Statistical Genetics Unit at Pasteur Paris

🧬 New multi-trait genetic paper on asthma heterogeneity from Emmanuelle Bouzigon's lab and lead by Raphaël Vernet in the Journal of Allergy and Clinical Immunology

Unraveling shared genetics across asthma subtypes and 81 asthma-related traits

🔗 doi.org/10.1016/j.ja...

Unraveling shared genetics across asthma subtypes and 81 asthma-related traits Asthma is a complex and heterogeneous disease with a large spectrum of clinical and biological expressions reflecting the multiple underlying pathophysiologic mechanisms. It can be divided into subtyp...

A new collaborative work with our colleagues from HealthFex! Unraveling shared genetics across asthma subtypes and 81 asthma-related traits - www.jacionline.org/article/S009...

📰Journal club
Our team discussed “Leveraging the local genetic structure for trans-ancestry association mapping” (Xiao et al., AJHG 2022), which introduces LOG-TRAM, a method that boosts statistical power in underrepresented populations by using local genetic architecture. doi.org/10.1016/j.aj...

Is peer-review dead? A scientist’s plea to fix a broken system - Healthy Debate Peer-review may not be over, but the era of exploitative, opaque and corporatized gatekeeping should be.

Peer review is not quite dead but it’s on life support and the current model of scientific publishing is a burning platform. healthydebate.ca/2025/06/topi...

📣 Latest from the lab: Performance of deep-learning-based approaches to improve polygenic scores www.nature.com/articles/s41...

Its thought deep learning will substantially improve PGS but the reality is MANY have tried but no/little gain has been seen so far. Here we report our negative results.

Polygenic risk score prediction accuracy convergence Polygenic risk prediction has the potential to transform the diagnosis, treatment, and prevention of many common human diseases. However, the timescale and breadth of this transformation is partly unk...

This long-shot paper aimed to assess whether common GWAS pipelines are reaching their limits for prediction purposes. The review process was lengthy and painful. We're curious to see how it will fly! All comments are welcome! www.cell.com/hgg-advances...

Nice! Add a special relatedness matrix for cross-chromosome correlations to estimate the extra heritability due to assortative mating. Much larger contribution for educational attainment than for fluid IQ.

www.nature.com/articles/s41...

Simultaneous estimation of bi-directional causal effects and heritable confounding from GWAS summary statistics Nature Communications - Mendelian Randomization approaches are being increasingly refined, but certain statistical limitations hinder their application to GWAS. Here, the authors propose a new...

For today's journal club, we discussed the LHC-MR (Latent Heritable Confounder MR, rdcu.be/emhYv) paper from @zkutalik.bsky.social group. The study propose a new method to model concordant horizontal pleitropy thus accounting for confounding effect.

Postdocs in Epidemiology or Statistical Genetics at The Pioneer Centre for SMARTbiomed - Vacancy at Aarhus University Vacancy at Department of Public Health - NCRR - National Centre for Register-based Research, Aarhus University

We're hiring Pioneer Fellow Postdocs!!

Join us at the Pioneer Centre for SMARTbiomed to develop innovative methods in epidemiology, biostatistics, and statistical genetics, working with big biomedical data.

international.au.dk/about/profil...

#StatGen #Epi #Postdoc #SMARTbiomed

Identifying chronic obstructive pulmonary disease subtypes using multi-trait genetics Chronic Obstructive Pulmonary Disease (COPD) has a broad spectrum of clinical characteristics. The aetiology of these differences is not well understo…

A new study from the lab in collaboration with Michael J Cho from BWH investigating COPD subtypes using multi-trait genetics!
www.sciencedirect.com/science/arti...

Glad to be part of this collaborative piece investigating how genetic effect changes with age!

iovs.arvojournals.org/article.aspx...

La Fondation des Treilles, un lieu virgilien pour les arts et la pensée Dans « un paysage du bout du monde » situé dans le Haut Var, la Fondation des Treilles est un lieu qui favorise le dialogue entre créateurs et chercheurs.

Thanks to Les Treilles Fondation (www.fondationdestreilles.com) for hosting us for a wonderful retreat to discuss causal inference in genetics with Charles Assad, Brielin Brown, @judithabk6.bsky.social, Anne Rovsing, Matti Pirinen,Marie Verbanck,Xiang Zhou,Chiara Sabatti, and Sriram Sankararaman...

Postdoctoral position in Statistical Genetics - Research JOB DESCRIPTION Applications are invited for a postdoctoral position at the Institut Pasteur within the Statistical Genetics unit of the department of Computational Biology. Our unit addresses methodo...

📢Our unit is opening a postdoc position! All candidates interested in working in the field of Statistical Genetics in the thriving Institut Pasteur Paris campus are welcome to apply !!!
For details please check here: research.pasteur.fr/en/job/postd...