Sander W van der Laan's Avatar

Sander W van der Laan

@swvanderlaan.bsky.social

Assist. Prof. @UMC_Utrecht @AtheroExpress | cardiovascular genetics | @AtheroNL @EAS @StrokeGenetics | father of 3 | πŸ‘¨πŸ½β€πŸ’» | @OpenSciUtrecht

294 Followers  |  54 Following  |  34 Posts  |  Joined: 30.10.2023  |  2.6524

Latest posts by swvanderlaan.bsky.social on Bluesky

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Major depression and atherosclerotic disease: Linking shared genetics to pathways in blood, brain, heart, and atherosclerotic plaques Background The increased risk of atherosclerotic diseases (stroke, coronary artery disease [CAD]) observed in depression may stem from shared pathophysiology. We examined whether: 1) major depression ...

🚨 Preprint Alert 🚨
"Major depression and atherosclerotic disease: linking shared genetics to pathways in blood, brain, heart, and atherosclerotic plaques. " πŸ§ πŸ«€πŸ©Έ The title says it all. Great collaboration with @swvanderlaan.bsky.social . πŸ“„ Read it here: bit.ly/4eTM8T2

15.07.2025 12:47 β€” πŸ‘ 9    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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ESC 365 - the cardiology knowledge hub ESC 365 is the cardiology knowledge hub where you’ll find resources, whenever you want them from congresses, webinars, courses, publications and podcast.

The Future is Now. Jessica van Setting hosting Folkert Asselbergs and Pim van der Harst to talk about AI with ESC and funded by @erc.europa.eu.

More on www.nextgentools.eu.

#NextGen #AI #artificialintelligence #ESC #Horizon

esc365.escardio.org/event/2083

10.07.2025 08:06 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Invasion of the β€˜journal snatchers’: the firms that buy science publications and turn them rogue Study finds dozens of journals that have hiked their fees and started churning out papers after being acquired by small, recently formed companies.

β€œResearch-integrity analysts are warning that β€˜journal snatchers’ β€” companies that acquire scholarly journals from reputable publishers β€” are turning legitimate titles into predatory, low-quality publications with questionable practices”
#HigherEd #Journals πŸ§ͺ #Research
www.nature.com/articles/d41...

17.04.2025 22:01 β€” πŸ‘ 18    πŸ” 15    πŸ’¬ 1    πŸ“Œ 0

Tim Peters wrote a ✨ great blogpost ✨in laymen's terms on our paper. Check it out here πŸ‘‰πŸ½ www.vanderlaanscience.nl/news/phenomicl

18.03.2025 15:39 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Unraveling the Heart of Type 1 Diabetes β€” Van der Laan & Science Unraveling the Heart of Type 1 Diabetes: on our U01 grant to study the immune-link between type 1 diabetes, type 2 diabetes and cardiovascular disease.

Did we tell you about this news?

www.vanderlaanscience.nl/news/care-t1d

Glad for the support to be able to collaborate with @clintomics.bsky.social Suna Onengut-Gumuscu and @metecivelek.bsky.social from #UVA.

14.03.2025 15:48 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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AtheroNETH β€” Van der Laan & Science AtheroNETH: finding biomarkers and druggable targets for personalized primary prevention.

And also very grateful to be part of #AtheroNETH.

www.vanderlaanscience.nl/news/atheron...

This major project is truly a remarkable collaboration involving researchers from all major university medical centers in The Netherlands.

#TeamScience #Hartstichting

14.03.2025 15:42 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Excited to finally share our work on attention-based multiple instance learning to quantify and characterize intraplaque haemorrhage in carotid plaque whole slide images from >2500 patients in AtheroExpress. Fun collaboration with @swvanderlaan.bsky.social and Craig Glastonbury labs.

07.03.2025 20:27 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

5/ πŸ™πŸ½ Special thanks to our πŸ’« collaborators at @umcutrecht.bsky.social (Tim Peters), the University of Virginia #UVA (@clintomics.bsky.social, Yipei Song), and @humantechnopole.bsky.social (Francesco Cisternino & Craig Glastonbury) for their invaluable contributions 🫢🏽πŸ’ͺ🏽!

#ResearchCollaboration
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07.03.2025 15:21 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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4/ This advancement helps link IPH to key clinical outcomes and understand its biological mechanism, advancing cardiovascular care and research. πŸ’™ Discover our study πŸ”—

doi.org/10.1101/2025...
#CardioResearch #AIinHealthcare

07.03.2025 15:21 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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3/ Our model precisely localises IPH within plaques, quantifying its area and facilitating downstream analyses of its association with clinical 🩺 outcomes and molecular 🧬 features.

07.03.2025 15:21 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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2/ With data from the @atheroexpress, we developed a framework to analyse whole-slide imagesπŸ”¬ for better IPH detection and analysis. πŸ“Š H&E staining showed strong results, and combining it with other stains further improved accuracy.

07.03.2025 15:21 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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πŸš€ Thrilled to announce our latest #preprint on intraplaque haemorrhage (IPH) quantification and molecular 🧬characterisation of carotid plaques using deep learning. A thread πŸ§΅πŸ‘‡πŸ½

07.03.2025 15:21 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 1    πŸ“Œ 2

Intraplaque haemorrhage quantification and molecular characterisation using attention based multiple instance learning https://www.medrxiv.org/content/10.1101/2025.03.04.25323316v1

06.03.2025 22:56 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Opinion | Will They Come for PubMed Next? Here's what we lose if the administration takes away this invaluable resource

Will They Come for PubMed Next? www.medpagetoday.com/opinion/seco...

