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adam grieve

@adamgrieve.bsky.social

Membrane protein signalling and turnover in neurons Sir Henry Dale Fellow at School of Biochemistry, University of Bristol grieve-lab.com

1,039 Followers  |  555 Following  |  9 Posts  |  Joined: 20.12.2023  |  1.7077

Latest posts by adamgrieve.bsky.social on Bluesky

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Today in the journal Science: BioEmu from Microsoft Research AI for Science. This generative deep learning method emulates protein equilibrium ensembles – key for understanding protein function at scale. www.science.org/doi/10.1126/...

10.07.2025 18:10 β€” πŸ‘ 106    πŸ” 49    πŸ’¬ 1    πŸ“Œ 3
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Call for 20 Assistant Professor positions Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...

Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages.

ki.se/en/about-ki/...

25.06.2025 14:56 β€” πŸ‘ 263    πŸ” 263    πŸ’¬ 1    πŸ“Œ 14

This sounds like a fun job!

24.06.2025 08:03 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Grant Cancellation Web Form

WAS YOUR GRANT CANCELED BY PRESIDENT TRUMP?

The Committee on Science, Space, and Technology, Democratic Staff, is surveying the impact of the Trump Administration’s cancelation of federal research awards. If your award was terminated since January 20, 2025, please fill out this brief survey. If you had multiple awards terminated, please fill out a separate form for each award. While anonymous submissions will be helpful to the Committee’s efforts, we encourage you to leave your contact information if you are open to having a confidential conversation with Committee staff. Please find our confidentiality policies at the following link – any information you share will be treated with these protections, regardless of your current affiliation with any current or former funding agency: https://democrats-science.house.gov/contact/whistleblower

Grant Cancellation Web Form WAS YOUR GRANT CANCELED BY PRESIDENT TRUMP? The Committee on Science, Space, and Technology, Democratic Staff, is surveying the impact of the Trump Administration’s cancelation of federal research awards. If your award was terminated since January 20, 2025, please fill out this brief survey. If you had multiple awards terminated, please fill out a separate form for each award. While anonymous submissions will be helpful to the Committee’s efforts, we encourage you to leave your contact information if you are open to having a confidential conversation with Committee staff. Please find our confidentiality policies at the following link – any information you share will be treated with these protections, regardless of your current affiliation with any current or former funding agency: https://democrats-science.house.gov/contact/whistleblower

Are you a PI of a federal grant cancelled by the Trump administration?

Please share your info with the Democratic Staff of the House Committee on Science, Space, and Technology, who launched this portal yesterday to track funding cancellations πŸ”­πŸ§ͺ

forms.office.com/pages/respon...

29.05.2025 13:46 β€” πŸ‘ 317    πŸ” 289    πŸ’¬ 4    πŸ“Œ 8

Industry friends, now is the time for MUCH more speaking out on behalf of academic colleagues under duress. Here are core open source methods that many of your products doubtlessly depend on either directly or indirectly (see en.wikipedia.org/wiki/HMMER) being abruptly defunded. Make noise.

29.05.2025 14:39 β€” πŸ‘ 76    πŸ” 50    πŸ’¬ 1    πŸ“Œ 0
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πŸ”¬ Hiring: Postdoctoral Fellow

Seeking a bioinformatician/screening expert to be part of our team running genome‑wide screens, building data‑integration pipelines & validating hits in higher organisms.

🌱 2‑yr fellowship with tailored mentorship, leadership & science‑communication training

18.04.2025 08:03 β€” πŸ‘ 8    πŸ” 7    πŸ’¬ 1    πŸ“Œ 2

Come and join us in solving mystery of plasma membrane proteostasis in beautiful neurons.

10.04.2025 13:14 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Pls re-skeet! There's a postdoc job available to join us in Bristol! We're looking for a molecular cell biologist to help us investigate plasma membrane proteostasis in neurons. Apply here by 23 April: www.jobs.ac.uk/job/DMO097/r.... If interested, do contact me and check out grieve-lab.com! Thanks!

09.04.2025 15:42 β€” πŸ‘ 9    πŸ” 15    πŸ’¬ 1    πŸ“Œ 3
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Announcing the JCS–David Stephens Prize and the 2024 winner Anja Konietzny Over the past 25 years, Journal of Cell Science (JCS) has been awarding a prize of Β£1000 – β€˜The JCS Prize’ – to the first author(s) of the paper that is judged by the Editors to be the best paper publ...

