/how-to-scree...

As FIDA relies on changes in hydrodynamics radius, it works best for small targets such as motifs from IDPs.

Luckily, this is what we intended to use it for 😉

Medium throughput protein expression and purification for protein design using heat lysis This protocols describes medium throughput protein expression in E. coli using heat-lysis as a built in purification step. It is intended for preparation of heat-stable de novo...

Crucial to the screening is the lab scale protein expression pipeline below.

We use an old trick beloved by the IDR-community for protein purication: Heat lysis.

Due the thermostability of the binders, we get ~95% pure lysate after a heating step in 96-well plates.

dx.doi.org/10.17504/pro...

Screening de novo designed protein binders in unpurified lysate using flow induced dispersion analysis Computational protein design can create binders against targets of interest, but identifying binders with sufficient affinity still requires biochemical screening of many designs. In this work, we te....

Experimental verification is increasingly the bottleneck in protein design projects.

In this paper, we develop a new mini-binder screening pipeline based on the microfluidic sizing technique called flow-induced dispersion analysis (FIDA).

doi.org/10.1002/pro....

The technique works best for small targets with a large change in radius of hydration upon binding – e.g. SLiMs in IDPs 😊 – but also works for larger proteins with only a 10% change in RH upon binding.

We find that it works excellently with “boiling lysis” – exploiting the high thermostability of binder designs to remove endogenous proteins – and then simply dilution the supernatant with buffer before measurement.

FIDA measure radius of hydration based on diffusion in a microfluidic capillary.

This allows us to pick out successful binders based on the increase in R_H – a one-point measurement for initial screening and titration for affinity determination.

How do we screen do novo designed binders most efficiently? In this pre-print, we show that the microfluidic sizing technique FIDA allows us to pick successful binders in a single measurement using minimal sample:

www.biorxiv.org/cgi/content/...

Sarah Shammas (University of Oxford):Opportunities in DNA binding provided by protein disorder Sonia Longhi (AFMB Marseille): Intrinsic disorder, phase transitions and fibril formation by the Henipavirus V and W proteins: a new hallmark of viral pathogenesis?

IDPSeminars is back with another seminar this week from @sarahshammas.bsky.social and @sonia-longhi.bsky.social!

Come hear about transcriptional regulation and viral pathogenesis!

Thursday June 5th!
PST 10 am EST 1 pm CET 7 pm!

Info: idpseminars.com
Signup form: forms.gle/3yCHeYvuuqLh...

Reactionaries hate universities because they create open-minded liberated people open.substack.com/pub/iandunt/...

Our annual report 2024 is out!
Dive into our research highlights, talent development, collaborations, and new events and initiatives.

dandrite.au.dk/annual-repor...

Postdoc: De novo protein design for neuroscience - Ledig stilling på Aarhus Universitet Ledig stilling ved Institut for Molekylærbiologi og Genetik - Neurobiologi, Aarhus Universitet

🚨We have an opening for a postdoc to use protein design techniques to developing and characterizing binders against intrinsically disordered proteins involved in neuroscience.

Experience in protein biochemistry and/or molecular neuroscience preferred.

Share: 🙏

mbg.au.dk/aktuelt/ledi...

The most wholesome Fox News show: 5 fox cubs playing in our garden.

Tenure-Track Assistant Professor / Associate Professor in Bioinformatics at Aarhus University, Denmark - Vacancy at Aarhus University Vacancy at Department of Molecular Biology and Genetics - BiRC - Bioinformatics Research Center, Aarhus University

📣 🥳 🧑‍💻 Our department is hiring:

Tenure-Track Assistant Professor / Associate Professor in Bioinformatics at Aarhus University, Denmark

Deadline June 1st

Thanks for sharing!

mbg.au.dk/en/news-and-...

Baby fox in the garden!

Trigger warning: FOMO

How often do you go to a conference where you are excited about EVERY SINGLE TALK! Well, I guess it helps if you get to make the program. 😀

"Biomolecular condensates: From fundamental principles to applications in health and biotech" kicking off at 9 AM!

Probably the best conference venue in Denmark?

Tomorrow, we kick-off our condensate meeting in the Carlsberg Academy ⬇️.

Thank you to the Novo Nordisk Foundation for the grant to host our dream meeting, and to the Carlsberg Foundation for hosting us at this beautiful site.

We have a new review/perspective on the potential of biomolecular condensates in microbial cell factories. The emphasis is on the trade-offs that have to be navigated when designing such synthetic organelles.

1968 Thule Air Base B-52 crash - Wikipedia

Since the Trump team are making videos about US-Greenland history, maybe the next one could be about that time when USAF crashed a B-52 spilling four nuclear bombs - one of which his probably never been recovered:
en.m.wikipedia.org/wiki/1968_Th...

Dear American friends.

We agree that status quo in the Artcic is not an option.

So let’s talk about how we can fix it - together.

Lars Løkke Rasmussen
Danish Foreign Minister

The bulk of the prize comes in the form of a grant for educational development.

We plan to use this to integrate computational skills - mainly python and R - across the whole curriculum. The prize allows us to hire someone the spearhead this across all the courses in our department!

This is part of a new series of teaching prizes spanning from primary school to university level by the Novo Nordisk Foundation.

Seen from the outside, it looks like a 💰-push to increase the public and institutional recognition of teaching. Interesting to see how this will evlve.

Three Educators from MBG Receive the Novo Nordisk Foundation Prize for Natural Science Teachers at Universities Magnus Kjærgaard, Gregers Rom Andersen, and Ditlev Egeskov Brodersen teach biochemistry and structural biology to students at the Department of Molecular Biology and Genetics. Now, they are receiving ...

Surprised - in a good way - to find myself as a recipient of a big teaching national prize within Natural Science together with good colleagues @ditlevbrodersen.bsky.social and Gregers Rom Andersen.

nat.au.dk/en/about-the...

IDPSeminars is back this week (Tomorrow, March 6th)! Come hear about nucleolar organization and IDRs in host-pathogen interactions!

PST 10 am
EST 1 pm
CET 7 pm!

Info: idpseminars.com
Signup form: forms.gle/3yCHeYvuuqLh...

Authoritarianism runs strong in this family. It is an utter disgrace.

The world order has changed. The US is no longer the leader of the free world.

The key question going forward: Who is?

Which side of history do our politicians choose - and who will lead?

The United States is giving up strong alliances, prosperous trade relationships, checks and balances, the rule of law and democratically-accountable government in order to become the Belarus of North America.

Welcome to the American Oblast of the Russian Federation.

Congrats to Alain for napping a Marie Curie postdoc fellowship to work on condensates!

2nd Curie fellowship for the lab after @mcd611.bsky.social got one last year!

Who will be number 3? 😏

Announcing the Biophysics Week IDP Trainee Symposium on March 27 at 12pm CT hosted by @idpseminars.bsky.social & The BPS IDP Subgroup! Join via Zoom for talks by talented grad students & postdocs. Abstract submissions are open! See flyer for more details! #BiophysicsWeek @biophysicalsoc.bsky.social

Two Faculty positions (Associate Professor or Tenure-Track Assistant Professor) at Aarhus University, Denmark. Molecular Medicine and/or Molecular Biology - Ledig stilling på Aarhus Universitet Ledig stilling ved Institut for Molekylærbiologi og Genetik, Aarhus Universitet

We are recruiting two new colleagues at the department of Molecular Biology. Come join us! Denmark is a great place to live, science funding is really good, and the people are nice. Message me if you have any questions

mbg.au.dk/aktuelt/ledi...