Xin Xiang

I had fun checking out the endomap site (endomap.hms.harvard.edu/network). Surprisingly, PRPF40A (pre-mRNA splicing, Huntingtin-interacting, Aspergillus homolog Prp40A involved in cytoplasmic dynein function) connects to axonemal dynein light intermediate chain polypeptide, which is interesting!

www.dha.mil/News/2025/05...
Very proud of my colleague @pskcellbio.bsky.social and her lab for this important work on the clearance of misfolded GPI-anchor proteins out of the ER (supported by the NIH)!

journals.plos.org/plosbiology/...

Thank you Ferdos!

Acyl-coA binding protein AcbdA regulates peroxisome hitchhiking on early endosomes Motor-driven transport on microtubules is critical for distributing organelles throughout the cell. Most commonly, organelle movement is mediated by cargo adaptors, proteins on the surface of an organ...

Preprint from our lab is out! We identified a peroxisome-localized acyl-coA binding protein AcbdA - that regulates peroxisome movement. www.biorxiv.org/content/10.1.... Congratulations to members of my lab and the Christensen lab
@christensenlab.bsky.social www.biorxiv.org/content/10.1...

Beautiful work! Aside from the motor cooperation theme, this paper shows an insightful structure of the FHF complex (initially isolated by Wade Harper lab at Harvard. Xu et al 2008 MBoC). The structure contains FTS, the C-terminal part of Hook3 and FHIP1B. What a journey! Congrats to Abid Ali et al!

Our lab at the NIH (Bethesda, MD) is looking for postdoctoral fellows to join our team studying the molecular mechanisms of protein trafficking and their links to neurodevelopmental disorders starting on or after 10-1-2025. Send your application to juan.bonifacino@nih.gov. Please share and repost!

Thank you so much Prasanna!

Happy to share this short spotlight piece kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F... published online by @cp-trendscellbio.bsky.social
for an interesting paper about an unexpected mechanism behind Kinesin-1-mediated meiotic spindle positioning in C. elegans @cp-cellreports.bsky.social

Wow! Congratulations!

LC8 moonlighting (most likely) in channels. Nice work!

An interesting read. Neil Gow just gave a fantastic talk at the #ecfg17 on fungal cell wall components- on mannose polymers that can either be a flag or a mask for different immune cells. The part on the malaria parasite is also fascinating.

Just learned about this amazing work! doi.org/10.1016/j.cub.2024.12.041

Today in #journalclub, we looked at this fantastic new method from the @doudna-lab.bsky.social in Nature Biotechnology! They show how CRISPR–Csm enables single-molecule live-cell imaging of endogenous RNAs. Super cool!
www.nature.com/articles/s41...

The actin module of endocytic internalization in Aspergillus nidulans: a critical role of the WISH/DIP/SPIN90 family protein Dip1 Using FPs fused with actin or its fiduciary probes Lifeact, Chromobody and Tractin, we studied, by time-resolved microscopy, the actin module of endocytosis in Aspergillus nidulans. F-actin probes eff...

our first serious attempt to understand F-actin (F standing for filamentous, among other things) in Aspergillus nidulans: www.biorxiv.org/content/10.1...

Fungal impacts on Earth’s ecosystems - Nature This Review delves into the fungal kingdom, exploring the relationships among fungi, animals, plants and the environment, and investigating both the threats posed by fungi and their potential benefits...

Review in Nature

Case et al.
Fungal impacts on Earth’s ecosystems

www.nature.com/articles/s41...

Interesting! I guess they may still have it to get rid of lactic acid produced in muscle.

I am excited for this opportunity to chair the Department of Biochemistry and Biophysics at Weill Cornell Medicine! news.weill.cornell.edu/news/2025/01...

Integrating cell and planetary scales to address climate resilience The climate crisis is a multiscale problem that requires transdisciplinary expertise for understanding and engineering climate resilience. Cells are the first responders of the biosphere and yet cell…

The deadline to attend the “Integrating cell and planetary scales to address climate resilience” EMBO meeting is Feb 1st! We are bringing together scientists, funders, and policy makers. Join us for this exciting meeting: meetings.embo.org/event/25-cli...

This is such a sad news! I remember talking to him at meetings many years ago and learning about the Rab11-centrosome connection…

Graphical abstract of the Organelle Profiling paper, showing the workflow: Endogenously tagged organelle library; Native IP proteomics; Data-driven graph clustering; resulting in a subcellular proteome map with more than 7,600 proteins localized across 19 subcellular compartments.

Time to share our organelle proteome paper
out in @cellcellpress.bsky.social: doi.org/nzwz
We created a spatial map of human cells using organelle immunoprecipitation at scale.
Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/

1/3 🧪

I'm looking to database organelle dyes which work in fungi. Please comment if you can contribute w/ details.

We regularly see @mrccmm.bsky.social that some don't work in some fungi, but I just don't think it's been tested properly #Mycoscopy

I started this w/ Alex Lichius years ago, tip of the 🧊!

fusions in Aspergillus nidulans from different labs: Sec63-mRFP or Sec63-GFP labeling ER (Peñalva); GFP-RabE(Rab11) labeling post-Golgi vesicles (Peñalva); An-Nup49-GFP (and more) for nuclear pores (Osmani); PexK-GFP for peroxisomes (Hynes; Reck-Peterson) etc.

Best way to start 2025! Thrilled to share our Nature paper about the structures of axonemal components from sperm flagella and from epithelial cilia of the oviduct and brain ventricles. Great collaboration with Tzviya Zeev-Ben-Mordehai and @alanbrownhms.bsky.social

www.nature.com/articles/s41...

This is an great opportunity. Andrew, his science, and his team are amazing!

A very cool study revealing an important role of Fragile X messenger ribonucleoprotein (FMRP) in the local translation of a mitochondrial fission protein near its site of action. It really enhanced the understanding of the disease mechanism of Fragile X syndrome. Congratulations to all authors!

My family don’t want me to mix my love of fungi with the decoration of the family Christmas tree. ….. But I’m allowed my own one! @mrccmm.bsky.social

We have a very cool (I know I am biased😁) project for a computational biologist (postdoc) interested in cancer evolution in collaboration with Nicky McGranahan’s lab! Perfect opportunity to expand your computational skills too!
👉 www.godinholab.com
RT please 🙏🙏🙏👍👍

my first post in this network will be to honor Archibald Garrod, one of the forefathers (arguably the most ignored) of modern genetics.

A wonderful read and deeply inspiring! I am glad to have finally read it.

Excited to share the first published paper of my postdoc - a collaboration with Yildiz and Dumont groups led by Merve Aslan, on the fascinating dynein adaptor NuMA. Lots of super cool insights on how NuMA can activate dynein during mitosis. Thanks to @carter-lab.bsky.social for the support!