5/5-The multiscale protein patterns map a pathophysiology composed of interrelated elements that are likely to play roles in ME/CFS.

4/5-Focused studies of secreted proteins (the secretome) supported intensified regulatory interactions related to immune activity, inflammation, vasculature, and metabolism.

3/5-The widespread decrease of intracellular proteins in the blood (especially from skeletal muscle) may have different explanations - muscle mass, cell/tissue turnover, tissue perfusion, and more.

2/5-Distinct patterns of tissue- and process-specific changes were seen, including broad increase in secreted proteins, effects on metabolic regulators and changes in immune cell-specific signatures - with a specific reduction in neutrophil-associated proteins.

Charting the Circulating Proteome in ME/CFS: Cross System Profiling and Mechanistic insights Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating condition often triggered by infections. The underlying mechanism remains poorly understood, and diagnostic markers and ef...

Charting the Circulating Proteome in ME/CFS: Cross System Profiling and Mechanistic insights www.medrxiv.org/content/10.1...
1/5-Our new preprint on the blood proteome of ME/CFS is a deep dive into the pathophysiology. ~7000 blood proteins were measured in 54 ME/CFS and 27 healthy.