Mia Levine's Avatar

Mia Levine

@levine-lab.bsky.social

Associate Professor @ Penn Biology, Penn Epigenetics Institute, Penn Center for Genome Integrity. We combine evolutionary genetics and cell biology to study how DNA repeat evolution perturbs and preserves genome integrity.

1,905 Followers  |  486 Following  |  23 Posts  |  Joined: 10.09.2023  |  2.3945

Latest posts by levine-lab.bsky.social on Bluesky

Attending #EMBOevoChromo25 next week? Our Reviews Editor @ingridtsang.bsky.social will be attending - feel free to talk to her about the journal or @biologists.bsky.social activities!

03.12.2025 18:23 β€” πŸ‘ 5    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0

@amberridgway.bsky.social can tell you... Good luck!

01.12.2025 19:40 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Joint profiling of gene expression and chromatin accessibility in pancreatic lymph nodes and spleens in human type 1 diabetes Joint chromatin accessibility and transcriptomic profiling of human and mouse pancreatic lymph nodes uncovers distinct features of CD4 T cells in T1D.

I am very excited to share our collaborative work on multiome profiling of gene expression and chromatin accessibility of more than 1 million immune cells in pancreatic lymph nodes and spleens in human type 1 diabetes in
@sciimmunology.bsky.social scim.ag/4o12TOZ

26.11.2025 18:55 β€” πŸ‘ 21    πŸ” 6    πŸ’¬ 3    πŸ“Œ 1

SAVE THE DATE: the yearly NY Population Genetics meeting will be back on March 9 2026, generously hosted by the
@simonsfoundation.org. Details to follow. Please RT.

14.11.2025 17:05 β€” πŸ‘ 52    πŸ” 39    πŸ’¬ 2    πŸ“Œ 3
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Pervasive suppressors halt the spread of selfish Segregation Distorter in a natural population - PubMed Meiotic drivers are selfish genetic elements that subvert Mendelian inheritance to increase their own transmission, yet they are typically found at low frequencies across natural populations. The factors that limit their spread remain unclear. To investigate this paradox, we studied the <i>Segregati</i> …

pubmed.ncbi.nlm.nih.gov/41278697/

29.11.2025 16:57 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Check out this terrific thread by first author, @sungyalin.bsky.social, whose creativity, bravery, exactitude, and perseverance made this project a reality.

29.11.2025 12:56 β€” πŸ‘ 7    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

Wow - thank you, Peter!

28.11.2025 17:24 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Rapid compensatory evolution within a multiprotein complex preserves telomere integrity Intragenomic conflict with selfish genetic elements spurs adaptive changes in subunits of essential multiprotein complexes. Whether and how these adaptive changes disrupt interactions within such comp...

How to keep in step when your (protein) partner speeds up…

Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.

Congrats to whole team!

www.science.org/doi/10.1126/...

28.11.2025 17:22 β€” πŸ‘ 116    πŸ” 63    πŸ’¬ 5    πŸ“Œ 4
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How do new centromeres evolve while staying compatible with the division machinery?

Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore.

πŸ‘‰ doi.org/10.1038/s41586-025-09779-1

26.11.2025 16:21 β€” πŸ‘ 181    πŸ” 84    πŸ’¬ 8    πŸ“Œ 8
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Meng-Chao Yao Obituary | 1949 - 2025 | Seattle Times View Meng-Chao Yao's complete obituary, share memories, and explore 1 tribute posts from the community.

Deeply saddened by the passing of my colleague, Prof. Meng-Chao Yao, a remarkable scientist and mentor. He left an indelible mark on all of us fortunate enough to know him. His legacy in molecular and ciliate biology will endure. Rest well, my friend. 1/

obituaries.seattletimes.com/obituary/men...

17.11.2025 23:24 β€” πŸ‘ 67    πŸ” 17    πŸ’¬ 1    πŸ“Œ 1
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I am looking to hire a postdoc interested in combining genetics and evolution to understand why telomeres vary so much in plants. My group has been developing Mimulus a genetic model for studying plant telomeres and we have really cool research brewing. Please check ad for detail. Deadline is 12/31.

