Enrica Boda & team

The regenerative potential of adult Nestin+ cerebellar astroglia is limited compared to in neonates There is a crucial need for strategies that stimulate repair in the adult brain. The neonatal mouse cerebellum can regenerate via the adaptive reprogramming of nestin (Nes)-expressing progenitors (NEP...

Excited to share the final piece of my postdoctoral work from the Joyner Lab, exploring the regenerative potential of the adult cerebellar astroglia in collaboration with @ricardkoche. 🧠

www.biorxiv.org/content/10.6...

A brief guide to statistical analysis of grouped data in preclinical research - Nature Metabolism Clustering and nesting (C&N) arise in many preclinical studies, such as when animals are group-housed or share litters, or in cell culture. Ignoring C&N undermines the validity of analyses. Here, we explain how C&N arise, as well as valid designs and analyses.

#Throwback 🧪

COMMENT | A brief guide to statistical analysis of grouped data in preclinical research

@colbyvorland.bsky.social
L Golzarri-Arroyo
DB Allison

Astrocyte senescence impairs synaptogenesis due to Thrombospondin-1 loss. https://www.biorxiv.org/content/10.64898/2025.12.02.691780v1

Fus depleted oligodendrocytes reduce neuronal damage and attenuate AD progression in the AppNL-G-F mouse https://www.biorxiv.org/content/10.1101/2025.11.24.689041v1

WWOX deficiency uncovers a cell-autonomous mechanism impairing myelin repair https://www.biorxiv.org/content/10.1101/2025.11.22.689900v1

APOE E4 Alzheimer's Risk Converges on an Oligodendrocyte Subtype in the Human Entorhinal Cortex https://www.biorxiv.org/content/10.1101/2025.11.20.689483v1

Developmental Dynamics <em>Developmental Dynamics</em> is a developmental biology journal publishing novel discoveries that advance our understanding in development, morphology, evolution, and disease.

Dear #Neuroscience researchers, I am Guest Editing an issue in @devdynamics.bsky.social on NEURAL MIGRATION.
Due date: March 31, 2026.

Great opportunity to showcase your findings on neural migration. #DevBio

Please reskeet 🙏

anatomypubs.onlinelibrary.wiley.com/journal/1097...

CNS Myelin Sheath Lengths Locally Scale to Axon Diameter via Piezo1 https://www.biorxiv.org/content/10.1101/2025.11.18.689045v1

White matter degeneration precedes tau aggregation in rats with Alzheimer's-like tauopathy Tau pathology is increasingly recognized as a primary driver of white matter (WM) microstructural damage in tauopathies, particularly in Alzheimer's d…

White matter degeneration precedes tau aggregation in rats with Alzheimer's-like tauopathy

www.sciencedirect.com/science/arti...

Neuronal activity promotes repair by microglial reprogramming following demyelination https://www.biorxiv.org/content/10.1101/2025.11.19.689194v1

The transcription factor BCL11A restores differentiation potential to aged oligodendrocyte progenitor cells https://www.biorxiv.org/content/10.1101/2025.11.19.689239v1

Mislocalisation of TDP-43 to the cytoplasm of either neurons or oligodendrocytes causes axonopathy and dysmyelination https://www.biorxiv.org/content/10.1101/2025.11.17.688801v1

Obituary: Jose Manuel García‐Verdugo (1954–2025), an Exceptional Eye Into the Fine Structure of the Brain's Germinal Centers Click on the article title to read more.

Obituary: Jose Manuel García-Verdugo (1954–2025), an Exceptional Eye Into the Fine Structure of the Brain's Germinal Centers

Arantxa Cebrian-Silla, Mercedes Paredes, Arturo Alvarez-Buylla

onlinelibrary.wiley.com/doi/10.1002/...

Astrocytic FABP5 drives non-cell-autonomous oligodendrocyte injury in multiple system atrophy by promoting TNF signaling and ferroptotic stress https://www.biorxiv.org/content/10.1101/2025.11.08.687320v1

Microglia-Derived Extracellular Vesicles Enhance Oligodendrocyte Maturation by Transcriptionally Regulating Mitochondrial Molecular Pathways - Cellular and Molecular Neurobiology Degeneration of myelinating oligodendrocytes and the resulting breakdown of the myelin sheath are key drivers of neurodegeneration and disability across numerous central nervous system pathologies. Thus, a compelling strategy to preserve neuronal function is to promote endogenous myelin repair by oligodendrocyte precursor cells (OPCs). Extracellular vesicles (EVs) secreted by pro-regenerative microglia have been shown to enhance OPC maturation and remyelination across different experimental m...

