François Leulier

🧠Talk about having guts! 💪Embryonic mouse intestines stained for ❤️💚 nerves and 💙 endothelial cells, forming the early circuits that keep things moving (literally!) 🔬 Image by Nathan Burns. #FluorescenceFriday #DevBio

I'm looking to recruit a post-doc to help push forward our growing interests in insect ecotoxicology.
Apply here by Nov 30th!
(thanks for reposting)

career5.successfactors.eu/sfcareer/job...

Promoter-proximal gatekeepers restrict pleiotropic enhancer inputs to achieve tissue specificity Developmental enhancers are central regulatory elements that can activate multiple genes, yet how they selectively regulate one gene over its neighbours remains unclear. Using the Drosophila twist E3 ...

Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one?

Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...

q.e.d Science Critical Thinking AI for constructive criticism and science evaluation

Here's the link to the system, try it! qedscience.com
@qedscience.bsky.social

Reaffirming the value of model organisms in training scientific minds - Nature Cell Biology As biomedical research prioritizes human models and translational promise, classic model organisms are increasingly dismissed. Here we argue that they have a lasting value, both in enabling discovery and in cultivating scientific thinking, by training researchers in systems reasoning, integrative thinking and independent inquiry.

Model organisms, in particular non-mammalian model organisms, such as yeast, Caenorhabditis elegans, #Drosophila and zebrafish, have long stood at the centre of biological discovery www.nature.com/articles/s41...

So well deserved @ameliejoly.bsky.social
Congrats!!’

Congrats team!

Congratulations to first authors @ameliejoly.bsky.social and @lucasrebiffe.bsky.social for taking this project forward.
A big thanks to @frm-officiel.bsky.social and @agencerecherche.bsky.social for funding this work, and @igflyon.bsky.social for making the right environment for the research.

In normally growing juveniles, semaglutide improves glucose control without affecting growth.
But in stunted mice, it further impairs linear growth, revealing a key interplay between energy metabolism and the somatotropic axis during development.
Mechanistic, not clinical!

Our new study, just accepted in the Journal of the Endocrine Society
👉 doi.org/10.1210/jend...
We found that semaglutide, beyond its metabolic effects, can exacerbate growth stunting in juvenile mice by reducing energy metabolism, a context-dependent effect of GLP-1 signaling.

📢 Institut Jacques Monod Lecture

📅 October 17th
📍 IJM

Next week, Bruno Lemaitre, will present the Institut Jacques Monod lecture « A retrospective analysis of 400 publications reveals patterns of irreproducibility across an entire life sciences research field »

➡️ buff.ly/qqCVgL9

Amazing paper on how metabolites act as signaling factors which impact growth and development by ways which are not limited to merely changes in flux, energy production and biogenesis.
#Drosophila #metabolism #ecdysone #Ampk #interorgancommunication

This is our privilege to maintain our long lasting collaboration!

... and we had the pleasure of the live detailed explanation today @igflyon.bsky.social by Richard himself!
Tks for coming to our external seminar series.

A GPCR signaling pathway in insect odor detection Odor detection differs fundamentally in vertebrates, which use G protein-coupled receptors (GPCRs), and insects, which employ ion channels. Here, we report the first evidence for a GPCR defining tunin...

Having personally sworn for years that insects don’t use GPCRs for odour detection, Suguru Takagi (@sugurutakagi.bsky.social) discovers that, in fact, they sometimes do …

www.biorxiv.org/content/10.1...

#ExpertsCNRS 🔎 Journalistes, en lien avec le #NobelPrize de médecine, le bureau de presse du @cnrs.fr vous propose des scientifiques pouvant vous éclairer sur les travaux des lauréats.

Si vous êtes intéressés :
📞📩 cnrs.fr/fr/contacts

Nobel Prize in Physiology or Medicine 2025 The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

If you want to know more about the science behind the latest @nobelprize.bsky.social in Physiology and Medecine awarded to the "FoxP3-Tregs" field have a look at this:
www.nobelprize.org/prizes/medic...
A very detailed account!

Using gnotobiotic mice to decipher effects of gut microbiome repair in undernourished children on tuft and goblet cell function https://www.biorxiv.org/content/10.1101/2025.10.02.680046v1

Remote control of AMPK via extracellular adenosine controls tissue growth - Nature Cell Biology Zhang et al. demonstrate that AMPK can be activated by signalling metabolite, adenosine, under non-stress conditions during Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth.

💫NEW: @telemanlab.bsky.social & co demonstrate that #AMPK can be activated by signaling metabolite, #adenosine, under non-stress conditions during #Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth.
bit.ly/4gX6njF

#edrc2025 European #drosophila Society meeting announces the 2029 meeting location : see you all in Szeged (and Bonn in 2027 of course)!

Dear JEDIs,
as we are self-organizing using the #EDRC as a nucleator we decided it is time for a JEDI database to boost our network! If you identify as a JEDI, please contact us here or send a mail to katja.rust@uni-marburg.de to be added to our database.
#Drosophila
@fly-eds.bsky.social

The @fly-eds.bsky.social is having its general assembly this saturday at 13:30 at #EDRC2025 , please join us to discuss our society and to find out more about @flybase.bsky.social and the current funding crisis

Inorganic sulfate is critical for Mycobacterium tuberculosis lung tissue colonization and redox balance | PNAS Tuberculosis remains the deadliest infectious disease caused by a single pathogen, highlighting the urgent need for novel therapies. A deeper under...

Excited to share Wendy Le Mouëllic’s PhD work, now published in @pnas.org!
It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance.
Huge congrats to Wendy & colleagues!
shorturl.at/WbFQC

Only a few hours left before our meeting starts! Are you travelling to #EDRC2025 now? Let us know by using the oficial #EDRC2025 hashtag!

Fly PIs from @igflyon.bsky.social en route to #EDRC2025!
Starring @yghavi.bsky.social, Samir Merabet (incognito, not on Bluesky), and @enriquezlab.bsky.social - already conducting ‘field research’ on Alicante delicacies 😋

Pathogen-induced damage in Drosophila: Uncoupling disease tolerance from resistance
#Drosophila

a man with a beard blowing a horn with the letter x on his belt ALT: a man with a beard blowing a horn with the letter x on his belt

We are recruiting postdocs and PhD students! 🎓🔬

Check out the offer here 👉 igfl.ens-lyon.fr/equipes/j-en...

Please share, thanks! 🙏

Directors The Max Planck Society offers Directors a unique platform for groundbreaking research and leadership in diverse scientific fields.

Open Call for Expressions of Interest: become a Max Planck Director & redefine what’s possible in science! We offer scientific independence, long-term stable funding & exceptional infrastructure. Lead your own department & open new frontiers of research. Apply by 31 Oct 2025 → www.mpg.de/directors

📢Call for Junior Group Leader in Functional Genomics

The Institute of Biology of the École Normale Supérieure is seeking to recruit a junior group leader in the area of Functional Genomics.

Deadline: October 31st, 2025

#IBENS #joboffer

🔗 www.bio.ens.psl.eu/depbio/spip....

Tks to the awesome jury composed of @bardinlab.bsky.social
Ditte Andersen (sharing bluesky account with @colombani-lab.bsky.social)
@leopoldlab.bsky.social
@mollereaulab.bsky.social