Transgene-free generation of mouse post-gastrulation whole embryo models solely from naive ESCs and iPSCs Hanna and colleagues show that signaling pathway modulation amplifies the inherent flexibility of genetically unmodified mouse naive PSCs to adopt extra-embryonic cell fate potential. This endows them...

1/n Fun journey continues: Our new @cp-cellstemcell.bsky.social paper out on how the Inherent & Dormant Plasticity of Mouse Naive PSCs can be "Exaggerated" to Directly form ~E8.5 Transgene-Free (TF) Mouse SEMs & WITHOUT inducing 8-16-Morula-like "Embryo Founder Cells".

www.cell.com/cell-stem-ce...

Honored to receive the @isrbio.bsky.social Rising Star Award for our work in regeneration biology! Grateful to the committee and our colleagues for the recognition. A huge motivation for the lab. Excited to give the award talk in Madison next week and connect with everyone! 😎🥳🍾 shorturl.at/LnkSt

Mechanochemical coupling of cell shape and organ function optimizes heart size and contractile efficiency in zebrafish Andrews et al. demonstrate that multiscale feedback between mechanical and chemical cues builds a functional heart to support zebrafish embryonic life. Cell recruitment and organ-scale forces drive tr...

Thrilled to bits to see our latest work online in Dev Cell! 🥳

We wanted to know how cells build functional organs with precision🫀🫁📏 Here we show how coupling of cell shape and organ function fine tunes the form and contractile power of the developing #zebrafish heart 1/n

tinyurl.com/cell-stretch

Grateful and excited to launch the Otsuki Regeneration Group at the Hubrecht Institute!
🔗 www.hubrecht.eu/research-gro...

We study how tissues regenerate - and use those principles to build 3D tissues in vitro.

Full announcement: www.linkedin.com/in/leo-otsuk...

@hubrechtinstitute.bsky.social

Thrilled to see our revised preprint now published in Nature Ecology & Evolution!
If you’re curious about how to build a bat wing by re-using existing gene programs, check out the link or the tutorial below. Big congratulations to all co-authors!! Thanks to reviewers!

www.nature.com/articles/s41...

This Sp9 staining ROCs 😍
(Pun very much intended — for 🐸 regen aficionados.)

🧪 Job alert 🔊 we are hiring a Research Assistant - join the Simões Group at DPAG-IDRM @ox.ac.uk supporting #cardiovascular development and regeneration research, working with #zebrafish and #human stem cell systems: my.corehr.com/pls/uoxrecru... @oxforddpag.bsky.social @idrm.ox.ac.uk (1/4)

Pls spread the word! We have a postdoc position available in the Rocha Lab @mpi-muenster.bsky.social. Join our team to study mechanisms underlying robust organ development using zebrafish embryos and human organoids.

mpi-muenster.mpg.de/career

Do you like developing new AI vision methods for microscopy image analysis? You love theory & implementation? 1 week left to apply for a fully funded PhD position in our lab in Dresden 🇩🇪! Topics: object detection/tracking, multimodal models & more. DM/email for details! #PhD #AcademicJobs #GPUsgoBrr

Schematics depicting the dorsal and ventral sides of fins and limbs

We take for granted that our hands have two sides and can articulate in an endless number of ways. But what about a fish’s fin? Can a fish know something “like the back of its fin,” or have its future told with a fin palm reading? Check out this bluetorial to find out 👇🧪🧬🐟 doi.org/10.1101/2025...

Morphodynamics of human early brain organoid development - Nature Human brain morphodynamics are explored using organoids.

Very happy to share it’s online! If you read the preprint, updates include tracking cells and tissue flow, Histo4i timecourse (69 Abs) comparing spatial patterning emergence and a new WLS KO ipsc line establishing mechanosensing via YAP-WLS/WNT caudalizes organoids www.nature.com/articles/s41...

⚠️ I am really excited to share the work of Anastasios Balaskas, an excellent PhD candidate in the lab, with the wider world. Tasos made a significant advance: generating a stem cell-based embryo model that contains both posterior and anterior neural tissues of the late-stage gastrulating embryo.

Mechanisms of regeneration: to what extent do they recapitulate development? Summary: By comparing regeneration and development, this Review highlights new insights into morphogenesis, revealing potential non-developmental strategies for tissue regrowth.

