Xiaohan Li

Language models cannot reliably distinguish belief from knowledge and fact - Nature Machine Intelligence Suzgun et al. find that current large language models cannot reliably distinguish between belief, knowledge and fact, raising concerns for their use in healthcare, law and journalism, where such disti...

Language models cannot reliably distinguish belief from knowledge and fact #AI

Failure to make such distinctions can mislead diagnoses, distort judicial judgments and amplify misinformation.

www.nature.com/articles/s42...

Electrostatic changes enabled the diversification of an exocyst subunit via protein complex escape - Nature Plants The evolutionary diversification of an exocyst subunit was enabled by electrostatic shifts leading to its dissociation from the ancestral complex.

If you’re into protein evolution, molecular innovation, or just good scientific detective work — we hope you enjoy reading this story as much as we loved uncovering it.

Link: www.nature.com/articles/s41...

Happy Halloween 👻🌿

We (@sobuelow.bsky.social) developed AF-CALVADOS to integrate AlphaFold and CALVADOS to simulate flexible multidomain proteins at scale

See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs

📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...

If you are interested in membrane trafficking and IDPRs, please join us!

Best practices & tools in R & Python for statistical processing and visualization of #Lipidomics & #Metabolomics data

Data imputation/normalization
Batch correction
Data visualization
Statistical models

Instrumental handbook, adoptable for other omics

#NatComms 2025
www.nature.com/articles/s41...

2026 Intrinsically Disordered Proteins Conference GRC The 2026 Gordon Research Conference on Intrinsically Disordered Proteins will be held in Les Diablerets, Vaud (fr) Switzerland. Apply today to reserve your spot.

🚨🚨The GRC on Intrinsically Disordered Proteins #IDPs is back!! 🍝🧵🏔️Join us for cutting-edge IDP science, great discussions, and mountain views 🌄🍝
📅 June 21-26, 2026 | Les Diablerets, Switzerland
👉 Details & registration: grc.org/intrinsicall...

Why are transcription factors disordered? Come join us in Oxford as a postdoc and we'll find out together!

Help publish 3 mature projects, AND develop cool new single molecule fluorescence binding assays!

biophysics
transcription
protein:DNA interactions

my.corehr.com/pls/uoxrecru...

Amazing! A lot of congrats Alex!

Snapshot of a condensate near a lipid membrane with Swedish Research Council and Malmö University logos.

I'm hiring for a PhD position at Malmö University, Sweden!

The project will focus on molecular modelling of proteins, lipids, and biomolecular condensates at cell membranes.

More details and application form: tinyurl.com/4zm92365

Please feel free to share!

@vetenskapsradet.bsky.social | @mau.se

The final version of our multispectral microscopy manuscript is now online at Nature Photonics: www.nature.com/articles/s41...

The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.

Is it just my feeling that the Bluesky community has suddenly grown dynamic and “real” (i.e, much less boring political statements to dilute interesting people and stuff on my timeline) in the past 3 months… oh Yay!

I wish 7-11 can come to the UK as well. So tired of “meal deals” when you don’t have time to cook… I mean, it is indeed a deal, but not really a meal…

hey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!

This isn't how birding is supposed to work!

Phyling: phylogenetic inference from annotated genomes Phyling is a fast, scalable, and user-friendly tool supporting phylogenomic reconstruction of species phylogenies directly from protein-encoded genomic data. It identifies orthologous genes by searchi...

New #preprint from talented graduate student for a workflow we have been using for a while into a formal usage www.biorxiv.org/content/10.1...

A picture of 3 rows of people on steps at the MRC LMB. From left to right - top row: Akaash, Vic, Lara - Middle row: Kerrie, Manu, Paddy - bottom row: Meg and Julie

🚨 JOB ALERT 🚨
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...

#STEMCareers #ResearchJobs

HxC Survey on Interdisciplinary Work Online surveys is a powerful, easy to use tool for creating online surveys. Run by Jisc, online surveys is used by over 300 different organisations in the UK...

🚨Interdisciplinary perspectives needed🚨
Have you worked across disciplines in research? We want to hear from you!
Take part in the Healthier Science through Collaboration (HxC) survey. Help shape better, more inclusive research environments.
app.onlinesurveys.jisc.ac.uk/s/edinburgh/...
Please RT.

Rachel Thomas, PhD - Deep learning gets the glory, deep fact checking gets ignored an AI researcher going back to school for immunology

"a fascinating case study on the limits of AI in biology and the harms of current publishing incentives" rachel.fast.ai/posts/2025-0...

Join us for the first Scottish Cell Biology Meeting in Dundee! 🔥

Free registration and lots of opportunities for oral, poster presentations, and networking opportunities! #SCBM2025

Abstract submission until June 6th, general registration until July. All cell biologists are welcome!

Chemists recreate how RNA might have reproduced for first time Chemists at UCL and the MRC Laboratory of Molecular Biology have demonstrated how RNA (ribonucleic acid) might have replicated itself on early Earth – a key process in the origin of life.

How did life on Earth begin? 🌍🧬
New #LMBResearch from Phil Holliger’s group, including James Attwater (now @uclchemistry.bsky.social‬‬ @uclnews.bsky.social) shows how pH-freeze-thaw cycles enables RNA self-replication, overcoming a key evolutionary hurdle.‬
Read more: www.ucl.ac.uk/news/2025/ma...

Really great to see this out!

"De novo prediction of protein structural dynamics"

I'll be presenting an overview of the field tomorrow at a workshop. Link to a PDF copy of the presentation: delalamo.xyz/assets/post_...

AlphaFold is amazing but gives you static structures 🧊

In a fantastic teamwork, @mcagiada.bsky.social and @emilthomasen.bsky.social developed AF2χ to generate conformational ensembles representing side-chain dynamics using AF2 💃

Code: github.com/KULL-Centre/...
Colab: github.com/matteo-cagia...

Pleased to see Kevin's paper on the Retromer complex interaction with yeast Vps5 and Vps17 proteins now online!

Remembering David Stephens (1971–2024) In the autumn of 2024, David Stephens, a prominent member of the UK cell biology community and a brilliant scientist, leader and mentor, passed away. With his pragmatism and natural authority, combine...

A great tribute to David Stevens, a terrific cell biologist and missed by so many of his friends and colleagues. As they say 'one of the good guys'. journals.biologists.com/jcs/article/...

Long-term studies provide unique insights into evolution

Long-term studies provide unique insights into evolution 🧪
www.nature.com/articles/s41...

Showcasing groundbreaking discoveries of long-term evolutionary studies underscoring their crucial role in advancing our understanding of the complex nature of evolution across multiple systems and timescales.

Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway Nature Reviews Molecular Cell Biology - Coat protein complex II (COPII) subunits assemble to form membrane transport carriers at ER exit sites, thereby concentrating secretory cargoes and...

I am thrilled to announce my and @giuliazanetti.bsky.social's latest review "Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway" in @natrevmcb.bsky.social with @springernature.com.

Check it out here!
rdcu.be/eeY1J

#COPII #CryoEM #TeamTomo #MembraneTrafficking #ERES

biorxiv.org/content/10.1... Here’s a paper that was many years in the making. The idea that the climate can affect the thermodynamic mechanism of binding due to the temperature dependence of the entropy term is interesting- we see gradual shift in binding mode along evo trajectory…

Attending #biologists100 in Liverpool and just finished the ECR session — really inspiring career keynote talk and invaluable experience talking to established figures in all fields related to biology for advice! Greatly enjoyed it!