Tomás Ryan's Avatar

Tomás Ryan

@tjryan.bsky.social

Neuroscientist| Professor at Trinity College Dublin | CIFAR Global Scholar| P.I. of Ryan Lab at Trinity College Institute of Neuroscience. @tjryan.bsky.social

1,713 Followers  |  1,949 Following  |  117 Posts  |  Joined: 22.10.2023  |  2.3212

Latest posts by tjryan.bsky.social on Bluesky

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Meet the #MCCS25 speakers!

Don't miss talks from Drs. Satoshi Kida and @karynfrick.bsky.social on November 14.

Register now: event.fourwaves.com/MCCS25/pages

17.10.2025 14:46 — 👍 3    🔁 1    💬 0    📌 0
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🚨Open position at #FENS!

💭Do you want to help strengthen the voice of #neuroscience?
Apply for the Advocacy and Engagement Internship at FENS!

🗓️ The deadline for applications is 31 October!
👉 https://loom.ly/2Qy18y8

16.10.2025 16:00 — 👍 2    🔁 3    💬 0    📌 0
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📣 The #MCCS25 abstract submission deadline has been EXTENDED!

Trainees, get your abstracts in by October 20 to be selected as a speaker! #Neuroskyence

More information and registration here:
event.fourwaves.com/MCCS25/pages

📍Note the poster location change!

15.10.2025 17:33 — 👍 1    🔁 2    💬 0    📌 0
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Check out the Oct 2025 issue of TINS:
www.cell.com/issue/S0166-...

Featured articles & more:
cell.com/trends/neuro...

Cover article: ‘The cost of remembering: engram competition as a flexible mechanism of forgetting’ by Livia Autore, Michael Drew & @tjryan.bsky.social
www.cell.com/trends/neuro...

14.10.2025 17:19 — 👍 15    🔁 3    💬 1    📌 0
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The Brain as a Strategic Asset: Securing Europe’s Future Through Innovation and Health – European Brain Council (EBC) On 14 October 2025, join us for “The Brain as a Strategic Asset”. With neurological and mental disorders representing a leading cause of disability and costing the European Union between €800 billion ...

🔴 On 14 October (16:30 - 18:00), join us for the opening of the Brain Innovation Days.

Hosted by MEPs Zdechovsky & Sokol, this discussion will explore how brain health can drive Europe’s resilience, competitiveness and innovation.

🔗 Register now: www.braincouncil.eu/event/the-br...

13.10.2025 08:54 — 👍 3    🔁 2    💬 0    📌 0
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Meet the #MCCS25 speakers!

Drs. @briandias.bsky.social and Sheena Josselyn will be speaking at our Symposium on November 14.

Register now: event.fourwaves.com/MCCS25/pages

09.10.2025 15:01 — 👍 3    🔁 1    💬 0    📌 0
Group photo in front of old church in green scenery

Group photo in front of old church in green scenery

The Neuroscience School for Advanced Studies "Brain Plasticity: Neural Basis of Individuality" led by LIP Director Ulman Lindenberger and Tobias Bonhoeffer @mpiforbi.bsky.social has just ended at San Servolo, Venice! #nsas

04.10.2025 07:50 — 👍 12    🔁 4    💬 1    📌 1
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🧠 Wrapping up #BrainDays at #UNGA80!

From borderless research to brain capital & governance, 25–26 Sept brought global leaders together to push brain health to the center of policy, science & society.

🔗 Highlights: www.braincouncil.eu/event-highli...

02.10.2025 08:58 — 👍 2    🔁 3    💬 0    📌 0
Patterns of c-Fos expression in the SC, PAG, and HPC reveal a loss of activity in the SC and PAG following extinction-updating but persistent activity of the vCA1. Top left: Engram labeling strategy. Bottom: TRAP2xAi32 mice underwent one of three types of behavioral paradigms; re-exposure (n = 6 mice) vs. no re-exposure (n = 6 mice), extinction (n = 7 mice) vs. innate (n = 8 mice), or updating (n = 11 mice) vs. innate (n = 8 mice). Mice were injected with 4-OHT to transiently induce c-Fos dependent EYFP upon first exposure to the looming stimulus, and later perfused 60 min following stimulus presentation at the end of the behavioral paradigm. Tolp right: Example histology from the SC, with an EYFP+c-Fos+ cell highlighted by the white arrow.

Patterns of c-Fos expression in the SC, PAG, and HPC reveal a loss of activity in the SC and PAG following extinction-updating but persistent activity of the vCA1. Top left: Engram labeling strategy. Bottom: TRAP2xAi32 mice underwent one of three types of behavioral paradigms; re-exposure (n = 6 mice) vs. no re-exposure (n = 6 mice), extinction (n = 7 mice) vs. innate (n = 8 mice), or updating (n = 11 mice) vs. innate (n = 8 mice). Mice were injected with 4-OHT to transiently induce c-Fos dependent EYFP upon first exposure to the looming stimulus, and later perfused 60 min following stimulus presentation at the end of the behavioral paradigm. Tolp right: Example histology from the SC, with an EYFP+c-Fos+ cell highlighted by the white arrow.

