Cesar Cobaleda's Avatar

Cesar Cobaleda

@cjchcm.bsky.social

Biologist. Scientist. Curious. Researcher in rare diseases, cancer, hematopoiesis, epigenetics and bioinformatics, at CBM (CSIC)

69 Followers  |  101 Following  |  8 Posts  |  Joined: 15.11.2024  |  1.4154

Latest posts by cjchcm.bsky.social on Bluesky

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On #WorldBlood#CancerDay, let’s remember those affected and raise awareness about these diseases. Explore the main types of blood cancer and how they impact the body 👇

🔗 https://bit.ly/4kkBfvA

#HemeSky #MedSky #HemeOnc

28.05.2025 17:01 — 👍 11    🔁 6    💬 1    📌 0

📣 We are super happy to share our new preprint!
We show how an imbalance between replication and transcription elongation rates can be uncoupled genome-wide without replicative stress 1/3

16.05.2025 13:32 — 👍 4    🔁 3    💬 1    📌 0

Once you have enough knowledge of the literature in your research field, you realize you’ll never have enough knowledge of the literature in your research field.

15.05.2025 11:11 — 👍 1    🔁 0    💬 0    📌 0

I am not necessarily against the initiative, but would a chimpanzee with 20 gene edits be human?

If you lined up a dire wolf genome with a gray wolf genome there would be millions of differences. These individuals seem optimistically 1/100,000th dire wolf. (No paper or preprint available though).

07.04.2025 19:07 — 👍 41    🔁 12    💬 2    📌 2
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Federico Mayor Zaragoza obituary: former UNESCO chief who championed neonatal screening The biochemist introduced the first heel-prick tests for newborn babies in Spain, protecting infants from life-changing metabolic conditions.

www.nature.com/articles/d41...

13.02.2025 17:10 — 👍 0    🔁 0    💬 0    📌 0
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Engineering synthetic signaling receptors to enable erythropoietin-free erythropoiesis - Nature Communications Shortages of donor blood for transfusions can have severe medical consequences, and ex vivo production of red blood cells offers a potential solution. Here authors developed synthetic EPO receptors, w...

www.nature.com/articles/s41...

30.01.2025 07:47 — 👍 0    🔁 0    💬 0    📌 0
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Meinrad Busslinger, Emeritus Senior Group Leader at the IMP, received the Silver Medal for Meritorious Service to Vienna for his outstanding scientific achievements & key role in establishing the IMP and Vienna BioCenter. 🎖️👏

Read more: www.imp.ac.at/news/article...

@viennabiocenter.bsky.social

28.01.2025 15:37 — 👍 21    🔁 4    💬 0    📌 1
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The contentious genius who made black holes real Roger Penrose, now 93, never shied away from wild ideas and the ensuring debates. The first full-length biography reveals more about the mathematician and the man.

www.nature.com/articles/d41...

05.12.2024 18:19 — 👍 0    🔁 0    💬 0    📌 0
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Evidence of oldest known alphabet unearthed among Syrian tomb treasures Cylinders discovered in 2004 are inscribed with the earliest known examples of letters, say archaeologists.

www.nature.com/articles/d41...

05.12.2024 18:19 — 👍 0    🔁 0    💬 0    📌 0
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Long-term lineage commitment in haematopoietic stem cell gene therapy - Nature Haematopoietic stem cell (HSC) clonogenic activity, lineage output, lineage commitment and somatic mutation rates are influenced by the underlying disease, patient age, extent of genetic defect correc...

www.nature.com/articles/s41...

05.12.2024 18:17 — 👍 0    🔁 0    💬 0    📌 0
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We used to hear the term "tired blood." [Geritol]
Now it's tired proteins. Proteolethargy. Reduced protein mobility as an underpinning for chronic diseases
www.cell.com/cell/abstrac...

27.11.2024 19:39 — 👍 220    🔁 54    💬 3    📌 4

In the end, it comes down to whether one believes the system generally allocates resources in ways that predict rather than fuel success. Between the tails of the distribution, I don’t think it does.

28.11.2024 16:47 — 👍 10    🔁 1    💬 1    📌 0
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Loss of Earth’s old, wise, and large animals Earth’s old animals are in decline. Despite this, emerging research is revealing the vital contributions of older individuals to cultural transmission, population dynamics, and ecosystem processes and...

No planet for old animals 😢

www.science.org/doi/10.1126/...

22.11.2024 15:37 — 👍 0    🔁 0    💬 0    📌 0
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The metaphors of artificial intelligence A few months after ChatGPT was released, the neural network pioneer Terrence Sejnowski wrote about coming to grips with the shock of what large language models (LLMs) could do: “Something is beginning...

www.science.org/doi/10.1126/...

19.11.2024 16:07 — 👍 1    🔁 0    💬 0    📌 0

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