Wiltgenlab

Yes. And when you're later in your career, you will never agree to do a talk at 8am 😂

How prediction error drives memory updating: role of locus coeruleus–hippocampal interactions The brain constantly generates predictions based on one’s knowledge of the world, as captured in memory. When these predictions are in error, our knowledge base must be revised to remain relevant. Her...

How prediction error drives memory updating: role of locus coeruleus–hippocampal interactions: Trends in Neurosciences www.cell.com/trends/neuro...

New paper from the lab led by Ali Golbabaei. If you’re interested in systems consolidation, generalization and hippocampal neurogenesis a short 🧵 follows:

authors.elsevier.com/a/1lsO73QW8S...

So proud🤩: Beautiful work by @clykken.bsky.social 💃🏻 et al: finally we understand how the hippocampus can express multiple maps even though grid cell inputs are universal metrics.
E.g. hippocampal global remapping was induced when different grid modules anchored independently to environments. See 👇🏽

AI Overview: "Dental realism"refers to the philosophical debate about whether teeth exist independently of human perception, a concept rooted in metaphysical realism. While realism asserts an objective reality for teeth, idealist philosophies contend that teeth's existence is tied to our consciousness and perception. Philosophers use this idea, for example, to discuss the ethics of tooth extraction, examining whether a procedure impacts a real entity or merely a subjective experience.

When a typo in your Google search leads to new and exciting philosophical positions

Thrilled to share that our work is now published in Science! ✨

We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! 🧭

www.science.org/doi/10.1126/...

🧵1/

MLK Jr. on violence:

Mice are always smarter that we expect, here guessing the trail ahead rather than just blind following. Cool work:

When the PI hasn't worked in at the bench in years but needs to do something in the lab for a photoshoot

Terrible

Green Day at Bottlerock 2025 🤘

Prefrontal encoding of an internal model for emotional inference Nature - Neurons in the rodent dorsomedial prefrontal cortex encode a flexible internal model of emotion by linking directly experienced and inferred associations with aversive experiences.

I’m excited to share a new paper from the lab. The study led by Xiaowei Gu reveals how the mPFC encodes complex emotional memories, using an internal model to infer emotional associations and memories via projections to the amygdala. a🧵(1/8)

rdcu.be/el19t

Systems consolidation reorganizes hippocampal engram circuitry Nature - A study shows that loss of memory precision associated with systems consolidation can be explained by neurogenesis-dependent reorganization of engram circuitry within the hippocampus over...

Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation.

rdcu.be/el18q

A short thread follows for those interested.

1/n

Congrats!!!

Terrible

Heterogeneous pericoerulear neurons tune arousal and exploratory behaviours - Nature A set of neurons in the peri-locus coeruleus region controls arousal and avoidance states, providing an understanding of the neurobiological basis of arousal and exploratory behaviours.

A wonderful day for science, to see the (peri) #LC in all its glory. A ginormous effort from all involved, and a fantastic resource for the field. Chapeau 🎩

🧠 🔵

www.nature.com/articles/s41...

Said goodbye to Ana and Cassiano last night. Best of luck in Brazil!!!

YouTube video by Steve Lawson Kara Marshall PHD-History of Science in America - Trilogy at Tehaleh 04/27/25

Gave a talk at my parents’ retirement community to describe how science is done, and what is at stake. There was a ton of interest, and anyone can do this. Get the word out about how science affects everyone. I’m happy to share slides with anyone who asks- just get in touch! youtu.be/BY_SFgi-Cig

Check out our latest paper today in Nature: “Goal specific hippocampal inhibition gates learning” www.nature.com/articles/s41...
By Nuri Jeong, Xiao Zheng, Abby Paulson, Steph Prince and colleagues.

On the responsibilities of intellectuals and the rise of bullshit jobs in universities You may never have considered yourself to be one. Why would you? But if you’re reading this, there is more than a likelihood that you are one. If you’re a

academic.oup.com/brain/articl...

Closed-loop modulation of remote hippocampal representations with neurofeedback Animal models of memory retrieval trigger retrieval with cues and measure retrieval using behavior. Coulter et al. developed a neurofeedback paradigm that rewards hippocampal activity patterns associa...

www.cell.com/neuron/fullt...

Ugh! Sorry to hear that

It's the post-"standard model" age! Our Preview of a fantastic new study from Yi Zhong's lab on the role of the hippocampus in updating remote memories. Fun putting this together with Ali Golbabaei.
authors.elsevier.com/a/1kZ4f3BtfH...

I’m old enough to remember when a person who dumped a dead bear cub in New York’s Central Park and tried to make it look like a bike accident might have trouble getting confirmed as Health and Human Services secretary.

The time course and organization of hippocampal replay The mechanisms by which the brain replays neural activity sequences remain unknown. Recording from large ensembles of hippocampal place cells in freely behaving rats, we observed that replay content i...

1/19 I’m thrilled that my postdoctoral work, with John Widloski and David Foster is now out in @science.org, along with a wonderful preview by Daniel Bendor!

Congrats!

Cells in the hippocampus encode not only information about a fellow bat’s position, but also its identity and distinct social features.

By @claudia-lopez.bsky.social

#neuroskyence

www.thetransmitter.org/social-behav...

Some thoughts on why I think the sister fields of Neuroscience and AI will diverge going forward.

Just giving this a boost for those who may not have seen it yet... we have a PI position (molecular and cellular basis of cognition) at The Hospital for Sick Children (Toronto). The position comes with an appointment at Assist/Assoc Prof level at U of T. Share widely!
can-acn.org/scientist-se...

Episodic and associative memory from spatial scaffolds in the hippocampus - Nature A neocortical–entorhinal–hippocampal network model based on grid cell states recapitulates experimental results and reconciles the spatial, associative and episodic memory roles of the hippocampus.

New modelling of how episodic memory can arise from spatial mapping, just out in Nature:

www.nature.com/articles/s41...