Spectral decomposition of local field potentials uncovers frequency-tuned gain modulation of working memory in primate visual system Working memory has been shown to modulate visual processing in a variety of ways, including changes in visual response gain, oscillatory power, spike timing, and phase coding of information[1][1]–[3][...

Spectral decomposition of local field potentials uncovers frequency-tuned gain modulation of working memory in primate visual system
doi.org/10.1101/2025...
#neuroscience

This surprisingly relaxing footage is from SIX MILES under the ocean – and it’s the deepest ecosystem yet discovered

A molecular machine directs the synthesis of a catenane Precise mechanical manipulation of molecules is inherently difficult owing to random thermal motion. Although directed movement on the molecular scale has been achieved, using it to impose specific—es...

Oh, you have a machine that goes bing? Well guess what chemsky? @science.org has a machine that goes RING! On the cover this week, Michael Kathan’s group use a Feringa-type rotary motor to produce catenanes! 🧪

www.science.org/doi/10.1126/...

Connectomics 2.0: Simulating the brain With a complete fly connectome in hand, researchers are taking the next step to model how brain circuits fuel function.

It took more than a decade to trace the 130,000 connections in a fruit fly's brain. With the map in hand, researchers are turning to the next step in connectomics: building simulations.

By @ldattaro.bsky.social

#neuroskyence

www.thetransmitter.org/connectome/c...

Null and Noteworthy: Neurons tracking sequences don’t fire in order Instead, neurons encode the position of sequential items in working memory based on when they fire during ongoing brain wave oscillations—a finding that challenges a long-standing theory.

The neurons that encode sequential information into working memory do not fire in that same order during recall, a finding that is at odds with a long-standing theory. Read more in this month’s Null and Noteworthy.

By @ldattaro.bsky.social

#neuroskyence

www.thetransmitter.org/null-and-not...

Null and Noteworthy: Downstream brain areas read visual cortex signals en masse in mice The finding contradicts a theory that the regions prioritize neurons that are adept at identifying specific stimuli. Plus, a response to a study that questioned immune memory in astrocytes.

Some neurons respond more strongly to visual stimuli than others. But the rest of the brain doesn’t prioritize signals from those neurons, according to a new study. Read more in this month’s Null and Noteworthy.

By @ldattaro.bsky.social

#neuroskyence

www.thetransmitter.org/null-and-not...

It was a steep climb in the "early days" (~2012) up the ImageNet gradient towards better visual system models. That tapped out ~2015 after resnet ...

But now w/ video models starting to perform, we can push forward again. Task-driven brain models ftw. amazing...

@mschrimpf.bsky.social

Physicists disagree wildly on what quantum mechanics says about reality, Nature survey shows First major attempt to chart researchers’ views finds interpretations in conflict.

This year quantum physics turns 100, so @nature.com decided to conduct the biggest ever survey of what lies behind it. Do physicists really believe in multiple universes? Can influences happen instantaneously? Is the Copenhagen interpretation all it's cut out to be? ⚛️🧪 www.nature.com/articles/d41...

New dopamine sensor powers three-color imaging in live animals The tool leverages a previously unused segment of the color spectrum to track the neurotransmitter and can be used with two additional sensors to monitor other neurochemicals at different wavelengths.

A new molecular sensor leverages a previously unused segment of the color spectrum to track dopamine and can be used together with two additional sensors that monitor other neurochemicals at different wavelengths.

By @dianakwon.bsky.social

#neuroskyence

www.thetransmitter.org/methods/new-...

Eye puffs prompt separable sensory, affective brain responses in mice, people Post-puff brain state might not be an emotion, some researchers caution, but the protocol provides a cross-species approach to study emotions.

Can we study emotion by using eye puffs that are "irritating"?
Check this Transmitter piece about the original paper in Science and some views for an against.
@thetransmitter.bsky.social
#neuroskyence
www.thetransmitter.org/emotion-proc...

A neural manifold view of the brain - Nature Neuroscience Recent advances in neuroscience have revealed how neural population activity underlying behavior can be well described by topological objects called neural manifolds. Understanding how nature, nurture...

Check out our new review/perspective (w/ @juangallego.bsky.social & Devika Narain) on neural manifolds in the brain! It was a lot of fun to think through these ideas over the past couple of years, and I'm excited it's finally out in the world!

🔗: www.nature.com/articles/s41...
📄: rdcu.be/ex8hW

Eye puffs prompt separable sensory, affective brain responses in mice, people Post-puff brain state might not be an emotion, some researchers caution, but the protocol provides a cross-species approach to study emotions.

A cross-species study captured an emotional brain state characterized by lingering brain activity in higher-order areas. “It’s one of those moments where you’re getting a first glimpse at a vast and complex landscape,” says @deisseroth.bsky.social.

By @callimcflurry.bsky.social

bit.ly/3U33raF

Magnon spectroscopy in the electron microscope - Nature A method combining scanning transmission electron microscopy with high-resolution electron energy-loss spectroscopy enables the observation of magnons and their dispersion, and provides a way to examine magnetic inhomogeneities with nanometre spatial resolution.

Nature research paper: Magnon spectroscopy in the electron microscope

go.nature.com/44MDNgH

Living Systems are Not Like Machines: A Conversation with Nobel Laureate, Paul Nurse, Part Two SIR PAUL NURSE | Human beings like things to be ordered. That's how we are. But maybe cells and living things are more sloppy. Perhaps the cell has to be sloppy to avoid, as I said, getting stuck...

