Janet Deane's lab

Alphaherpesvirus pUL21 homologues use non-canonical motifs to compete with cellular adaptors for protein phosphatase 1 binding Protein phosphatase 1 (PP1) is a key regulator of cellular phosphorylation and its activity is regulated via binding to cellular regulatory proteins via conserved short linear motifs (SLiMs). The herp...

How does #herpes hijack a human phosphatase to promote virus replication? We have a new @biorxivpreprint.bsky.social preprint showing how #HSV and #VZV use a novel motif to compete with canonical cellular #PP1 adaptors.
www.biorxiv.org/content/10.1...
🧵👇

a man in a tuxedo is applauding in front of a crowd of people ALT: a man in a tuxedo is applauding in front of a crowd of people

Congratulations to primary authors Holly and @danielacl.bsky.social on their first first-author research papers. This work was a fun collaboration with @deanelab.bsky.social, and many thanks to @bsfcharity.bsky.social for funding.

An exciting opportunity to start an independent position as a research fellow in protozoan parasitology at Christ's College, Cambridge and the Department of Pathology:
www.jobs.cam.ac.uk/job/52020/

Józef Lewandowski and I have a JPIAMR-funded Postdoctoral position available.

We are seeking a candidate to study antibiotic interactions with bacterial membranes using MD Simulations.

The successful applicant will be part of a larger consortium of academic and industrial partners.

bit.ly/3TVs74O

New in from @deanelab.bsky.social www.nature.com/articles/s41...

And another one from the very busy @deanelab.bsky.social - this time PhD work from Alex Nicholson
www.cimr.cam.ac.uk/research-adv...

Thanks @pstansfeld.bsky.social for a fabulous collaboration!

Molecular Regulation and Physiological Role of 1 GOLPH3-mediated Golgi retention The Golgi complex serves as the central hub of the biosynthetic pathway, where anterograde and retrograde trafficking converge. How cargo and Golgi-resident proteins traverse this organelle has long b...

We , @lbm-epfl.bsky.social and @gisouvggoot.bsky.social #EPFL together with and tf Sean Munro and John Briggs have today released two complementary preprints on GOLPH3 mediated intra-Golgi recycling
#CellBiology #MembraneTrafficking
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...

Q for the hive-mind 🧠: What transfection reagents do people like for big constructs these days? (I am thinking #HSV encoding BACs, ~170 kb). We've recently had poor performance with Trans-IT LT1 and Lipofectamine 2000, our two go-tos. Target cells are U2OS. Suggestions or RTs greatly appreciated 🙏

Over 150 participants from 23 countries came to Varna, Bulgaria for the 2025 FEBS Special Meeting/13th ICC. Five days of outstanding science, networking, socializing, and community! We are grateful to all the sponsors and look forward to the next one!

Big congratulations Jenny!

Absolutely delighted and privileged to have been appointed as a new group leader at @thecimr.bsky.social this week. The Dickens lab will be up and running later this year, continuing to understand mechanisms of disease in genetic forms of pulmonary fibrosis.

Are you, or do you know, a sixth-former interested in biomedical research? We're holding an on-line event in July where you can find out about career paths from researchers at different stages of their career, hear about our research, and watch a demo of an experiment. Details here 👇

Summer Research Programme - Cancer Research UK Cambridge Institute Our Summer Research Programme aims to inspire bright and ambitious undergraduates to start their careers in cancer research.

Applications are now open to join our Summer Research Programme!

📍 Live in @corpuscambridge.bsky.social
🔍 Work in the lab
🚀 Start your research journey

Deadline: 21 April

www.cruk.cam.ac.uk/students/und...

A montage image of scientists working in labs ad microscope images of cells

Are you (or do you know) a sixth form student interested in the biomedical sciences? We're running an on-line event over three mornings 28th-30th July. Find out more and apply here: www.cimr.cam.ac.uk/reaching-res...

I couldn't agree more

doi.org/10.1073/pnas...