A fitting announcement to an outstanding scientist and friend who is dearly missed by many. journals.biologists.com/jcs/article/...

07.04.2025 13:29 β€” πŸ‘ 23    πŸ” 6    πŸ’¬ 1    πŸ“Œ 1
Protein structure of C1 bound to IgM antibodies

Protein structure of C1 bound to IgM antibodies

Our new lab website is online!

sharplab.uk

Check it out and learn more about our research in Bristol!

09.04.2025 08:36 β€” πŸ‘ 17    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0
Research Assistant - Godlee Group (Fixed Term) - Job Opportunities - University of Cambridge Research Assistant - Godlee Group (Fixed Term) in the Department of Biochemistry at the University of Cambridge.

I am recruiting a research assistant. Please send to anyone you know who is interested in gaining more lab experience in host:pathogen interactions of bacterial infections.

www.jobs.cam.ac.uk/job/50738/

31.03.2025 07:38 β€” πŸ‘ 12    πŸ” 16    πŸ’¬ 0    πŸ“Œ 0
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Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...

SO excited to share that a major part of the postdoctoral work in @robzonculab.bsky.social lab is now published: β€œLeucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins” www.science.org/doi/10.1126/...

27.03.2025 19:45 β€” πŸ‘ 84    πŸ” 30    πŸ’¬ 7    πŸ“Œ 4
Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization

Check out our new paper with Michael Landreh, @pstansfeld.bsky.social and others in @elife.bsky.social : Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization doi.org/10.7554/eLif...

27.03.2025 09:31 β€” πŸ‘ 14    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0

Applications close today for this @uniofmanchester.bsky.social #DigitalNotebook #Metascience project, seasoned with #OpenResearch & served with helpings of #ResearchIntegrity and a side of #ResearchCulture

Full details of everything on the menu below πŸ‘‡

www.jobs.manchester.ac.uk/Job/JobDetai...

24.03.2025 13:12 β€” πŸ‘ 0    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Thank you Ines! I had such a lovely time visiting sunny York this week, sharing our science and chatting cell bio, neuroscience and proteases. Thanks for the invite, special thanks to the one and only @yorkyeast.bsky.social for top-notch hosting!

23.03.2025 12:04 β€” πŸ‘ 7    πŸ” 1    πŸ’¬ 0    πŸ“Œ 1
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Toward single-molecule protein sequencing using nanopores Nature Biotechnology - Maglia and colleagues discuss advances in nanopore technology en route to single-molecule protein sequencing

Nanopore technology might be able to sequence proteins soon! Read about the road ahead in this exciting Perspective rdcu.be/edWPi in @naturebiotech.bsky.social

18.03.2025 10:18 β€” πŸ‘ 88    πŸ” 33    πŸ’¬ 2    πŸ“Œ 1
An image montage advertising NeuroBioUK - 12th of September 2025 in York. The image is York cathedral superimposed over a fluorescent cortex mouse section coloured to look a bit like a dawn sky.

An image montage advertising NeuroBioUK - 12th of September 2025 in York. The image is York cathedral superimposed over a fluorescent cortex mouse section coloured to look a bit like a dawn sky.

Do you need some science joy in your life? Do you like neurons? Maybe glia? Molecules? Cell biology? Save the date for #NeuroBioUK25 - the venue is booked and we are excited to see you and your incredible science there on the 12th of September!

neurobiouk.sites.sheffield.ac.uk

06.03.2025 07:57 β€” πŸ‘ 29    πŸ” 14    πŸ’¬ 1    πŸ“Œ 2
An image montage advertising NeuroBioUK - 12th of September 2025 in York. The image is York cathedral superimposed over a fluorescent cortex mouse section coloured to look a bit like a dawn sky.

An image montage advertising NeuroBioUK - 12th of September 2025 in York. The image is York cathedral superimposed over a fluorescent cortex mouse section coloured to look a bit like a dawn sky.

Save the date: We're excited that the third NeuroBioUK will take place on September. Block it in your calendar to join us in York for a fun day of neurons, glia, cool science and chats!

06.03.2025 09:23 β€” πŸ‘ 5    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Macrophages promote collagen deposition through circadian regulation of fibroblasts Collagen deposition in fibroblasts, the primary collagen-producing cells, is regulated by both macrophages and the circadian rhythm, although how these regulatory processes interact with one another i...

