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Benjamin Buchfink

@bbuchfink.bsky.social

Independent scientist, Tübingen, Germany. Developer of the DIAMOND protein aligner. https://github.com/bbuchfink/diamond

48 Followers  |  108 Following  |  3 Posts  |  Joined: 10.01.2024  |  2.0354

Latest posts by bbuchfink.bsky.social on Bluesky

I knew early on I wanted to work with computers, but because of dyslexia I ended up in a lower-tier German school. The career office said a tech job wasn’t realistic. I ignored that, took a convoluted path into university, discovered bioinformatics, got hooked on algorithms&proteins, and became a PI

24.11.2025 02:41 — 👍 79    🔁 7    💬 2    📌 0
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GitHub - bbuchfink/diamond: Accelerated BLAST compatible local sequence aligner. Accelerated BLAST compatible local sequence aligner. - bbuchfink/diamond

DIAMOND v2.1.15 now supports all taxonomy features for BLAST databases, and support for using BLAST databases has also been added to the Bioconda version github.com/bbuchfink/di...

28.10.2025 16:45 — 👍 16    🔁 5    💬 0    📌 0
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Predicting functions of uncharacterized gene products from microbial communities - Nature Biotechnology FUGAsseM predicts protein function in microbiomes using coexpression patterns from metatranscriptomes and diverse community-wide data.

www.nature.com/articles/s41...

#microsky #microbiome

16.10.2025 04:50 — 👍 18    🔁 10    💬 0    📌 1

Ragnarok: a flexible and RApid GeNe Annotation (ROcKs) pipeline deployed through Nextflow https://www.biorxiv.org/content/10.1101/2025.10.03.680343v1

05.10.2025 01:47 — 👍 2    🔁 2    💬 0    📌 0
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Comprehensive taxonomic identification of microbial species in metagenomic data using SingleM and Sandpiper. #Metagenomics #MicrobialCommunities #Bioinformatics @natbiotech.nature.com 🧬 🖥️
www.nature.com/articles/s41...

31.07.2025 08:31 — 👍 8    🔁 3    💬 0    📌 0
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TaxTriage: An Open-Source Metagenomic Sequencing Data Analysis Pipeline Enabling Putative Pathogen Detection. #Metagenomics #Sequencing #PathogenDetection #Bioinformatics @biorxiv-bioinfo.bsky.social
www.biorxiv.org/content/10.1...

02.08.2025 09:15 — 👍 4    🔁 2    💬 1    📌 0

OrthoFinder just dropped a major update

It’s faster, more accurate, and ready for thousands of genomes

Let’s break it down (1/10)

github.com/OrthoFinder/...
www.biorxiv.org/content/10.1...

16.07.2025 17:51 — 👍 127    🔁 72    💬 1    📌 1
Logo for the Sandpiper website

Logo for the Sandpiper website

Out in @natbiotech.nature.com: Metagenome taxonomy profilers usually ignore unknown species. SingleM is an accurate profiler which doesn't, even detecting phyla with no MAGs. Profiles of 700,000 metagenomes at sandpiper.qut.edu.au. A 🧵

16.07.2025 21:59 — 👍 131    🔁 71    💬 7    📌 9
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GitHub - bbuchfink/diamond: Accelerated BLAST compatible local sequence aligner. Accelerated BLAST compatible local sequence aligner. - bbuchfink/diamond

DIAMOND v2.1.12 provides support for the new NCBI taxonomic ranks and various other fixes. github.com/bbuchfink/di...

02.06.2025 16:23 — 👍 0    🔁 1    💬 0    📌 0

Industry friends, now is the time for MUCH more speaking out on behalf of academic colleagues under duress. Here are core open source methods that many of your products doubtlessly depend on either directly or indirectly (see en.wikipedia.org/wiki/HMMER) being abruptly defunded. Make noise.

29.05.2025 14:39 — 👍 75    🔁 50    💬 1    📌 0

NIH funding supporting the HMMER and Infernal software projects has been terminated. NIH states that our work, as well as all other federally funded research at Harvard, is of no benefit to the US.

22.05.2025 12:42 — 👍 286    🔁 232    💬 37    📌 47

NIH just early-expired its 1st & only software NOFO: “Building Sustainable Software Tools for Open Science.” Our proposal supported lab automation software infrastructure, with backing from major robotics companies. I guess “sustainable” is too risky now. So much for funding the STEM workforce.

19.05.2025 19:14 — 👍 82    🔁 27    💬 3    📌 5
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GitHub - bbuchfink/diamond: Accelerated BLAST compatible local sequence aligner. Accelerated BLAST compatible local sequence aligner. - bbuchfink/diamond

DIAMOND v2.1.11 is now available, providing numerous improvements and fixes. github.com/bbuchfink/di...

25.01.2025 09:46 — 👍 2    🔁 1    💬 0    📌 0

@bbuchfink is following 20 prominent accounts