How do we balance innate responses & adaptive learning when reacting to threats? @tjryan.bsky.social &co show that repeated exposure to looming stimuli reduces innate defensive responses via #hippocampal modulation, revealing a vCA1 engram needed for learned #fear @plosbiology.org 🧪 plos.io/4pNSnNp

29.09.2025 16:56 — 👍 5    🔁 4    💬 1    📌 0
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🧠 Day 2 of the 2025 Brain Days: From Lifespan to the Future of #BrainHealth Policy

Building on Day 1's momentum, Sept 26th explores brain health across all life stages and charts the path toward coordinated global policy action beyond #UNGA80.

👉 braincouncil.eu/programme-un...

15.09.2025 09:06 — 👍 5    🔁 2    💬 0    📌 0
Patterns of c-Fos expression in the SC, PAG, and HPC reveal a loss of activity in the SC and PAG following extinction-updating but persistent activity of the vCA1. Top left: Engram labeling strategy. Bottom: TRAP2xAi32 mice underwent one of three types of behavioral paradigms; re-exposure (n = 6 mice) vs. no re-exposure (n = 6 mice), extinction (n = 7 mice) vs. innate (n = 8 mice), or updating (n = 11 mice) vs. innate (n = 8 mice). Mice were injected with 4-OHT to transiently induce c-Fos dependent EYFP upon first exposure to the looming stimulus, and later perfused 60 min following stimulus presentation at the end of the behavioral paradigm. Tolp right: Example histology from the SC, with an EYFP+c-Fos+ cell highlighted by the white arrow.

Patterns of c-Fos expression in the SC, PAG, and HPC reveal a loss of activity in the SC and PAG following extinction-updating but persistent activity of the vCA1. Top left: Engram labeling strategy. Bottom: TRAP2xAi32 mice underwent one of three types of behavioral paradigms; re-exposure (n = 6 mice) vs. no re-exposure (n = 6 mice), extinction (n = 7 mice) vs. innate (n = 8 mice), or updating (n = 11 mice) vs. innate (n = 8 mice). Mice were injected with 4-OHT to transiently induce c-Fos dependent EYFP upon first exposure to the looming stimulus, and later perfused 60 min following stimulus presentation at the end of the behavioral paradigm. Tolp right: Example histology from the SC, with an EYFP+c-Fos+ cell highlighted by the white arrow.

How do we balance innate responses & adaptive learning when reacting to threats? @tjryan.bsky.social &co show that repeated exposure to looming stimuli reduces innate defensive responses via #hippocampal modulation, revealing a vCA1 engram needed for learned #fear @plosbiology.org 🧪 plos.io/4pNSnNp

25.09.2025 16:53 — 👍 15    🔁 5    💬 0    📌 1
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Meet the #MCCS25 officers!

Dr. Jennifer Tudor‬ is an associate professor at St. Joseph's University. Her lab is interested in how sleep and disease affect the neural pathways critical for memory & learning.

Join us on November 13 & 14. Register here: event.fourwaves.com/MCCS25/pages

16.09.2025 14:45 — 👍 3    🔁 1    💬 0    📌 0
Lineup of speakers with headshots.

Lineup of speakers with headshots.

Check out the meeting lineup for #MCCS25! It's going to be an incredible day.

Don't miss out, register now: event.fourwaves.com/MCCS25/pages

05.09.2025 14:38 — 👍 11    🔁 9    💬 0    📌 0
Headshot of Farah and role as MCCS Treasurer

Headshot of Farah and role as MCCS Treasurer

Meet the #MCCS25 officers!

Dr. @flubinlab.bsky.social is a distinguished professor at the University of Alabama at Birmingham. Her lab studies the molecular and genetic basis of learning & memory and related disorders.

Join us on November 13 & 14. Register here: event.fourwaves.com/MCCS25/pages

10.09.2025 14:45 — 👍 3    🔁 2    💬 0    📌 0
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Meet the #MCCS25 officers!

Dr. @karynfrick.bsky.social‬ is a distinguished professor at the University of Wisconsin-Milwaukee. Her lab seeks to understand how sex-steroid hormones, aging & the environment affect memory.

Join us November 13 & 14. Register here: event.fourwaves.com/MCCS25/pages

03.09.2025 14:35 — 👍 5    🔁 2    💬 0    📌 0

Important food for through here on #generativeAI in higher education.

This forces us to fundamentally reevaluate how we conceive and practice university teaching and assessment.

04.09.2025 10:01 — 👍 4    🔁 0    💬 0    📌 0

Updated (final) preprint below:

www.biorxiv.org/content/10.1...

01.09.2025 08:25 — 👍 18    🔁 1    💬 0    📌 1
Headshot of Denise Cai with her title and a fun fact that she almost quit science to try out for master chef.

