St. Jude Research

This discovery clarifies how disruptions in stress granule regulation can contribute to conditions such as multisystem proteinopathy, amyotrophic lateral sclerosis and frontotemporal dementia, highlighting potential therapeutic targets.

Protein sidekick exhibits dual roles in stress granule assembly and disassembly See how St. Jude researchers reveal how ASPL and VCP control stress granule assembly and disassembly, shedding light on neurodegenerative disease mechanisms.

New findings reveal that the ASPL protein plays distinct roles in both the assembly and disassembly of stress granules—mechanisms linked to neurodegenerative diseases. ow.ly/lCP550X8H3J

This discovery clarifies how disruptions in stress granule regulation can contribute to conditions such as multisystem proteinopathy, amyotrophic lateral sclerosis and frontotemporal dementia, highlighting potential therapeutic targets

St. Jude is advancing therapies such as immunotherapy and precision medicine while expanding global access to care through collaborations with WHO, UNICEF and others.

"To be named among the top children’s cancer hospitals every year since the rankings began is a reflection of our people—their brilliance, their heart and their unwavering commitment to our mission,” said James R. Downing, MD, president and CEO.

St. Jude Children’s Research Hospital has been ranked among the top 10
pediatric cancer hospitals by U.S. News & World Report for the 18th year in a row.

Read more: ow.ly/HNLN50X7PsR

Alongside wellness programs, growth opportunities and more, our new childcare center sets us apart in our support of our staff’s well-being. “The center was near full subscription not long after opening,” said Maria Megdal, EVP and chief administrative officer.

Proud to be ranked No. 2 on the @Forbes list of Best Employers for Healthcare Professionals! At St. Jude, we invest in our team so they can focus on our lifesaving mission.

ow.ly/HPal50X6mBj

The application deadline for the 2026 CCSS Ann C. Mertens Career Development Award has been extended through Monday, November 3.

This is a great opportunity for early-career investigators and trainees interested in childhood cancer survivorship research. Learn more: ow.ly/GOzN50WCMpP

“These methods are now being used by other labs to study important processes in the brain in ways that haven’t been done before,” said @lindsayschwarz.bsky.social, PhD. As technology continues to evolve, St. Jude researchers are lighting the way to new knowledge.

Innovations include self-healing fluorophores for more precise imaging, an intersectional genetic platform to label rare neuronal populations and the first visualization of cytonemes in mammalian tissue. All discoveries are driven by advances in fluorescence and microscopy.

A gloved hand adjusts a component inside a complex scientific instrument. Text on image reads "Scientific Report 2025" titled Lighting the Way to Knowledge, with the subtitle Translating Science Into Survival. The St. Jude logo appears in the top right corner.

St. Jude researchers are advancing science by harnessing light-based technologies to explore the molecular and cellular mechanisms underlying health and disease. ow.ly/3TEI50X4nsQ

The Global Platform in Action: How Country-Led Collaboration is Strengthening Access to Childhood Cancer Medicines In this upcoming Stakeholder Engagement Dialogue, we offer a unique look into the preparations made by participating countries to achieve readiness through multisectoral collaboration and collective a...

The work continues. Register to join us at our October stakeholder engagement webinar to keep building hope and better outcomes for kids everywhere. ow.ly/3KSv50X4nfh

#GlobalHealth #UNGA

This event showed the power of collaboration, sharing best practices, fostering new partnerships, & driving action for sickle cell disease and childhood cancer. The convening power of St. Jude brings leaders together to build lasting, resilient health systems for all children.

At #UNGA80, St. Jude & Uzbekistan co-hosted a landmark side event, united by Bente Mikkelsen’s leadership, 8 first ladies, WHO DG @DrTedros & ministers of health worldwide. Together, we’re advancing global health for children facing catastrophic diseases.

If successful, this technology could improve the accuracy of infection diagnosis, reduce unnecessary procedures and advance care for patients with sickle cell disease. Future trials will focus on its application in clinical settings.

“[18F]fluoromannitol’s ability to accumulate only in bacteria indicated it to be a sensitive bacterial imaging agent worthy of further investigation,” said Kiel Neumann, PhD.

Two scientists in lab coats examining a wired device in a laboratory. Text on image reads: 'New radiotracer for infection detection enters first in-human clinical trial.'" The St. Jude child logo is above the text.

A novel radiotracer, [18F]fluoromannitol, is now entering a first-in-human clinical trial at St. Jude. This PET/CT imaging agent could help clinicians distinguish between disease-related inflammation and bacterial infection in patients with sickle cell disease. ow.ly/PV9u50X3PJn

“Achieving exceptional status for the third consecutive time is a testament to the work of our faculty and staff members, and the impact this Center has on pediatric cancer research and treatment,” said Charles Roberts, MD, PhD.

We have received our third consecutive exceptional rating from the National Cancer Institute as a Comprehensive Cancer Center, the highest distinction awarded. St. Jude remains the only center of its kind devoted solely to children.

Learn more: ow.ly/GPA350X3P3X

“Achieving exceptional status for the third consecutive time is a testament to the work of our faculty and staff members, and the impact this Center has on pediatric cancer research and treatment,” said Charles Roberts, MD, PhD.

Unpasteurized H5N1-infected milk remains a health concern, but pre-existing immunity from seasonal flu provided full protection. Current food safety and vaccination practices are likely effective.

Person in a bright pink blazer standing in a hallway. Text overlay reads: Pasteurized milk with H5N1 viral components does not impact flu immunity. St. Jude Children's Research Hospital logo in the corner.

New study reveals pasteurized milk containing H5N1 influenza viral components poses minimal health risks and doesn’t alter influenza immunity. Regularly drinking contaminated pasteurized milk doesn’t increase flu susceptibility in model systems. ow.ly/stPC50X32eB

Aligning data on diagnosis is a priority supported by the Cancer Classifications for Kids portal from St. Jude Cloud. “Cancer type and subtype are probably the most fundamental lens through which we look at cancer, both in the clinic and the research setting,” said Michael Rusch.

The API enables researchers to query harmonized data across platforms, streamlining access and analysis. "The API catalogs and allows user exploration of pediatric cancer research data contained within the federated data ecosystem—institutions across the US," said Clay McLeod.

Quote from Clay McLeod, Director of Product Development & Engineering at St. Jude Cloud, overlaid on a digital illustration of a cloud with interconnected lines and nodes symbolizing data sharing. The quote highlights the impact of the CCDI Federation API in enabling real-time access to research data across the U.S.

St. Jude is a proud partner in the National Cancer Institute’s Childhood Cancer Data Initiative (CCDI) Federation API, which recently celebrated its first anniversary. This Childhood Cancer Awareness Month we highlight this important contribution.

By screening thousands of CAST variants, St. Jude researchers engineered a system with a fivefold increase in activity and minimal loss of targeting specificity. These findings offer new insights for clinical genome-editing applications.

Screening approach enhances CRISPR genome-editing efficiency See how thousands of genome-editing CRISPR transposons were screened rapidly for efficiency highlighting route for bioengineering strategies

Scientists have developed a high-throughput screening approach to optimize bacterial CRISPR-associated transposons (CASTs) for genome editing in human cells. This method enabled rapid detection of CAST mutants with improved efficiency and specificity. ow.ly/Skwy50X1eus

Amazing - congratulations on 22 years, @miriamdillard.bsky.social!

Collaboration accelerates innovation and expands access to care for children worldwide. Join our virtual side event Wednesday at 1:15 p.m. ET to learn more: ow.ly/W5rt50X1b3p

#UNGA80