Living Physics Lab

Top-down and bottom-up neuroscience: overcoming the clash of research cultures - Nature Reviews Neuroscience As scientists, we want solid answers, but we also want to answer questions that matter. Yet, the brain’s complexity forces trade-offs between these desiderata, bringing about two distinct research app...

𝐖𝐡𝐚𝐭 𝐰𝐞 𝐚𝐫𝐞 𝐫𝐞𝐚𝐝𝐢𝐧𝐠 “Top-down and bottom-up neuroscience: overcoming the clash of research cultures,” by Fernando Rosas @frosas.bsky.social 𝑒𝑡 𝑎𝑙. in 𝑁𝑎𝑡𝑢𝑟𝑒 𝑅𝑒𝑣𝑖𝑒𝑤𝑠 𝑁𝑒𝑢𝑟𝑜𝑠𝑐𝑖𝑒𝑛𝑐𝑒 www.nature.com/articles/s41...

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Reasoning Goals and Representational Decisions in Computational Cognitive Neuroscience: Lessons From the Drift Diffusion Model The appropriate form of the drift diffusion model depends on how one wishes to reason about their target with the model. If the goal is to parsimoniously explain the speed-accuracy tradeoff, the appr...

super excited that the first paper from my PhD is now out! we develop a "philosophical toolkit" for computational cognitive modeling & use it to conceptually re-analyze a long-standing debate about evidence accumulation models of decision making 🧠📈 onlinelibrary.wiley.com/doi/full/10....

@bbuchfink.bsky.social

@hajkdrost.bsky.social

Evolutionary Games: Mathematical Theory and Biological Insights

I am really happy to share that there will be a @nitmb.bsky.social workshop next year on mathematical and biological features of evolutionary game theory.

It was really fun to co-organize this workshop with Olivia Chu, Alex McAvoy, and @jplotkin.bsky.social.

www.nitmb.org/evolutionary...

New paper in @nature.com! With @kiseokmicro.bsky.social , Siqi Liu, Kyle Crocker, Jojo Wang, Mikhail Tikhonov & Madhav Mani — a massive dataset and simple model reveal a few conserved regimes that capture how soil microbiome metabolism responds to perturbations. www.nature.com/articles/s41...

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Thanks!

Mind sharing where you picked these up and what brand/manufacturer they are!

Great! Your talk on finding exactly the right age rock that was close enough to the surface to hunt for Tiktaalik fossils has stuck with me for decades. I’m from PA and I still haven’t managed to get to red hill road cut to try to search myself, but it’s on my bucket list.

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@olimeacock.bsky.social

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Theoretical Biology of the Cell Cambridge Core - Biological Physics and Soft Matter Physics - Theoretical Biology of the Cell

Just out from Cambridge University Press: Theoretical Biology of the Cell by Takagi, Furusawa, Sawai & Kaneko. Covers theoretical tools for life dynamics, stochasticity & information, for cellular response, adaptation, morphogenesis, origin of life & more

www.cambridge.org/core/books/t...

Another day, another @wgilpin.bsky.social paper I simply must read, I’m not finished with Panda yet!
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Plasmid-based one-pot saturation mutagenesis Deep mutational scanning is a foundational tool for addressing the functional consequences of large numbers of mutants, but a more efficient and accessible method for construction of user-defined muta...

Nicking mutagenesis with a very long mutagenic oligo? You’d have to talk to an expert about annealing temp etc for very long oligos pmc.ncbi.nlm.nih.gov/articles/PMC...

Waterproofing your Electronics Project We’ve been deploying our loggers under water since 2013 and although we’ve posted many detailed build tutorials along the way, it’s time to gather some of that distributed materia…

I’ve found this blog incredibly useful for environment proofing sensors!

thecavepearlproject.org/2023/03/17/w...

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@micromotility.bsky.social #livingphysics

Lenacapavir: The miracle drug that could end AIDS Hard Drugs · Episode

LAUNCH DAY 🚀

Today I’m launching a new podcast, Hard Drugs, with Jacob Trefethen (@jacobtref.bsky.social)

Our first episode is about lenacapavir — a new HIV drug that blocks infections with an efficacy rate of nearly 100%, and which could completely change the fight against HIV worldwide.

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