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Mike Filius

@mikefilius.bsky.social

236 Followers  |  34 Following  |  7 Posts  |  Joined: 13.11.2024  |  1.6839

Latest posts by mikefilius.bsky.social on Bluesky

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Generative Design of High-Affinity Peptides Using BindCraft Discovering high-affinity ligands directly from protein structures remains a key challenge in drug discovery. We applied BindCraft, a structure-guided generative modeling platform, to de novo design o...

"Generative Design of High-Affinity Peptides Using BindCraft".

New @biorxivpreprint.bsky.social by the group of @sebastianpomplun.bsky.social of our @led3hub.bsky.social!

www.biorxiv.org/content/10.1...

Cc: @leidenscience.bsky.social, @unileiden.bsky.social

26.07.2025 10:07 β€” πŸ‘ 11    πŸ” 3    πŸ’¬ 0    πŸ“Œ 1

Thanks for sharing our work Stephan!

27.07.2025 09:37 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Check out our latest work:
β€œGenerative design of high-affinity peptides using BindCraft” now on bioRxiv

BindCraft generates peptide binders for MDM2 and WDR5 with nanomolar affinitiesβ€”further enhanced through rational chemical modifications.

Huge thanks to the amazing team putting this together! πŸ™Œ

27.07.2025 08:30 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Generative Design of High-Affinity Peptides Using BindCraft

www.biorxiv.org/content/10.1...

26.07.2025 09:53 β€” πŸ‘ 15    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0

Was great showing our work on single molecule analysis of aptamer-protein interactions at the #LED3Symposium

19.06.2025 14:50 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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A PhD position is open for this year. A candidate should have a background in programming skills.

10.03.2025 16:28 β€” πŸ‘ 5    πŸ” 8    πŸ’¬ 0    πŸ“Œ 1

🚨New paper alert! 🚨

Today in @naturesmb.bsky.social we uncover how the oxidoreductase PYROXD1 protects the human tRNA ligase complex against oxidative stress. A great collaboration between the @martinjinek.bsky.social lab and the Javier Martinez lab.

www.nature.com/articles/s41...

11.03.2025 10:14 β€” πŸ‘ 14    πŸ” 3    πŸ’¬ 3    πŸ“Œ 0

New year. New social media platform #BlueSky and a New job as a postdoc @unileiden.bsky.social Super excited to start this next adventure.

Happy new year to all!

01.01.2025 14:23 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Great stuff from a great friend @lloeff.bsky.social on the underlying mechanism of the Shedu anti-phage defense system. #HappyReading :)

31.12.2024 16:02 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0

Congrats Tim and team! Very cool to see you guys lowering the bar for people to use single molecule tech :) keep up the good work!

26.11.2024 04:57 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Hi Johannes, great stuff! Could you add me in the group?

13.11.2024 19:47 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

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