Alex Gould Lab

🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...

John Gurdon obituary: Biologist who made cloning possible He showed that specialized cells retain the genes to form an organism.

new out in Nature www.nature.com/articles/d41...

Calling early career PIs. A great opportunity to start your lab at @crick.ac.uk in the heart of London.

Abstract deadline (Dec 15th) approaching for the 2026 Neurogenesis meeting in Ascona. The last one was outstanding, so we’re all really looking forward to this second edition. Reassuringly in this day and age it’s held on the “Mount of Truth”.

Passionate about doing a PhD on metabolism in neural stem cells and their niche? The call just opened for applications for a PhD position in our lab @crick.ac.uk in London. Please repost.
tinyurl.com/ysnkdrmw

Excited to share our collaborative PhD project with Adam Dobson (Adam.Dobson@glasgow.ac.uk) on interorgan signalling in the ageing gut. Please contact Adam If you are a highly motivated student wanted to work on a super exciting Fly project.

LMB PhD studentship available in the Baum lab to use informatics to infer cell structure from genomic data in collaboration with the brilliant Tom Williams. If you write to me and I don’t reply - try again - the spam filter is hungry…

One of our favourite tabs is Resources: we're listing all of our datasets, codes, beginning to upload and make accessible raw imaging data and lab protocols. Please check it out, we hope this is useful!

niakanlab.com/resources/

Thank you to all #EDRC2025 participants and a big applause to the organizing committee for this great #Drosophila meeting! See you all in Bonn for #EDRC2027

The #EDS has the pleasure to announce that, after #EDRC2027 in Bonn, we will have #EDRC2029 in Szeged! Don’t forget these hashtags!

🪰 Calling all Drosophilists interested in nutrition…HolFast, Sebastian Sorge’s new chemically defined diet works really well. We’ve given some free HolFast aliquots to @vdrc-flies.bsky.social Please contact them directly if you fancy trying it out. Hurry while stocks last!

Dear JEDIs,
as we are self-organizing using the #EDRC as a nucleator we decided it is time for a JEDI database to boost our network! If you identify as a JEDI, please contact us here or send a mail to katja.rust@uni-marburg.de to be added to our database.
#Drosophila
@fly-eds.bsky.social

#Drosophila community - look at this amazing lineup for #InDRC2025

Registration for #InDRC2025 is now open! Visit indrc2025.in to register and submit your abstract.

#genetics #devbio
@flybase.bsky.social

Only a few hours left before our meeting starts! Are you travelling to #EDRC2025 now? Let us know by using the oficial #EDRC2025 hashtag!

Trump's Harvard cuts threaten a giant in biomedical research: A database about the tiny fruit fly This spring, the Trump administration rescinded a grant that maintained FlyBase, a pillar of global basic research, as part of its broader $2.2 billion funding cuts at Harvard.

The FlyBase situation has made the national news www.nbcnews.com/science/scie...

Drosophila research without FlyBase would be untenable. Time for all labs who can afford it to step up.

Glucose-dependent insulinotropic polypeptide receptor signaling in oligodendrocytes increases the weight-loss action of GLP-1R agonism Hansford et al. show that GIPR, a target of new weight-loss drugs, is found in brain cells called oligodendrocytes. GIPR helps these drugs access the brain and boosts weight loss. Without GIPR in thes...

Expanding metabolic roles for the GIPR in oligodendrocytes #weightloss www.cell.com/cell-metabol...

12 examples of how developmental biology research led to fundamental discoveries for biomedical research. There are many more! Download ppt & jpg versions on @socdevbio.bsky.social website. Use & modify as needed. Poster formats are also posted to print & hang in your lab!

Open positions GR-SCHUHMACHER

We are hiring!

If you are looking for a postdoc position and you are interested in signaling lipids and proteomics, come join us in beautiful Switzerland!

More information on www.epfl.ch/labs/gr-schu...

How scientists can contribute to the social movements essential to protecting climate and nature - npj Climate Action Scientists have much to contribute to the growing social movements pushing for urgent and transformative change to address the climate and biodiversity crises. Depending on their skills, interests and...

www.nature.com/articles/s44...

Somatic cells compartmentalise their metabolism to sustain germ cell survival To ensure success in reproduction, organisms dedicate substantial resources to supporting the germline. In testes, somatic gonadal cells form a barrier that isolates germ cells from circulating nutrie...

🆕🧪‼️
New lab preprint!
We study how germ cells (the cells that give rise to gametes, in this case sperm) are supported by somatic (non-germ) cells of the gonad. This matters for our understanding of reproduction - without germ cell development, animals are sterile.
www.biorxiv.org/content/10.1...

Event carbon calculator - the Node I am excited to announce the release of our event carbon calculator, our latest resource to support the creation of sustainable events. Estimate your

Calling all meeting organizers… @biologists.bsky.social now have a calculator to estimate your event’s carbon footprint and to test various reduction scenarios.

thenode.biologists.com/event-carbon...

In defense of silly science A biologist pushes back against attacks on curiosity-driven research

In defense of silly science | Science www.science.org/doi/10.1126/...

#Drosophila @flybase.bsky.social requires emergency funding:
"As it stands, by the end of July, 2025, there will be no future updates to #FlyBase, and in the worst case scenario access to the website will also be lost". Please help if you can!

Calling all European #Drosophila labs. Time for all of us, that are able, to step up to support FlyBase during this funding crisis.

Image shows two speech bubbles in yellow and blue, the Node logo and the text: "Have your say - take our survey and help shape the future of the Node."

As we turn 15, we want to collect feedback from you, our community, to ensure the Node is still relevant and useful. If you’ve ever visited the Node to read, write and interact with the #DevBio & #StemCell community, thank you!

Please spare 5min to take our survey:
www.surveymonkey.com/r/7QHYQCW

"Thinking time —the time needed to concentrate without interruptions has always been central to scholarly work. It is essential to designing experiments, compiling data, assessing results, reviewing literature and, of course, writing. Yet, [it] is often undervalued."
www.nature.com/articles/d41...

Calling all #Drosophilists Congrats to @adrienfranchet.bsky.social and Dominique Ferrandon.

And cite the model organism databases and other resources you use!