Gill Wilson

Anti-progestin therapy targets hallmarks of breast cancer risk Nature - Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing...

Really happy to share a link to our work showing that anti-progestin therapy could help prevent breast cancer before menopause.
Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts: urldefense.com/v3/__https:/...
Brilliant team science

Chemokine receptor expression defines a trajectory from monocytes to mature macrophages CCR1, CCR2 and CCR5 direct recruitment of monocytes and macrophages in inflammation. However, the discrete role for each receptor in monocyte/macrophage biology remains poorly understood, with previou...

Our CRG newest preprint! Please read and share 😀
www.biorxiv.org/content/10.1...

Delighted to contribute to this project! Please read and repost 😊

Lily's last day 🥲 @crgglasgow.bsky.social Thesis hand in next week

#EMDS2025 attendees - if anyone is looking for a postdoc position and likes what they see of #Edinburgh, please come and speak to me or @lizihegarty.bsky.social (poster 71) or @erinwatson.bsky.social (poster 35).

Almost a 3 h drive from Glasgow to Edinburgh but we're here. Train tomorrow 😂 Ready for @emds2025.bsky.social

Not all chemokine signaling is about cell migration!

In mouse erythroblasts, CXCL12-bound CXCR4 enters the nucleus to control gene transcription, trigger calcium bursts, and drive red blood cell formation—especially enucleation.

🔗 science.org/doi/10.1126/sc…
#chemokine #CXCR4

Inflammatory chemokine receptors CCR1, CCR2, CCR3 and CCR5 are essential for an optimal T cell response to influenza, in this work from @mariekedoesscience.bsky.social and colleagues at @crgglasgow.bsky.social:
www.mucosalimmunology.org/article/S193...

Brilliant time as always at our @crgglasgow.bsky.social away day at @sceneuog.bsky.social

Vaccination against helminth IL-33 modulators permits immune-mediated parasite ejection The murine intestinal nematode Heligmosomoides polygyrus bakeri (Hpb) modulates the host immune response via the Hpb alarmin release inhibitor (HpARI)…

🚨 New McSorley lab paper just out in Cell Reports!

Very happy to see this published - it has been a lot of work, and its turned into a really nice story.

In it, we show that HpARI+HpBARI can be used as vaccines

Tutorial thread below (1/16):

www.sciencedirect.com/science/arti...

So excited to share our first neuro focused paper from the lab, we show that CXCL4 (PF4) is transported into the brain by proteoglycans within the endothelial glycocalyx and that GAG binding also mediates the pro neurogenesis effects of CXCL4. www.biorxiv.org/content/10.1...

The tetanus vaccine has saved an astonishing 27.9 million lives - roughly equivalent to the entire population of Australia 🦘 bit.ly/4ig1KAm

Read more about the success of the tetanus vaccine in our latest #CelebrateVaccines blog!

🔗 bit.ly/42CgrZN

With decorative wheeliebins 😄

Sun's out 😎 In case anyone is in need of a dog picture in their feed 🐶💕 #DogsOfBluesky

Inflammatory chemokine receptors CCR1, CCR2, CCR3 and CCR5 are essential for an optimal T cell response to influenza. Inflammatory chemokine receptors CCR1/2/3/5 (iCCRs) play an important role in the recruitment of immune cells involved in innate immune functions and orchestrating the adaptive immune response. Here w...

Some nice new reserach from @mariekedoesscience.bsky.social and @crgglasgow.bsky.social studying the inflammatory CCR locus and immune responses to influenza. www.biorxiv.org/content/10.1...

Lab’s latest: (mouse) mums grow their guts during pregnancy and lactation: www.cell.com/cell/fulltex...

Screen shot of a Google search confirming that the 2025 Spring equinox falls on 20th March at 9:01.

How about a tiny touch of good-fulness to counter the awfulness.

By both astronomical and meteorological measures, at 9:01 today it will be officially Spring.
🪻

Finally pulled the deactivate button on twitter 💀 Will miss #ScienceTwitter but very glad mostly everyone is here 😃

Challenge accepted 😂 Love this

The man with the golden arm A short tale of immunology and one man's incredible commitment.

A little immunology story celebrating the legacy of James Harrison- something positive in amongst the gloom 🧪

Macrophages promote collagen deposition through circadian regulation of fibroblasts Collagen deposition in fibroblasts, the primary collagen-producing cells, is regulated by both macrophages and the circadian rhythm, although how these regulatory processes interact with one another i...

Our lab's #1st manuscript from our #1st #PhD Katie is on #bioRxiv! Check it out 👇🏻

#macrophage regulation of fibroblast #collagen #circadian rhythm. #ImmunoECMatrix w/ @profandrewmac.bsky.social @tracyh9494.bsky.social @mcrcellmatrix.bsky.social @mcf-uom.bsky.social

www.biorxiv.org/content/10.1...

Poster day! Please come and chat later at poster 2036 #ksmyeloid25

Lunchtime view 😎 #ksmyeloid25

We're based in the Ashworth Laboratories, King's Buildings, University of Edinburgh. Photo shows the main staircase in the entrance to the Ashworth, stone steps from the 1920s, decorated with a series of bright, colurful banners depicting the science that's tackled in the building.

I'm very pleased to have two lab positions open this week, to join our team looking at immune regulation in infection and co-infection. We're especially interested in tissue-based immunity, cytokine regulation and immune metabolism. Join us! Postdoc (3y) and research technician (12mo) posts open.

Hallo Hannover! Ready for the #KSmyeloid25 @keystonesymposia.bsky.social tomorrow👩‍🔬

🌺 My Happy Sunday Post!⁣

This past Tuesday, we celebrated the 🧪𝐈𝐧𝐭𝐞𝐫𝐧𝐚𝐭𝐢𝐨𝐧𝐚𝐥 𝐃𝐚𝐲 𝐨𝐟 𝐖𝐨𝐦𝐞𝐧 𝐚𝐧𝐝 𝐆𝐢𝐫𝐥𝐬 𝐢𝐧 𝐒𝐜𝐢𝐞𝐧𝐜𝐞 🧬🌸. In these onerous and uncertain times for both #science and #women, let’s hold on to a bit of #optimism!

#WomenInScience
#WomenInSTEM #Diversity
#Education #Equity #Inclusion

Despite the current uncertainty of being a scientist, I am excited to share our manuscript demonstrating an interesting mechanism of how swirling motion of breast cancer cells align collagen fibers radially at the tumor-stroma interface to enable their invasion (1/11) @thechaudhurilab.bsky.social

#hiring #postdoc
We are looking for a postdoc to work on anti-tumor gamma delta T cells in breast cancer metastasis mouse models. Apply here:
www.gla.ac.uk/explore/jobs...

🍬Our 2024 update🍬 on monocytes their origins and development - with @kim-lab.bsky.social and Alex Mildner - The image below uses a 'sweet shop analogy' to illustrate the plasticity of monocytes during the immune response 🍬 artist Maya Rachman doi.org/10.1093/disc...