🔬 Research Spotlight
#Microglia-derived extracellular vesicles promote OPC differentiation by rewiring mitochondrial metabolism — revealing new therapeutic targets for demyelinating & neurodegenerative diseases.
👉 https://link.springer.com/article/10.1007/s10571-025-01612-7

Spatial dynamics of brain development and neuroinflammation - Nature A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.

Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com

www.nature.com/articles/s41...

Beautiful and useful study by @cheadlelab.bsky.social

Oligodendrocytes support functional development of subcortical premotor neurons and navigation https://www.biorxiv.org/content/10.1101/2025.11.01.686017v1

Vertigine, una mappa per capire (e fidarsi) della scienza Aspettarsi che una persona rimanga razionale quando è spaventata e confusa non è - appunto - per nulla razionale. Ed è in quei momenti che il rischio di cadere in un baratro di farmaci miracolosi e cu...

Nel suo nuovo libro “Vertigine. Storie di chi si affida alla scienza e di chi impara a farlo”, Beatrice Mautino racconta cosa succede quando la paura incrina la fiducia nella razionalità e ci spinge verso cure miracolose e scorciatoie pseudoscientifiche

www.scienzainrete.it/articolo/ver...

This is figure 4, which shows protein–protein network analysis reveals protein networks involved in pwMS.

Myelin damage in multiple sclerosis can be detected up to seven years before symptoms, with early immune pathway activation and a 21-protein panel showing promise for presymptomatic diagnosis, according to a paper in Nature Medicine. go.nature.com/4qqq47L #medsky 🧪

OASIS: in vivo AAV-mediated transduction and genome editing of adult oligodendrocytes https://www.biorxiv.org/content/10.1101/2025.10.20.683551v1

Microglial plasticity across development mediates infantile amnesia https://www.biorxiv.org/content/10.1101/2025.10.17.683060v1

Early developmental neuronal activity inhibits oligodendrocyte differentiation through AMPA receptor activation https://www.biorxiv.org/content/10.1101/2025.10.17.683139v1

Developmental CA2 perineuronal net reduction restores social memory in Shank3B KO mice https://www.biorxiv.org/content/10.1101/2025.10.12.681906v1

a must read for anyone interested visual cortex plasticity - a fresh look at some textbook models and a fun read. congratulations to the authors!

The Woman of a Thousand Brains: Augusta Déjerine-Klumpke, Pioneer Neuroscientist. The brain is ready. It luxuriated in a solution of potassium bicarbonate for a year, and then in a thick mixture of nitrocellulose for another month and a half, and now it is finally ripe for the slic...

Neuroscience legend Augusta Déjerine-Klumpke was born 166 years ago today. She discovered Klumpke's Palsy in 1885, and was co-author of the definitive 1200 page Sémiologie du Système Nerveux and the 2-volume Anatomie des Centres Nerveux.

tinyurl.com/bdfb4tbh

#WomenInSTEM #Neuroscience #NeuroSky 🧠🧪

Integrated omics reveals disease-associated radial glia-like cells with epigenetically dysregulated interferon response in multiple sclerosis Park, Nicaise, Tsitsipatis, and colleagues discover transcriptional and epigenetic markers in human PMS iNSCs and fibroblasts that may underlie their senescent and inflammatory state. Novel DARGs with...

Delighted to see this out in @NeuroCellPress!!!

Together with Isabel Beerman (& many other friends) we identify disease-associated radial glia-like cells (#DARGs) that fuel #inflammation and #neurodegeneration in #progressiveMS

www.cell.com/neuron/fullt...

Spatial lipidomics reveals demyelination and remyelination dynamics in the mouse brain Myelin pathology in demyelinating diseases is accompanied by lipid remodeling that remains challenging to characterize at spatial level using traditio…

Remyelinated fibers have a distinct lipid profile compared to intact myelin
www.sciencedirect.com/science/arti...

Myelin pathology is a key feature of X-linked Dystonia Parkinsonism https://www.biorxiv.org/content/10.1101/2025.10.07.680990v1

GlialCAM Cytoplasmic Signaling in Oligodendrocytes and Astrocytes is Essential for White Matter Homeostasis in the Brain https://www.biorxiv.org/content/10.1101/2025.10.03.680331v1