You might not have heard of the three-banded panther worm, but it's Mansi Srivastava's animal of choice for understanding the extent to which embryonic development & regeneration share common mechanisms

#2025ICDB #2025SDB #ICDB2025

Related @dev-journal.bsky.social Review by @canaztekin.bsky.social

@canaztekin.bsky.social @bacell3d.bsky.social presents his work on oxygen sensitivity and the evolution of limb regeneration ! Air liquid interphase cultures to study regeneration in vitro

Huge congrats 🥳

Out today in @natmethods.nature.com : Spotiflow, our transcript localization method for imaging-based spatial transcriptomics. Led by amazing PhD student @albertdm.bsky.social, joint work w @gioelelamanno.bsky.social at EPFL / @scadsai.bsky.social
www.nature.com/articles/s41...
rdcu.be/epIB7

Omaya Dudin Interview with Omaya Dudin, who uses Ichthyosporea as models to study how and why unicellular organisms evolved multicellularity at the University of Geneva.

90% of you probably don’t need to read this.
But maybe some of you are curious & 10% will feel seen. Or a little less alone. This isn’t about seeking sympathy.
It’s about sharing something hard to say out loud;
partly to heal, partly in case someone needs to hear it too. (1/3)
tinyurl.com/DudinO

🚨 theory/math devbio preprint alert!!! 🚨

Led by my v. talented PhD student, Daniel Muzatko, we’ve found some rather general and intriguing constraints on reaction-diffusion systems that allow them to self-organize developmental patterns:

www.biorxiv.org/content/10.1...

Conservation of regulatory elements with highly diverged sequences across large evolutionary distances Nature Genetics - Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence...

How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...

Near-infrared spatiotemporal color vision in humans enabled by upconversion contact lenses Based on the principle of refractive index matching, highly transparent upconversion contact lenses (UCLs) with a high concentration of upconversion nanoparticles (UCNPs) were developed. These lenses efficiently convert multispectral near-infrared (NIR) light into the three primary visible colors, enabling humans to acquire wearable NIR color vision.

Now online! Near-infrared spatiotemporal color vision in humans enabled by upconversion contact lenses

Delighted that our work on positional memory is now published. We asked how axolotl cells 'know' which part of the limb to regenerate after injury.
www.nature.com/articles/s41...
A joy to work with super team Sarah Plattner, Yuka Sugiura, Francisco Falcon and Elly Tanaka.
🧵1/14

Congrats, Prayag! 🥳 🎉

Pre-print alert:
This is our latest work on limb regeneration. We found that connective-tissue (CT) cells are necessary for this process by using a combinatorial approach of #spatial transcriptomics and an #ablation system for the first time in the #axolotl!
👇🧵1/6
www.biorxiv.org/content/10.1...

Thrilled to announce that I am looking for a Research Technician/Assistant to join my lab @imbavienna.bsky.social. Please consider applying if you’re enthusiastic about #devbio #stemcells #teamwork and excited to help shaping a new lab!

Thankful for any retweet! 🫶

imba.onlyfy.jobs/job/l6u2m980

A computational pipeline for spatial mechano-transcriptomics - Nature Methods The authors present a computational framework that leverages mechanical force inference and spatial transcriptomics to enable analyses of the interplay between the transcriptomic and mechanical state.

🚨 Paper Alert 🚨
Absolutely delighted to share our last paper on "spatial mechano-transcriptomics" @naturemethods👇!!
www.nature.com/articles/s41...

Super cool dataset- (additionally) excited to see the hif1a data in Polypterus! more to discover about the evolutionary roots of reduced oxygen sensing in regenerating animals! :) congrats @ischneider.bsky.social and all the other authors

Measuring and manipulating mechanical forces during development - Nature Cell Biology This Review discusses the recent advances in experimental approaches to interrogate the mechanical forces that mediate tissue deformations during development, highlighting the insights afforded at bot...

Happy to share our review on methodology for measuring and manipulating mechanical forces with specific focus on developmental biology! Congrats to authors @clemvilleneuve.bsky.social @mccreery.bsky.social and hats off to the community for developing awesome tools www.nature.com/articles/s41...

📢 We are hiring! 📢

We are looking for a postdoc to help us work out why mice cannot regenerate the spinal cord but spiny mice *can*.

More info and how to apply: tinyurl.com/4m6yzbef

Get in touch if interested!

Congratulations, Kristina!!! :)

🥂😎