Luca Posa

Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain SBI-810, an arrestin-biased allosteric modulator of neurotensin receptor 1, can effectively alleviate acute and chronic pain in rodent models via peripheral and central modulation and can also mitigat...

So cool! 👇🏼👇🏼👇🏼A β-arrestin-2-biased modulator of neurotensin receptor 1 relieves acute and chronic pain by blocking neural sensitization while also reducing opioid abuse risk without affecting motor or cognitive functions

www.cell.com/cell/abstrac...

10.08.2025 02:14 — 👍 0    🔁 0    💬 0    📌 0

After 11 years on this continent, I’m starting to think natural selection has favored North Americans with a genetic tolerance (if not outright indifference) to noise pollution

01.08.2025 01:48 — 👍 1    🔁 0    💬 0    📌 0

A bit late but definitely proud of my first talk @INRC2025!

25.07.2025 02:04 — 👍 1    🔁 0    💬 0    📌 0

Sign it with your butt! 🤪

25.07.2025 02:02 — 👍 1    🔁 0    💬 0    📌 0

The neural basis of species-specific defensive behaviour in Peromyscus mice - Nature Visual threat triggers contrasting freeze and escape defensive responses in two species of deer mice as a result of different activation thresholds downstream of the superior colliculus in the do...

Defensive behaviour and dPAG 🐭

www.nature.com/articles/s41...

25.07.2025 02:00 — 👍 0    🔁 0    💬 0    📌 0

Great work! Congrats @flybottleescape.bsky.social and team!

25.07.2025 01:57 — 👍 1    🔁 0    💬 0    📌 0

My first time at #usasp2025. Great science, new and old friends. First talk in a symposium at an international conference. Thank you to my co-speakers @stefpuig.bsky.social and Ream Al-Asani

03.05.2025 01:40 — 👍 8    🔁 2    💬 0    📌 0

Predicting Individual Pain Sensitivity Using a Novel Cortical Biomarker Signature This cohort study analyzes electroencephalography data from healthy participants to analyze and validate a cortical biomarker signature for pain, which comprised the measures sensorimotor peak alpha f...

our NIH HEAL initiative funded biomarkers study now out @jama.com JAMA Neurology

open access, open data and code

w/ @drsmschabrun.bsky.social

jamanetwork.com/journals/jam...

27.01.2025 16:43 — 👍 33    🔁 15    💬 3    📌 3

Excited to present our lab's new work on GPCR antagonism: Contrary to popular belief, we propose that inverse agonists can bind to and act via GPCR:G protein complexes. We show this at KOR, through cellular assays, radioligand binding and cryoEM studies. A thread. 💊 🧪 www.nature.com/articles/s41...

07.01.2025 16:09 — 👍 70    🔁 18    💬 2    📌 0

Excited to share our new preprint here! A photocromic morphinian-azobenzene, efficacy switch and peripherally restricted analgesic. Great collaboration between Levitz, @dirktrauner.bsky.social @gati.bsky.social and Seva Katritch's labs! 👇🏻👇🏻 www.biorxiv.org/content/10.1...

23.12.2024 14:02 — 👍 4    🔁 1    💬 0    📌 0