Jeroen Bugter

Mechanosensitive calcium channels and integrins coordinate the reprogramming of colorectal cancer cells into a fetal-like state van der Net et al. show that mechanical interactions with the stromal component collagen I trigger reprogramming of colorectal cancer cells into a fetal-like state, through mechanosensitive integrins ...

We finally made it over here ! And excited to share our new paper on mechanical forces regulating stem cell plasticity in colorectal cancer, involving force transduction via mechanosensitive calcium channels! www.cell.com/cell-reports...

07.11.2025 16:32 — 👍 41    🔁 13    💬 1    📌 0

Investigating non-proliferative cell states with inducible CRISPR screens Nature Protocols, Published online: 08 October 2025; doi:10.1038/s41596-025-01252-7CRISPR screens are widely used to identify essential genes and potential drug targets, but typical setups were designed for the study of highly proliferative cancer cell lines. Now, a protocol, using inducible Cas9, enables screens of non-proliferative cell states including senescence, quiescence and terminal differentiation, thereby expanding the applicability of CRISPR screens.

New Article! Investigating non-proliferative cell states with inducible CRISPR screens

08.10.2025 20:29 — 👍 4    🔁 1    💬 0    📌 0

BRAFV600E augments WNT signaling in colorectal cancer via aberrant DNA methylation Epigenetics; Cell biology; Cancer

www.cell.com/iscience/ful... and www.cell.com/iscience/ful...

15.08.2025 13:03 — 👍 1    🔁 0    💬 0    📌 0

BRAF V600E drives serrated colon cancer, but is it essential in late stages? Reverting BRAF to wild type in patient-derived CRC organoids shows it maintains abnormal DNA/chromatin methylation, affecting WNT-pathway genes. Two back-to-back
@cp-iscience.bsky.social
papers led by Layla El Bouazzaoui.

15.08.2025 13:03 — 👍 2    🔁 0    💬 1    📌 0

Amazing work!

24.07.2025 20:10 — 👍 1    🔁 0    💬 1    📌 0

Cool findings! Congrats!

24.07.2025 19:43 — 👍 1    🔁 0    💬 0    📌 0

Fascinating work! Congrats!

24.07.2025 18:19 — 👍 1    🔁 0    💬 0    📌 0

WNT7B drives a program for pancreatic cancer subtype switching and progression Hyperactivation of WNT signaling is a well-established hallmark of cancer. Various epithelial cancers express high levels of WNT7B and WNT10A that are not commonly expressed during tissue homeostasis,...

Pre-print Alert! 📢
Proud to share our insights on WNT7B driving pancreatic cancer progression. Sprangers et al uses organoids to show that WNT7B employs short-range signaling driving tumor growth and mediate a shift of PDAC cells towards a more aggressive phenotype

www.biorxiv.org/content/10.1...

22.12.2024 20:30 — 👍 16    🔁 5    💬 1    📌 0