Thrilled to share the second half of my PhD work here!
We show how data on expression quantitative trait loci (eQTL) relates to the structure of gene regulatory networks (GRN). Much of the GRN / eQTL picture is unmapped, but what we do have says a lot⦠(1/)
doi.org/10.1101/2025...
22.08.2025 19:50 β π 69 π 25 π¬ 6 π 1
I'm excited to announce that I'll be starting a lab at UCSF in the @ihgatucsf.bsky.social and @ucsf-epibiostat.bsky.social in July.
We'll work at the intersection of statistical genetics, population genetics, and machine learning.
02.06.2025 17:45 β π 143 π 24 π¬ 32 π 1
I have an opportunity to hire a staff scientist for my lab. Looking for someone with outstanding skillset in ML/statistics, genomics applications; interest in mentoring, strong publication record, PD experience required.
Email CV to me+cc my assistant (see 'contact' on my website). Ad to follow.
01.06.2025 15:33 β π 83 π 108 π¬ 3 π 3
Japan can be a science heavyweight once more β if it rethinks funding
The nation must lose its tight focus on individual disciplines if it is to keep pace with the evolving requirements of scientific enquiry.
Japan can be a science heavyweight once more β if it rethinks funding
Research leaders call for an end to substantial underfunding of interdisciplinary research in Japan.
On my current visit to π―π΅ I can see the country is ready for a change
#japan #academicSky π§ͺ
www.nature.com/articles/d41...
12.02.2025 09:47 β π 50 π 16 π¬ 0 π 2
Thank you, Joseph! We greatly appreciate your contributions to the field and are grateful to have had the chance to work with your data!
28.01.2025 01:55 β π 1 π 0 π¬ 0 π 0
I posted a couple days ago about our new paper on building causal graphs from genetic associations + Perturb-seq.
Here I want to expand on the value of using DIRECTIONAL information contained in LoF burden tests.π§΅
[work led by @minetoota.bsky.social ]
bsky.app/profile/jkpr...
27.01.2025 19:18 β π 61 π 14 π¬ 1 π 1
Beautifully elegant work on integrating LoF, GWAS & Perturb-seq data to build causal paths from regulators to genes / programs to phenotype. And it didn't require a foundational virtual cell model (well almost ... gene & protein embeddings r used in GeneBayes)! π
26.01.2025 17:44 β π 39 π 6 π¬ 1 π 0
Great new study from @jkpritch.bsky.socialβs lab, led by @minetoota.bsky.social,
combining βquantitative estimates of gene-trait relationships from loss-of-function burden tests with gene-regulatory connections inferred from Perturb-seq experiments in relevant cell typesβ π
26.01.2025 08:43 β π 5 π 3 π¬ 0 π 0
@minetoota.bsky.social set the groundwork for many ongoing projects in @jkpritch.bsky.social and Marson lab. Great to see this out!
26.01.2025 19:29 β π 10 π 3 π¬ 0 π 0
Really nice work. And they chose one of my favorite traits to model: mean corpuscular hemoglobin.
Allows me to reuse one of my figures from a few weeks ago on a gene as old as eukaryotes, mitoferrin, which is needed to move iron into mitochondria.
@jkpritch.bsky.social
24.01.2025 11:18 β π 12 π 4 π¬ 1 π 0
Itβs been an incredibly exciting journey!
I am truly grateful to my mentors @jkpritch.bsky.social, Alex, and co-authors @jeffspence.bsky.social, @tkyzeng.bsky.social, @emmamarydann.bsky.social, as well as all the wonderful members of the Pritchard and Marson labs for their incredible support!
26.01.2025 01:40 β π 4 π 0 π¬ 0 π 0
Thank you Jonathan for these fantastic threads about our recent work!
We dove into how we can model the gene regulatory architecture of complex traits with 1) Gene effects from LoF burden tests and 2) Perturb-seq.
26.01.2025 01:35 β π 20 π 6 π¬ 1 π 0
Why do association studies prioritize trait-specific variants???
A quick thread about the importance of thinking about all traits at once π 1/6 (π§ͺπ§¬)
17.12.2024 07:04 β π 44 π 23 π¬ 2 π 3
Central control of dynamic gene circuits governs T cell rest and activation - Nature
Resting and activated T cell states are established by context-specific regulators and dynamic gene circuits.
Beautiful work led by Maya Arce from Marson lab reveals a fascinating story about rewiring of a critical gene regulatory circuit in different T cell types: T effectors and Tregs
www.nature.com/articles/s41...
11.12.2024 20:46 β π 41 π 11 π¬ 0 π 0
PhD student @UTokyo. Rheumatologist.
Incoming postdoc at Genentech | PhD from Stanford Biomedical Data Science.
Assistant Professor at Harvard MCB. T cell, Microbiome, and diet. ζ°Έε³Ά δΈζ¨Ή π―π΅πΊπΈ
Genome scientist becoming engineer. Immunologist. Geneticist. Dabbles in statistics and statistical learning. Home @UCSF, affiliated with Arc and PICI.
Pediatrician, Stanford DBDS PhD, and Knight-Hennessy scholar.
Neuroscience Professor at UKBonn&DZNE Bonn. Bridging the gap between brain and immunity with genomics π³οΈβππ΄ββ οΈπ¨π³πΉπ·π«π·π³πͺπ©πͺ
ORCID 0000-0001-6319-404X
PhD student w/ Benjamin Good and Dmitri Petrov at Stanford University interested in evolutionary dynamics & somatic evolution
alyulina.github.io
Researcher in bioinformatics working on single-cell data visualization
Scientist in the Trynka lab at the Wellcome Sanger Institute
Interested in all things related to T cells, CRISPR and imaging
Profile picture by Megan Gozzard
Research associate/assistant at IoPPN(@kingsioppn.bsky.social), KCL(@kingscollegelondon.bsky.social). Behavioural epidemiology, statistical genetics, factor analysis, machine learning.
Postdoc at @humantechnopole.bsky.social working with Andrea Sottoriva to study the evolutionary rules of cancer.
Previously at UW Genome Sciences and @irbbarcelona.org
π david.masponte.com
Computational Biology PhD student @ucberkeley
PhD AI for Drug Discovery @QMUL, @EPFL, @MSDintheUK. ex-{@TUDelft, @CureVacRNA}. Researching the intersection of AI and biology to improve human health. π§¬π€
Postdoc @uwgenome πΆ
PhD Genetics @uarizona π±
BA Chemistry @brynmawrcollege π¦
Population Genomics, Machine Learning, Cancer Evolution π§¬π»
πSeattle, WA & Vancouver, BC
https://www.linkedin.com/in/linhnhtran/
Aging lab @Stanford. Our interests include mechanisms of aging, brain aging and rejuvenation, neural stem cell aging, genetics of lifespan and suspended animation in killifish
Medical Doctor & Scientist | Data and evidence in medicine | Building @PheironInc | via @ChariteBerlin, @berlinnovation, @UniFAU
PhD, PI Immunogenetics: Immunogenomics/Autoimmunity/Rheumatology/Oncology/Bioinformatics.
Evolutionary biologist; postdoc @oistedu.bsky.social; evolutionary theories | complex traits | evolutionary novelties
Views are my own.
https://rexjiang385518549.wordpress.com/