The second part of my conversation with Sir Paul Nurse on the state of play in molecular and cell biology, hosted by The Marginalia Review of Books, is now online.
www.marginaliareviewofbooks.com/post/__tbd-1

A neural manifold view of the brain - Nature Neuroscience Recent advances in neuroscience have revealed how neural population activity underlying behavior can be well described by topological objects called neural manifolds. Understanding how nature, nurture...

www.nature.com/articles/s41...

Octopuses Fall For The Classic Fake Arm Trick – Just Like We Do Octopuses can be fooled into thinking a fake arm is actually their own.

“Octopuses can be fooled into thinking a fake arm is actually their own.
When scientists in Japan pinched an artificial appendage during experiments, octopuses recoiled in defense – swimming away, suddenly changing their color, or retracting their arms”

www.sciencealert.com/octopuses-fa...
🧪 🐙 🦑

Brain Surfaces of 70 primate species

1
To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!

🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...

On the Explanation of Intentionality It is a widespread assumption in contemporary philosophy of mind that a naturalistic explanation of intentionality must answer to what I will call the ‘question of aboutness’: what makes it the cas...

My paper 'On the Explanation of Intentionality' has just been published in the Australasian Philosophical Review www.tandfonline.com/doi/full/10....

⚡️🧠A nociceptive amygdala-striatal pathway modulating affective-motivational pain

Now published on the cover of Science Advances @science.org

Check it out 👇
www.science.org/doi/10.1126/...

How to build a truly global computational neuroscience community Computational sciences offer an opportunity to increase global access to, and participation in, neuroscience. Neuromatch’s inclusive, scalable model for community building shows how to realize this…

Computational sciences can offer a unique opportunity for democratized access and participation, but we are currently falling far short of that goal, writes @neuromatch.bsky.social's @meganakpeters.bsky.social and Bradley Roberts‬‬‬‬.

#neuroskyence

www.thetransmitter.org/education/ho...

graphical abstract of the article the extended mobility of plasmids

Here's our new broad review on the extended mobility of plasmids, about all mechanisms driving and limiting their transfer. From conjugation to conduction, phage-plasmids to hitchers, molecular to evolutionary dynamics, ecology to biotech. The state of affairs. 1/9 academic.oup.com/nar/article/...

Does the culture you grow up in shape the way you see the world? In a new Psych Review paper, @chazfirestone.bsky.social & I tackle this centuries-old question using the Müller-Lyer illusion as a case study. Come think through one of history's mysteries with us🧵(1/13):

Is visual perception WEIRD? The Muller-Lyer illusion and the Cultural Byproduct Hypothesis: http://osf.io/y7mtf/

Quantifying funding sources across neuroscience labs We want to hear from you about the sources of funding for your research.

@thetransmitter.bsky.social wants to hear from neuroscience PIs around the world to find out where they get their funding for basic research.

#neuroskyence

www.thetransmitter.org/funding/quan...

How the brain shifts between external and internal attention Nobre and Gresch call for an upgrade of attention research by considering how the brain shifts its focus between contents in the external sensory stream and internal memory representations. They highl...

How the brain shifts between external and internal attention
www.cell.com/neuron/fullt...
#neuroscience

Neural models for detection and classification of brain states and transitions - Communications Biology A deep learning self-supervised hybrid CNN-autoencoder model is used to detect brain states and transitions, like wakefulness, slow oscillations and microarousals, during the emergence from anesthesia...

Neural models for detection and classification of brain states and transitions
www.nature.com/articles/s42...
#neuroscience

Endogenous and exogenous attentional interplay through mixed prefrontal cortex resources Di Bello et al. reveal that some neural resources in lateral PFC are shared between motor and attentional systems, enabling focus to flexibly shift in response to internal goals or external demands.

Endogenous and exogenous attentional interplay through mixed prefrontal cortex resources
www.cell.com/current-biol...
#neuroscience

Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice Procedures were developed to perform mesoscale 2-photon Ca2+ imaging simultaneously from all of mouse dorsolateral neocortex, facilitating identification of widespread neural ensembles with activity r...

I'm pleased to announce that the Version of Record of our eLife paper, "Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice" (Vickers and McCormick, 2024) is now available at: elifesciences.org/articles/94167 (94167.3, VOR).

Dynamical independence reveals anaesthetic specific fragmentation of emergent structure in neural dynamics Conscious experience depends on the coordinated activity of neural processes that span multiple scales--from synapses to whole-brain dynamics. A recently introduced measure, dynamical independence, id...

📜🪇[PUBLISHED]: NEW PREPRINT!🪇📜

I am incredibly excited to announce that we have published our paper on how "Dynamical independence reveals anaesthetic specific fragmentation of emergent structure in neural dynamics"
w@thomasandrillon.bsky.social @anilseth.bsky.social Barnett, Carter

Strap in!
1/n

Imaging high-frequency voltage dynamics in multiple neuron classes of behaving mammals TEMPO optical voltage sensing in fiber-optic and mesoscope imaging formats captures transmembrane voltage dynamics, oscillations, and waves in targeted neuron types of freely moving and head-fixed beh...

Wow

www.cell.com/cell/fulltex...