Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now?
www.nature.com/articles/s41...
More functional data, many thousands of words removed, and a few other updates from last year's preprint.
It was a pleasure to write the review on the role of phase separation in transcription together with you, @bsabari.bsky.social, Mikayla and Ambuja. I learnt a lot!
07.02.2026 04:00 — 👍 17 🔁 2 💬 1 📌 1Faculty retreat of @stjuderesearch.bsky.social today. We see evidence everywhere of how Jim Downing shaped the vision for St. Jude over the last twenty years. The results are cutting edge fundamental science, St. Jude Global and important new initiatives. Inspiring!
06.02.2026 17:43 — 👍 6 🔁 0 💬 0 📌 0
New preprint with work led by @asrauh.bsky.social in which we explore how double mutant cycles could be used to study molecular interactions in condensates, and highlight difficulties in extracting information about interactions from mutational experiments
www.biorxiv.org/content/10.6...
Graphical abstract of pre-print
Does targeting enzymes and substrates in a condensate lead to rate enhancement? No. Here, we investigate how the condensate environment can inhibit an enzyme reaction.
Spoiler: Mass-transport limitations. We find a strong correlation between diffusion and reaction rates.
doi.org/10.64898/202...
I am recruiting postdoctoral fellows to develop new research directions in the lab. We study transcriptional regulation through biomolecular condensates in development and disease, with an emphasis on first-principles and mechanistic discovery. Please repost or share with colleagues.
23.01.2026 18:35 — 👍 17 🔁 19 💬 1 📌 0
Second preprint of the year in which @sarahgersing.bsky.social from @rhp-lab.bsky.social mapped the effects of >7500 variants in glucokinase (GCK) on the interaction with the glucokinase regulatory protein so that we now have a 3D GCK scan (abundance, interaction, activity)
doi.org/10.64898/202...
Are you a junior scientist working in theoretical biophysics? @zamakany.bsky.social and I are organizing another workshop this fall here at @hhmijanelia.bsky.social. Travel and the workshop expenses are all covered!
tinyurl.com/yc66fawc
Seminar titles: Andrea Soranno (Single molecule spectroscopy of disordered regions and nucleic acids) and Bokai Zhu (Nuclear speckle rejuvenation to ameliorate proteinopathy).
IDPSeminars is BACK THIS WEEK!
Talks from Andrea Soranno and @bokaizhulab.bsky.social on Thursday! 1 pm EST / 7 PM European time!
Sign up here: forms.gle/3yCHeYvuuqLh...
And check out the full Spring 2026 schedule at idpseminars.com!
Nuclear speckle associated RRM-containing proteins are block copolymers. They make size-limited, ordered microphases, tens of nm in size comprising tens of molecules. Speckles are likely clusters or emulsions of distinct microphases and not macrophases www.sciencedirect.com/science/arti...
19.12.2025 19:14 — 👍 22 🔁 7 💬 1 📌 0
🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle.
Led by superb PhD student Carol Gao.
www.biorxiv.org/content/10.1...
Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
Hey that’s us 🎉
10.12.2025 22:34 — 👍 19 🔁 4 💬 1 📌 0
Our review on Integrative modelling of biomolecular dynamics 💃 is now live at COSB
We discuss approaches to integrate computational methods with time-dependent & time-resolved experiments to study protein dynamics
With @dariagusew.bsky.social & Carl G. Henning Hansen
doi.org/10.1016/j.sb...
Iowa State Dept of Molecular Biology is hiring for biomolecular solution NMR facility staff #NMRchat #Chemjobs #Chemsky
(I am NOT the hiring manager for this position, but I will refer any questions you have to the appropriate person.) isu.wd1.myworkdayjobs.com/IowaStateJob...
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
19.11.2025 21:16 — 👍 121 🔁 42 💬 4 📌 3Help me spread the word about an opening for the Furino Chair in Bioengineering in the Department of Bioengineering at McGill University. We seek candidates focused on developing biotherapeutic approaches to cancer, including but not limited to mRNA vaccines, CAR-T, and immunotherapy. (1/3)
12.11.2025 18:05 — 👍 5 🔁 6 💬 2 📌 0Re-boosting! The Dept. of Microbiology 🧫 at the University of Tennessee is hiring two 9-month faculty! Come join a vibrant and growing department located in the foothills of the Smoky Mountains! #microsky
06.11.2025 13:07 — 👍 8 🔁 16 💬 0 📌 0
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
31.10.2025 09:24 — 👍 27 🔁 43 💬 0 📌 3
We (@sobuelow.bsky.social) developed AF-CALVADOS to integrate AlphaFold and CALVADOS to simulate flexible multidomain proteins at scale
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost!
apply.interfolio.com/174756
Image of Toronto
JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
www.nature.com/naturecareer...
Please repost!
🚨The 2026 IDP GRC Program is LIVE! 📣
Check it out: www.grc.org/intrinsicall...
We’ve got an incredible speaker lineup! 🌟
Over the next few weeks, we’ll be highlighting some of them and giving you a sneak peek at the exciting topics they’ll be covering. Stay tuned!
Open Faculty Position: Assistant or Associate (Untenured) Professor Application deadline: 11:55 PM on Wednesday, October 15, 2025 Sarafan ChEM-H is seeking candidates with research programs that exist at the interface between molecular science and computation. Click the link above to learn more & apply!
Open faculty position!
We're seeking applicants for a tenure-track faculty position at the junior level (Assistant or untenured Associate Professor) with research programs that exist at the interface between molecular science and computation. Apply here: stanford.io/45MF3Qa
🚨🚨The GRC on Intrinsically Disordered Proteins #IDPs is back!! 🍝🧵🏔️Join us for cutting-edge IDP science, great discussions, and mountain views 🌄🍝
📅 June 21-26, 2026 | Les Diablerets, Switzerland
👉 Details & registration: grc.org/intrinsicall...
It’s actually all your own doing, Alex. Very well deserved.
02.10.2025 19:36 — 👍 1 🔁 0 💬 0 📌 0
Why are transcription factors disordered? Come join us in Oxford as a postdoc and we'll find out together!
Help publish 3 mature projects, AND develop cool new single molecule fluorescence binding assays!
biophysics
transcription
protein:DNA interactions
my.corehr.com/pls/uoxrecru...
Come work with me. Excellent startup package. su.varbi.com/en/what:job/...
30.09.2025 07:43 — 👍 4 🔁 4 💬 0 📌 0Congratulations, Alex!!
30.09.2025 05:42 — 👍 2 🔁 0 💬 1 📌 0
We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22.
biochem.weill.cornell.edu/join-our-fac...
We are looking for a new colleague to join the vibrant and fast-growing biophysics community at CMU and in Pittsburgh! The City of Bridges also offers a unique combination of affordability, innovative ecosystems, and rich cultures. Please spread the word!
29.09.2025 21:10 — 👍 4 🔁 3 💬 0 📌 0