Our lab's #1st manuscript from our #1st #PhD Katie is on #bioRxiv! Check it out πŸ‘‡πŸ»

#macrophage regulation of fibroblast #collagen #circadian rhythm. #ImmunoECMatrix w/ @profandrewmac.bsky.social @tracyh9494.bsky.social @mcrcellmatrix.bsky.social @mcf-uom.bsky.social

www.biorxiv.org/content/10.1...

05.03.2025 08:28 β€” πŸ‘ 52    πŸ” 18    πŸ’¬ 0    πŸ“Œ 1

Exciting opportunity in the newly minted McMillan lab in Liverpool. Kirsty is a great scientist and a top mentor for students - if you’re looking for a PhD and are interested in trafficking and neurodegeneration, do contact her!

18.12.2024 18:29 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Thanks Loges, very kind of you!

10.12.2024 11:53 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
UK Membrane Trafficking Meeting 2024 | King's College London eStore Registration for the 2024 UK Membrane Trafficking Meeting, held at KCL.  Registration per person, to include sandwich lunch and coffee breaks and even

UK Membrane Trafficking 2024

Who doesn’t like a deadline that gets brought forward?

Please register by 3rd December - King’s need longer to make the sandwiches than I previously thought!

estore.kcl.ac.uk/conferences-...

Programme coming soon!

25.11.2024 08:53 β€” πŸ‘ 21    πŸ” 17    πŸ’¬ 0    πŸ“Œ 2

Amazing PhD opportunity to join an exciting new lab at Bristol Biochemistry - send your best students in Ferdos’ direction!

27.11.2024 12:36 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
This scheme shows the cargo adaptor FHF in the middle with arrows pointing to distinct microtubule and actin-based motors (dynein-dynactin, KIFC1, KIF1C and myosins V, IX and X as well as Tropomyosin 1). It also shows a link to Rab5 marked early endosomes. The hypothesis is that FHF coordinates multi motor binding at the early stages of endocytosis. The PhD project would address the hierarchy of motor binding and how these motors coordinate to allow the newly formed vesicle to transition from the actin to MT cytoskeletal network.

This scheme shows the cargo adaptor FHF in the middle with arrows pointing to distinct microtubule and actin-based motors (dynein-dynactin, KIFC1, KIF1C and myosins V, IX and X as well as Tropomyosin 1). It also shows a link to Rab5 marked early endosomes. The hypothesis is that FHF coordinates multi motor binding at the early stages of endocytosis. The PhD project would address the hierarchy of motor binding and how these motors coordinate to allow the newly formed vesicle to transition from the actin to MT cytoskeletal network.

If you’re interested in how molecular motors coordinate to power intracellular trafficking events (e.g. endocytosis), I’ve got a PhD position available to study this at vibrant Bristol uni. In this project, we will capture highly dynamic events by #cryoEM, single molecule imaging & cell biology. πŸ”¬β„οΈπŸ§ͺ

27.11.2024 12:15 β€” πŸ‘ 53    πŸ” 30    πŸ’¬ 1    πŸ“Œ 7
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Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c

15.11.2024 17:55 β€” πŸ‘ 72    πŸ” 81    πŸ’¬ 1    πŸ“Œ 4

Waves of new BlueSky arrivals in last few days!

I’ve been tracking starter packs relevant to molecular/mechanistic/genetic/cellular…etc biology

Hope it’s helpful but warning: now a v long thread!

Probably the last time I can do this...

12.11.2024 15:03 β€” πŸ‘ 194    πŸ” 115    πŸ’¬ 16    πŸ“Œ 19
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Interested in:
- mitochondrial regulation and quality control related to Parkinson's Disease?
- novel hemi-channels for mitochondrial protein import/degradation?
- the structural basis of PINK1 recognition by PARL?
Then read this cool paper from the Collinson and Corey labs! tinyurl.com/2hhp5h35

08.11.2024 09:45 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Want to work on a 4-year BBSRC-funded project to tag all Drosophila transcription factors with an exchangeable epitope? This is a 0.5 FTE Research Technician post. Come join our collaborative team and help cloning constructs, injecting fly eggs, and screening for transgenics. tinyurl.com/44mprcev

21.12.2023 17:51 β€” πŸ‘ 1    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0

Thanks Matthew - nice to be here!

20.12.2023 17:32 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

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