16.11.2025 20:29 β€” πŸ‘ 38    πŸ” 37    πŸ’¬ 0    πŸ“Œ 0

Our NY area population genetics meeting is back and "upgraded", as Simons Foundation @simonsfoundation.org generously agreed to host. Please save the date: March 9, 2026. Look forward to seeing many of you from NY and beyond.

14.11.2025 17:58 β€” πŸ‘ 24    πŸ” 15    πŸ’¬ 1    πŸ“Œ 1
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Ecology and spread of the North American H5N1 epizootic - Nature The panzootic of highly pathogenic H5N1 since 2021 was driven by around nine introductions into the Atlantic and Pacific flyways, followed by rapid dissemination through wild migratory birds, primaril...

Our lab's paper describing the North American H5N1 epizootic is out now in Nature! So thrilled to have this out, and congratulations to @lambod50.bsky.social for all the fantastic work on this: www.nature.com/articles/s41...

12.11.2025 19:33 β€” πŸ‘ 137    πŸ” 65    πŸ’¬ 6    πŸ“Œ 7
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Insertion of an invading retrovirus regulates a novel color trait in swordtail fish For over a century, evolutionary biologists have been motivated to understand the mechanisms through which organisms adapt to their environments. Coloration and pigmentation are remarkably variable wi...

I am so excited to share new work on a TE insertion that regulates iridescence in swordtails, led by fantastic grad student @nadiahaghani.bsky.social and with help from many coauthors! In a time that has been so difficult to navigate, this & other projects have kept my spirits up: shorturl.at/NE65A

12.11.2025 20:34 β€” πŸ‘ 185    πŸ” 69    πŸ’¬ 3    πŸ“Œ 15

Are you an early-stage graduate student (2nd or 3rd year) or early-stage postdoc based in the US or Canada, working primarily in Drosophila? Would you like to help improve the experience of all trainees working in Drosophila research? If so, read on.

(Please repost to reach a broad audience.)

12.11.2025 04:49 β€” πŸ‘ 74    πŸ” 150    πŸ’¬ 1    πŸ“Œ 2
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Some impressions from the rather fabulous #EMBOmobilegenome Mobile Genome meeting in Heidelberg
Morning walk through the woods, exciting panel discussion, flash talks, lab community, drosophila friends, …
@events.embl.org

The transposon community is going very strong. see you all again in 2027!!

07.11.2025 07:37 β€” πŸ‘ 55    πŸ” 11    πŸ’¬ 2    πŸ“Œ 0
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio

Come be our colleague! The University of Rochester is hiring a TT Assistant Professor in evolutionary genetics and genomics: apply.interfolio.com/173431.

29.10.2025 14:12 β€” πŸ‘ 10    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0
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Molecular mechanisms of selfish elements and strategies Certain genes, chromosomes, organelles, or entire sets of chromosomes can bias their transmission to the next generation, propagating themselves at the expense of the rest of the genome. Referred to …

(1/9) Join us in Bern, Switzerland (8–11 Feb 2026) for our EMBO Workshop on Molecular Mechanisms of Selfish Elements and Strategies!

Organized with Tanja Schwander, Laura Ross (@laurarossevo.bsky.social) and Axel Imhof.

meetings.embo.org/event/26-sel...

#EMBOselfishElements #EMBOevents

27.10.2025 17:37 β€” πŸ‘ 9    πŸ” 15    πŸ’¬ 1    πŸ“Œ 0
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Ancient origin of an urban underground mosquito Understanding how life is adapting to urban environments represents an important challenge in evolutionary biology. In this work, we investigate a widely cited example of urban adaptation, Culex pipie...

How does life evolve to adapt to modern cities?

Out now in Science, my PhD work with @lindymcbr.bsky.social uncovers the ancient origin of the β€œLondon Underground mosquito” – one of the most iconic examples of urban adaptation.

