Yesterday, @antonvenhuizen.bsky.social successfully defended his thesis "Molecular mechanisms of the
Ξ²-catenin destruction complex in health and disease", which describes the versatile field of WNT regulator AXIN1.
We are super proud and wish Dr. Venhuizen all the best in Cambridge!
08.05.2025 07:39 β π 5 π 1 π¬ 0 π 0
Center for Molecular Medicine
Our Center for Molecular Medicine (cmmutrecht.eu) at UMC Utrecht, NL, is looking for a Principal Investigator in the field of fundamental Cancer Biology! The vacancy states tenure track level, but candidates with a more advanced career are very welcome to apply. shorturl.at/KZeYQ. Please repost!
07.02.2025 12:09 β π 5 π 9 π¬ 0 π 0
Want to learn the latest insights on how Wnt signaling controls cell behavior?
Check out a new review by Madelon Maurice (@madelonmaurice.bsky.social) and Stephane Angers at @natrevmcb.bsky.social
29.01.2025 12:21 β π 10 π 2 π¬ 0 π 0
Great work by @joepsprangers.bsky.social and more members from the lab! And that 3 days after receiving his doctorate!!!π
22.12.2024 22:31 β π 2 π 0 π¬ 0 π 0
WNT7B drives a program for pancreatic cancer subtype switching and progression
Hyperactivation of WNT signaling is a well-established hallmark of cancer. Various epithelial cancers express high levels of WNT7B and WNT10A that are not commonly expressed during tissue homeostasis,...
Pre-print Alert! π’
Proud to share our insights on WNT7B driving pancreatic cancer progression. Sprangers et al uses organoids to show that WNT7B employs short-range signaling driving tumor growth and mediate a shift of PDAC cells towards a more aggressive phenotype
www.biorxiv.org/content/10.1...
22.12.2024 20:30 β π 16 π 5 π¬ 1 π 0
π Huge congratulations to Dr. Joep Sprangers! Yesterday, Joep successfully defended his PhD thesis and officially became a doctor! His studies describe the role of WNT7B and WNT10A in regeneration, homeostasis, and cancer.
It was a very special day, couldnβt be prouder.
19.12.2024 11:14 β π 11 π 1 π¬ 0 π 0
Yesterday, our lab turned festive for late Sinterklaas/early Christmas! π With poems, laughter, and guessing games, we shared stories, gifts, and some surprising personal details. Add drinks, snacks, and a digital fireplace, and it was a night of bonding, cheer, and fun!β¨#LifeOutsideTheLab
11.12.2024 11:32 β π 3 π 0 π¬ 0 π 0
Our first post on BlueSky is here π¦. Great story from @antonvenhuizen.bsky.social from our lab describing the role of AXIN1 mutations in hepatocellular carcinoma. Congrats to Anton for the hard work and the deserved BioRxiv pre-publication! π₯³
www.biorxiv.org/content/10.1...
09.12.2024 11:53 β π 7 π 0 π¬ 0 π 0
Scientist with a passion for genomic integrity and a passion to optimally connect research and care in oncology.
Group leader at the Institute of Experimental Paediatric Haematology and Oncology at the Goethe University Frankfurt, Germany. Ubiquitin, autophagy, cell death, inflammation. Immigrant. (all views my own).
Our lab in Czechia investigates cellular signaling during developmental and homeostasis processes using a Xenopus embryo πΈ and tissue cells π§«.
See more atπ
https://www.sci.muni.cz/ofiz/en/harnos-lab-2/
Alumni @CDRBSinai (πΊπΈ), @uniwuerzburg (π©πͺ)
Laboratory of Cellular Communication
Department of Experimental Biology, Faculty of Science, Masaryk University
WNT signalling || CK1 || DVL || planar cell polarity || CLL || AML || melanoma || migration || choroid plexus ||
https://www.sci.muni.cz/ofiz/en
Postdoc @ FMI Basel (Turco Lab) | Exploring endometrium regeneration & niche π±π©Έ | Human model systems + single-cell genomics + evo-devo | Former PhD @ IHB (Camp Lab)
Postdoc in the Clevers lab @HubrechtInstitute
Fascinated by: Organoids, Stem cells, Development, Gene editing.
Assistant Professor at Wilhelmina Children's Hospital, UMC Utrecht, RMCU. Advanced human disease models for pulmonary disease.
PostDoc @TUM π©πͺ | functional genomics | GI tract cancer | organoids | plasticity | signaling | PhD from @UMCU π³π±
Junior Group Leader @www.Helmholtz-Munich.de
We investigate how Aging & Environmental Stress at epithelial barriers (gut & π«) facilitate chronic inflammatoryπ₯ diseases, using innovative 3D organoid cultures π§«
https://www.funk-lab.de
Postdoctoral researcher at UMC Utrecht. Fascinated by early stage colorectal cancer.
Professor @ Goethe Uni & IBC2-GU, Co-founder of Vivlion. #BerlinER #FrankfurtER
PhD student at Institute of Human Biology (IHB) π¨π Studying enteroendocrine cells using gastric and intestinal organoids
Computational Scientist at HI-STEM / DKFZ.
Heterogeneity in cancer | Computational Biomedicine
Structural biologist and biochemist, interested in ubiquitin enzymes and DNA repair & regulation
Endocrinology, endocrine oncology, gender-affirming hormone therapy, functional epigenetics
Professor, Founder and Director of the Centre for Targeted Protein Degradation at the University of Dundee. We develop molecules that induce protein interactions and degradation
Group Leader @EMBLBarcelona | PD @TheCleversLab | PhD @MITBiology (Jacks lab) | B.A. @NewCollegeofFL | She/her | π΅π·πΊπΈπͺπΊ| #Organoids, #Neuroendocrine cells
Physician Scientist at Memorial Sloan Kettering | Metastasis | Plasticity | Colorectal Cancer | Regeneration | Stem Cells | Organoids | posts my own and do not represent MSK