Manchester Cell Matrix Centre

We are celebrating Three Decades of Discovery and Excellence at the Cell Matrix Centre!

In preprints: a new preprint curation initiative from Development

In preprints: unpicking chemical and mechanical crosstalk for axonal pathfinding

Dionn Hargreaves and Sarah Woolner @mcrcellmatrix.bsky.social‬ discuss the #preprint from @evapillai.bsky.social‬ ‪@sudimukherjee.bsky.social‬ @franzelab.bsky.social‬ et al.
journals.biologists.com/dev/article/...

We had a great day today at the Translation Manchester Showcase. Let us know, what does Translational research mean to you?

Congratulations to Tony Day of @mcrcellmatrix.bsky.social @fbmh-uom.bsky.social on his election to the Academy of Medical Sciences (‪@acmedsci.bsky.social). Tremendous contributions to basic and translational research on proteoglycans.

Are you a PhD student or researcher passionate about cell-matrix research? Are you part of a research community that faces barriers to access or opportunity?

Our Visiting Scholar Scheme offers short-term research placements at the Manchester Cell-Matrix Centre.

Apply by May 30: lnkd.in/eppWKvH2

So excited to share our first neuro focused paper from the lab, we show that CXCL4 (PF4) is transported into the brain by proteoglycans within the endothelial glycocalyx and that GAG binding also mediates the pro neurogenesis effects of CXCL4. www.biorxiv.org/content/10.1...

YouTube video by Manchester Cell Matrix Centre Women in Science: Dharshika

Today at the Manchester Cell Matrix Centre, we're excited to showcase another Woman in Science, Dharshika Jayalath (Pathiranage), Dharshika is a lab manager, whose research focuses on the circadian clock and circadian rhythms.

Watch Dharshika's video here: youtube.com/shorts/bS-KL...

YouTube video by Manchester Cell Matrix Centre Women in Science: Dionn

Today at the Manchester Cell Matrix Centre, we're excited to showcase another Woman in Science, Dionn, a postdoctoral researcher specializing in Quantitative and Biophysical Biology.

Watch Dionn's video here: youtube.com/shorts/W57Gz...

YouTube video by Manchester Cell Matrix Centre Women in Science: Erin

At the Manchester Cell Matrix Centre, we're showcasing our researchers' through a new video series. Kicking off with Women in Science, today we highlight Erin, a PhD student studying the ImmunoMatrix in Complex Disease and Project Lead of Research Hive.

Erin's video youtube.com/shorts/2xT0q...

A fantastic postdoc opportunity available for talented PhD graduates to work in our CRUK funded PhD project.
jobs.manchester.ac.uk/internal/Job...
@mcr-breastcentre.bsky.social @mcrcnews.bsky.social @mcf-uom.bsky.social @mcrcellmatrix.bsky.social @official-uom.bsky.social @fbmh-uom.bsky.social

Macrophages promote collagen deposition through circadian regulation of fibroblasts Collagen deposition in fibroblasts, the primary collagen-producing cells, is regulated by both macrophages and the circadian rhythm, although how these regulatory processes interact with one another i...

Our lab's #1st manuscript from our #1st #PhD Katie is on #bioRxiv! Check it out 👇🏻

#macrophage regulation of fibroblast #collagen #circadian rhythm. #ImmunoECMatrix w/ @profandrewmac.bsky.social @tracyh9494.bsky.social @mcrcellmatrix.bsky.social @mcf-uom.bsky.social

www.biorxiv.org/content/10.1...

We had a great time yesterday taking some #TimetoTalk. We thank everyone who took the time out of their day to just simply connect.

Pink square graphic with black text which reads, 'World Cancer Day - 4 February'

In the UK, nearly 1 in 2 people will get cancer in their lifetime. It's World Cancer Day today – a global day to raise awareness and take action against cancer 🌍

Whatever your cancer experience, share this post and help us get the word out.

#WorldCancerDay #WCD2025

This research offers new insights into COVID-19 pathology and potential therapeutic targets. A great example of pushing the boundaries of matrix biology!

#MatrixBiology #Hyaluronan #LungHealth

@becky-dodd.bsky.social @profjudiallen.bsky.social

Research Associate - Mechanisms Associated with Extracellular Matrix Assembly and Stability at The University of Manchester Apply for the Research Associate - Mechanisms Associated with Extracellular Matrix Assembly and Stability role on jobs.ac.uk, the top job board for academic positions in higher education. View details...

We are hiring!!

How do basement membranes become stable structures during tissue growth? How can we measure turnover and dynamics?

Come and join our team to help us answer these questions!

@mcrcellmatrix.bsky.social
@stramerlab.bsky.social

More info 👇

www.jobs.ac.uk/job/DLN927/r...

The novel ECM protein SNED1 mediates cell adhesion via the RGD-binding integrins α5β1 and αvβ3 Summary: The recently discovered extracellular matrix protein SNED1 promotes the adhesion of breast cancer cells and neural crest cells via interaction with α5β1 and αvβ3 integrins, the first SNED1 re...

Our paper entitled "The novel #ECM protein SNED1 mediates cell adhesion via the RGD-binding #integrins α5β1 and αvβ3" is now published in #OpenAccess in @jcellsci.bsky.social @biologists.bsky.social. Big congrats Dharma pdtr124.bsky.social and Nandini! doi.org/10.1242/jcs....

(BBSRC NWD) Developing biomaterials to engineer how cancer cells sense force to regulate gene expression at The University of Manchester on FindAPhD.com PhD Project - (BBSRC NWD) Developing biomaterials to engineer how cancer cells sense force to regulate gene expression at The University of Manchester, listed on FindAPhD.com

📣 PhD opportunity in the lab!

💡 Are you interested in developing biomaterials to understand how cancer cells sense their surroundings to control gene activity?

🔗 For info on the project, and for details on how to apply, click here: www.findaphd.com/phds/project...

📧 Do get in touch if interested!

Please spread the word and sign up for our exciting spring meeting in Nottingham with amazing speakers on the topic of ECM, immunity and infection. An exciting and developing field! paacr4.wixsite.com/bsmb-spring2...

Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis Secretion and fibrillogenesis of collagen-I are separately controlled molecular pathways in the fibroblast, where surprisingly endocytic recycling is required for fibril formation and is increased in ...

Very glad to see this study finally out (and mentioned on bsky already!)- it's been a huge #collaboration across different groups🙏🏻

Fibroblasts recycles (in a #circadian manner) #collagen to make new fibrils, which is enhanced in #fibrosis.

doi.org/10.7554/eLif...
@elife.bsky.social

Manchester Cell-Matrix Centre members

We'll always have matrix... Happy holidays to all our members and collaborators.