🧡(1/n)
@science.org
www.science.org/doi/10.1126/science.ady4515

25.10.2025 04:45 β€” πŸ‘ 247    πŸ” 100    πŸ’¬ 8    πŸ“Œ 8

Yay, Cecile! So happy for you! Congratulations.

24.10.2025 16:57 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Antiviral reverse transcriptases reveal the evolutionary origin of telomerase Defense-associated reverse transcriptases (DRTs) employ diverse and distinctive mechanisms of cDNA synthesis to protect bacteria against viral infection. However, much of DRT family diversity remains ...

1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from?

Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...

17.10.2025 17:22 β€” πŸ‘ 220    πŸ” 103    πŸ’¬ 5    πŸ“Œ 16
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A histone methyltransferase-independent function of PRC2 controls small RNA dynamics during programmed DNA elimination in Paramecium Abstract. To limit transposable element (TE) mobilization, most eukaryotes have evolved small RNAs to silence TE activity via homology-dependent mechanisms

Our latest paper on a histone methyltransferase-independent function of PRC2 controlling small RNA dynamics during programmed DNA elimination in Paramecium is now published in #NAR.
#RNAbiology #TEsky #smallRNAs #PRC2 #DNAelimination
1/5
academic.oup.com/nar/article-...

17.10.2025 11:57 β€” πŸ‘ 54    πŸ” 25    πŸ’¬ 3    πŸ“Œ 1
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🚨 New paper alert on telomeres! 🚨
Something different from the group! Thanks to Yuxin, a talented student in the lab, we used long-reads in 75 human trios to study telomeres and their inheritance.

09.10.2025 05:33 β€” πŸ‘ 32    πŸ” 13    πŸ’¬ 3    πŸ“Œ 1

Ecstatic for you, Ish - big congrats! Excited for all the science to come.

09.10.2025 01:03 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Epistasis among clustered lineage-specific adaptive amino acid substitutions in the Drosophila Trio protein Intramolecular epistasis is increasingly recognized as a key factor shaping patterns of evolutionary rate variation among protein sites and constraining adaptive evolution. While genome-wide analyses ...
08.10.2025 11:44 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Long-read sequencing reveals telomere inheritance patterns from human trios https://www.biorxiv.org/content/10.1101/2025.10.07.680721v1

07.10.2025 23:32 β€” πŸ‘ 8    πŸ” 6    πŸ’¬ 1    πŸ“Œ 0

Check out this new Levine-Lampson collaboration, led by the talented Hyuk-Joon Jeon.

We explored the consequences of inheriting long telomeres from dad and short telomeres from mom. Or the reciprocal. Turns out, parent-of-origin matters (in mice, at least).

authors.elsevier.com/c/1loW-3QW8S...

04.10.2025 16:40 β€” πŸ‘ 49    πŸ” 20    πŸ’¬ 3    πŸ“Œ 3

Registration deadline for @embo.org workshop EvoChromo extended until September 30.

meetings.embo.org/event/24-evo...

14.09.2025 17:00 β€” πŸ‘ 12    πŸ” 11    πŸ’¬ 0    πŸ“Œ 0
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Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life.
www.nature.com/articles/s41...

24.09.2025 15:12 β€” πŸ‘ 225    πŸ” 106    πŸ’¬ 4    πŸ“Œ 10
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Unique genetic bases of repeated life-history divergence associated with high altitude adaptation in Mimulus perennials Understanding evolutionary repeatability is a central question in biology, as it informs how predictably organisms respond to similar selection pressures. However, the extent to which phenotypic repea...

This was a HUGE effort, taking years of diligent work. Hongfei was a true leader, and I'm really proud of this cool piece. We'd love any feedback y'all might have. www.biorxiv.org/content/10.1...

24.09.2025 16:55 β€” πŸ‘ 15    πŸ” 13    πŸ’¬ 0    πŸ“Œ 0

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