02.03.2025 10:19 β€” πŸ‘ 2    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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Lessen trekken uit het nazisme: menselijk fatsoen blijkt uiterst fragiel Geschiedenis: Een groot kenner van de geschiedenis van het nazisme laat zien: de mentaliteit en de technieken van Hitler en consorten zijn allesbehalve verleden tijd. The Nazi Mind zou ons aan het den...

'Exploiteren wij/zij-denken, ontmenselijken minderheden, verspreiden complottheorieΓ«n, hameren op vijandbeelden, je minder radicaal voordoen dan je bent, opjutten jongeren, heldenverering, ondermijnen rechtsstaat, kritiek verdacht maken, verzet kop indrukken – herkenbaar?'
www.nrc.nl/nieuws/2025/...

28.02.2025 07:05 β€” πŸ‘ 91    πŸ” 52    πŸ’¬ 5    πŸ“Œ 8

What about the many science tv and streaming services shows? You know, the likes of David Attenborough and Stephen Hawking, for example? Discovery Channel? And all those different magazines for all ages and subgroups? Wikipedia for years? And now ChatGPT? Seems #Science is more accessible than ever…

01.03.2025 20:06 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

There is strong evidence of Russian intervention and influence in recent Western voting - not least in the USA with the election of a president who echoes Russian propaganda, fires military top brass, weakens alliances, threatens neighbours,, drops cyber security against Russia and bullies Ukraine.

01.03.2025 14:32 β€” πŸ‘ 20    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0

The potential! We can easily double the *actual* data sharing by the end of this year #DutchScientists!

#ScienceMatters #OpenSciencw #OpenAccess

10.02.2025 21:42 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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To what extent do researchers funded by Dutch Research Council NWO and ZonMw share the research data and code underlying their publications?

Today we published an analysis based on 10.000+ papers using the open source tool Grobid: www.nwo.nl/en/news/shar...

All underlying data openly available!

10.02.2025 21:10 β€” πŸ‘ 30    πŸ” 12    πŸ’¬ 0    πŸ“Œ 1
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Opinion | How to Fix America’s Two-Party Problem (Gift Article) Proportional representation could help restore American democracy.

Who or what would be opposed?

#representativevoting

www.nytimes.com/interactive/...

#usa #election

14.01.2025 18:24 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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"Forum voor Democratie strijdt tegen universiteiten en wetenschappelijk onderzoek” - ScienceGuide Uit nieuw wetenschappelijk onderzoek van de Universiteit van Oslo blijkt dat Forum voor Democratie (FvD) systematisch probeert het vertrouwen in Nederlandse universiteiten en wetenschappelijk onderzoe...

Interessant.

Ik bedenk mij ook dat mensen allerlei labels geven niet perse helpt ('rechts-radicaal', 'linkse rakker', etc). En dat geldt dan voor alle betrokken partijen. Waarom zou de een dan nog met ander willen praten, of andersom?

www.scienceguide.nl/2025/01/foru...

08.01.2025 13:40 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Also, we do not need money to apply a different approach to appreciating work.

It's just an alternate approach to managing how we all work in #academia. It's about changing a culture. You don't need money for that.

08.01.2025 13:31 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Niet verzet vanuit wetenschap en politiek, maar bezuinigingen bedreigen Erkennen en WaarderenΒ  - ScienceGuide Het Nederlandse Erkennen en Waarderen-programma, in 2019 gelanceerd om de beoordeling van wetenschapAlleen de koppen lezen, maar de informatie missen? Voor € 85, - per jaar krijgt u onbeperkt toegang ...

Good good. The Future of Science *is* Open.

Agreed: failing actually means learning. Fail fast and often, and you learn.

#openscience #rewards #recognition

www.scienceguide.nl/2024/12/niet...

08.01.2025 13:31 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Narratief CV bij NWO-beursaanvragen werpt nieuw licht op excellent onderzoek - ScienceGuide Sommige wetenschappers die voor NWO-onderzoeksbeurzen moeten beoordelen, blijven ijzerenheinig vasthouden aan publicatiemetrics, maar meestal gaat het wel goed en blijkt er door het narratieve CV lang...

Interesting findings below. But @scienceguide.bsky.social : where is the link to the actual research?

#openscience #rewards #recognition #science

www.scienceguide.nl/2025/01/narr...

08.01.2025 11:42 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

That said: they do have disease-causing effects and it is wise to try to minimize ingestion of #microplastics as much as possible. Read: where you can control it. For instance, drinking water from a metal bottle instead of a plastic one.

23.11.2024 21:02 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Ingested microplastics: Do humans eat one credit card per week? Ingested Microplastic (MP) particles can harm the human body. Estimations of the total mass of ingested MP particles correspond to 50 plastic bags per…

We don’t have to panic, it is unlikely we ingest a credit card’s worth of #microplastics πŸ‘‡πŸ½
www.sciencedirect.com/science/arti...

23.11.2024 21:02 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Next they associated the presence of #microplastics with whether or not had a stroke or a heart attack or death from any cause. Perhaps that’s the origin of the confusion.

Anyway, the facts remain: #microplastics are all around us and they get in our bodies.

23.11.2024 21:02 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

They found #microplastics in carotid plaques, *not* in the heart. These patients were operated (carotid endarterectomy) on the arteries (carotids) in the neck supplying blood to the brain which were partially blocked. The surgeons cleared this blockage, aka they took out the β€œplaque”.

23.11.2024 21:02 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Both posts note that #microplastics are found in the plaques taken from the heart. That is not entirely the case.

23.11.2024 21:02 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

@swvanderlaan is following 20 prominent accounts