Excited to share our new review in @dev-journal.bsky.social on tissue phase transitions during development!
@karengrace12.bsky.social @nicolettapetridou.bsky.social
🔗 doi.org/10.1242/dev....
Excited to share our new review in @dev-journal.bsky.social on tissue phase transitions during development!
@karengrace12.bsky.social @nicolettapetridou.bsky.social
🔗 doi.org/10.1242/dev....
We summarised the many roles of material phase transitions in development (and they are not just mechanical 🤔)
19.02.2026 14:07 — 👍 30 🔁 9 💬 0 📌 0Amazing and so well deserved! 🥳🥳
19.02.2026 17:13 — 👍 1 🔁 0 💬 1 📌 0
I’m thrilled to share that I will join @gustaveroussy.fr as a Group Leader!
Our objective: to understand how mechanochemical feedbacks regulate tumor dynamics and plasticity, with the overarching goal of bridging tissue mechanobiology and tumor pathophysiology using human organoids.
Best possible lab for a PhD / postdoc! Stay tuned for future openings and wonderful science.
18.02.2026 20:44 — 👍 12 🔁 3 💬 1 📌 0From models to molecules: self-organized and instructed modes of developmental patterning www.nature.com/articles/s41... - nice piece by @davidbrueckner.bsky.social
19.02.2026 07:38 — 👍 21 🔁 7 💬 0 📌 0
After being reviewed as a preprint in Elife our paper about endogenous FGF signaling in 2D human gastruloids is now published in Development:
journals.biologists.com/dev/article-...
In a really fun collaboration with Max Wilson’s lab at UCSB, we’ve developed a simple model that can capture the non-monotonic expression of Wnt target genes with respect to frequency in periodic (optogenetic) Wnt pulses: elifesciences.org/articles/107.... Great work Sam, Olivier, Naomi and Ryan :)
30.01.2026 18:32 — 👍 11 🔁 3 💬 0 📌 0
New preprint! We show how mesoscopic nonequilibrium fluctuations in active gels emerge from the breaking of detailed balance at the molecular scale. Warning: Long technical paper ahead! Enjoy! @mpipks.bsky.social @ub.edu @ubics.bsky.social @icreacommunity.bsky.social
arxiv.org/abs/2601.20483
Our latest: A gene selection method for single-cell RNA-seq that identifies developmental & spatial patterns missed by other analysis pipelines
ESFS: A Noise-Resilient Framework for Feature Selection and Marker Gene Discovery in Single-Cell Transcriptomics | bioRxiv www.biorxiv.org/content/10.6...
Our review on Marr's levels in embryonic development is now out in @prxlife.bsky.social !
journals.aps.org/prxlife/abst...
Visiting @hhmijanelia.bsky.social just before the winter storm hits! So much awesome science here!
23.01.2026 13:11 — 👍 1 🔁 0 💬 0 📌 0
Prof. Fiona Doetsch has been awarded the 2026 Louis-Jeantet Prize for Medicine!
Her discoveries reveal how neural stem cells support lifelong brain plasticity and repair. 🧠
Read more: www.biozentrum.unibas.ch/news/detail/...
Welcome to Basel @robinjournot.bsky.social !! :)
14.01.2026 16:35 — 👍 1 🔁 0 💬 0 📌 0
My time at @institutcurie.bsky.social is done! Over the past months, I completed my PhD, published my first first-author paper in DevCell (www.cell.com/developmenta..., and submitted my first last-author manuscript to bioRxiv (www.biorxiv.org/content/10.1...).
14.01.2026 15:47 — 👍 6 🔁 2 💬 1 📌 0
Feb 1 deadline approaching for our @kitp-ucsb.bsky.social QBio summer course on Physical Principles of Morphogenesis in Plants and Animals. @streichan.bsky.social
@maurazimmermann.bsky.social @maizel-lab.org @yusuke-mori.bsky.social @akankshi.bsky.social @nicolettapetridou.bsky.social
Interested in the biophysics of organoids? We just published a review in Dev Cell—take a look! dlvr.it/TPyTb8 #Organoids #Biophysics
06.01.2026 10:27 — 👍 81 🔁 26 💬 0 📌 2
Self-organized or instructed?
My @natrevgenet.nature.com Journal Club traces how classic papers revealed two modes of developmental patterning & why the debate between Turing and Wolpert is as timely as ever for organoid engineering today
www.nature.com/articles/s41...
And here is the PDF of the 4th course @college-de-france.fr. You will find the justification and presentation of geometric representation of cell decisions, a parsimonious mathematical model for signalling and cell state transitions
tinyurl.com/yc7u296j
Here is the link to download the PDF of my course#5 on Biological computation. I present & discuss Self-tuning, Adaptation and Learning in biological (non-neuronal) systems, in particular during embryonic development.
This course contains various personal ideas/proposals.
tinyurl.com/hcpwsbtm
Please find below the link to watch the VIDEO of my course#5 @college-de-france.fr on Biological computation. I present and discuss Self-tuning, Adaptation and Learning in biological (non/neuronal) systems, in particular during embryonic development.
Enjoy!
tinyurl.com/4pv95an9
Super nice to see this awesome set of lectures online! A really timely perspective on biology through the lens of information, which inspires much of our own research as well.
05.01.2026 08:34 — 👍 10 🔁 2 💬 0 📌 0
Munro, E., Nance, J., & Priess, J. R. (2004). Cortical flows powered by asymmetrical contraction transport PAR proteins to establish and maintain anterior-posterior polarity in the early C. elegans embryo. Developmental cell, #EpithelialMechanics www.sciencedirect.com/science/arti...
05.01.2026 08:00 — 👍 6 🔁 1 💬 0 📌 0This was a fun theory collaboration led by amazing postdoc Alex Zhang, in collab with Gasper Tkacik (ISTA)
05.01.2026 08:00 — 👍 0 🔁 0 💬 0 📌 0
Throughout this work, we found it really helpful to organize our thinking along 'Marr's three levels of analysis':
1. the computational problem
2. the algorithmic solution
3. biophysical implementation
Check out our review laying out this conceptual framework here: buff.ly/NE4JEOA
Remarkably, these optimal algorithms predicted by our theory are almost perfectly matched by minimalistic mechanistic models, including averaging through short-range diffusion and divisive normalization through a fast diffusing 'normalizer' species
05.01.2026 08:00 — 👍 0 🔁 0 💬 1 📌 0
Spatially uncorrelated noise: it's best to spatially average the input you get from the neighbors
Long-range correlated noise: it's best to perform a divisive normalization - normalize your measured value by that of your neighbors
Complex things happen in between these limits...
Here, we ask how CI can be useful to single cell decision making, by predicting the additional PI gained when cells interact with their neighbors.
Depending on the spatial correlations of the input pattern, completely different strategies to communication are required to gain information
In our recent paper on self-organized patterning, we demonstrated how the total information of a pattern is composed of positional (PI) and correlational information (CI).
While PI measures local accuracy, CI is determined by the spatial correlations of a pattern.
www.pnas.org/doi/10.1073/...
How can cells use information from neighboring cells to improve the spatial precision of morphogen patterns? 🤔
We show that cells can gain positional information by "talking" to their neighbors - how much depends critically on spatial correlations of the patterns.
buff.ly/w56OUJT