Headshot of Denise Cai with her title and a fun fact that she almost quit science to try out for master chef.

Meet the #MCCS25 officers!

Dr. @denisejcai.bsky.social is an Associate Professor at the Icahn School of Medicine at Mount Sinai. Her lab studies the neural underpinnings of learning & memory and develops imaging tools 🧠

Join us on November 13 & 14. Register here: event.fourwaves.com/MCCS25/pages

25.08.2025 17:56 — 👍 6    🔁 1    💬 0    📌 0
Una Mullally: In Trump’s America, daily life goes on amid a sense of foreboding creep People say ‘who knows what will happen?’ while knowing exactly what is going to happen

Wrote about watching the incredible Russian documentary My Undesirable Friends - Part I: Last Air in Moscow with an audience in New York, where a record of the recent past that speaks to an American future was processed in the present.

25.08.2025 12:48 — 👍 3    🔁 2    💬 0    📌 0
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Delve into the developing brain at "Back to Basics: Components & Mechanisms of Memory Development." From infant fMRI to rodent studies on amnesia, this symposium explores how the memory network, especially the hippocampus, changes across the lifespan. Join us! #FluxCongress2025

24.08.2025 17:03 — 👍 5    🔁 3    💬 0    📌 0

Excited for MCCS this year! Join us in November 🤓🧠

11.08.2025 18:39 — 👍 6    🔁 1    💬 0    📌 0

Join us in San Diego this November for #MCCS25, including 16 X research talks and the MCCS debate.

Invited faculty speakers are announced below. Half of speakers will be selected from submitted abstracts.

Registration is open:

20.08.2025 05:25 — 👍 7    🔁 4    💬 1    📌 0

Including invited speakers: @briandias.bsky.social, @karynfrick.bsky.social, @sjo09.bsky.social, Satoshi Kida, Priya Rajasethupathy, @crezaval.bsky.social, @biancasilvalab.bsky.social, & Kay Tye.

Also @andrefenton.bsky.social & Yaniv Ziv for the MCCS debate.

20.08.2025 05:25 — 👍 5    🔁 1    💬 0    📌 0

Join us in San Diego this November for #MCCS25, including 16 X research talks and the MCCS debate.

Invited faculty speakers are announced below. Half of speakers will be selected from submitted abstracts.

Registration is open:

20.08.2025 05:25 — 👍 7    🔁 4    💬 1    📌 0
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The cost of remembering: engram competition as a flexible mechanism of forgetting The retention and use of long-term memories is crucial for adaptive behavior. While stable memories help organisms anticipate outcomes, they may become maladaptive if not updated to reflect new condit...

The cost of remembering: engram competition as a flexible mechanism of forgetting.

Our new perspective piece in @cp-trendsneuro.bsky.social, lead by Ryan Lab alumni, Livia Autore. Also with Michael Drew from @utaustin.bsky.social

Trends in Neurosciences www.cell.com/trends/neuro...

15.08.2025 08:59 — 👍 72    🔁 19    💬 1    📌 1

Job Alert!!! We are looking for a motivated postdoc to join a 3-year BBSRC funded project led by my colleague Carl Stevenson (I’m coPI). This multi-disciplinary project will combine in vivo heart rate monitoring and optogenetics with behavioural testing (fear and active avoidance) in rats.

13.08.2025 14:55 — 👍 12    🔁 10    💬 1    📌 4
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Karen Hao on AI tech bosses: ‘Many choose not to have children because they don’t think the world is going to be around much longer’ The author of Empire of AI: Inside the Reckless Race for Total Domination discusses the cost of Big Tech’s huge investment in technologies that may do more harm than good

Karen Hao on AI tech bosses: ‘Many choose not to have children because they don’t think the world is going to be around much longer’

09.08.2025 11:05 — 👍 316    🔁 108    💬 23    📌 91

“A legitimate PhD-level expert in anything,” they said.

“Show me a diagram of the US presidents since FDR, with their names and years in office under their photos,” I said.

08.08.2025 18:54 — 👍 3103    🔁 740    💬 333    📌 606
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Fintan O'Toole: Gaza is also a war on the human instinct for compassion When we learn to shut down pity, we summon the pitiless to power

irishtimes.com/opinion/2025/08/05/gaza-is-also-a-war-on-the-human-instinct-for-compassion/

05.08.2025 12:38 — 👍 30    🔁 11    💬 1    📌 2
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Original Sin by Kathryn Paige Harden: 9780593447628 | PenguinRandomHouse.com: Books An intellectually daring and deeply intimate exploration of how genetics complicates our ideas about blame, punishment and moral responsibility—from acclaimed psychologist and author of The Genetic....

I wrote another book & I'm very excited (& nervous) for it to be released into the world: www.penguinrandomhouse.com/books/714593...

03.08.2025 22:42 — 👍 91    🔁 27    💬 11    📌 9

@tjryan is following 19 prominent accounts