Chris Greene

The vascular contribution to cognitive decline in ageing and dementia - Nature Reviews Neuroscience Growing evidence suggests that reduced cerebral blood flow contributes to cognitive decline in ageing and dementia. Attwell and colleagues discuss the underlying mechanisms and functional consequences...

Delighted to share our latest review in Nature Reviews Neuroscience!
We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies.
www.nature.com/articles/s41...

Frontiers | Walking on the tightrope: the shared roles of the bridging pericytes in the brain The vasculature of the central nervous system (CNS) is a highly specialized structure that delivers oxygen and nutrients to energy-demanding neural cells whi...

🚨 Review Alert

*Walking on the tightrope: the shared roles of the bridging pericytes in the brain*

Congratulations Audrey Chagnot!! 🥳

Bias aside, this feels like a really meaningful piece for the cerebrovascular field! 😊

www.frontiersin.org/journals/cel...

🚨 We’re hiring! FutureNeuro is looking for a StAR Lecturer to lead research in neuropsychiatry, neural engineering, or digital health. Join us at RCSI. Apply by August 29: www.linkedin.com/jobs/view/42...

@rcsi.bsky.social @rcsi-research.bsky.social

We are very excited to be hiring a Postdoc to our expanding team! Are you interested in neuroinflammation, immunometabolism and/or epilepsy research?? 🧠 Apply now my.corehr.com/pls/coreportal……
@Futureneuro_ie @RCSIPharmBioMol
***Closing date 16th July***

Enhanced retinal pigment epithelial cells as a delivery vehicle for retinal disease Age-related macular degeneration (AMD) is one of the leading causes of central retinal blindness. Here, Campbell and colleagues show that transplanted retinal pigment epithelial cells can be engineere...

New paper led by Avril Reddy in @mattcampbelltcd.bsky.social lab showing IPS derived human RPE cells expressing aflibercept and/or soluble CD59 can attenuate lesions in mouse model of age-related macular degeneration. Cool project to help out with. www.cell.com/molecular-th...

Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related systemic inflammation in COVID-19 - Nature Neuroscience The authors show that brain inflammation in COVID-19 correlates with viral load, systemic inflammation and virus-sensing pattern recognition receptors. Microglial dysfunction occurs at sites of vascul...

IL-1- and IL-6-related systemic inflammation in #COVID19 is associated with #microglia dysfunction, neurovascular inflammation, and focal neuropathologies 🧪🧠

www.nature.com/articles/s41...

Made some science books for kids #worldbookday

The gut microbiota: an amazing technicolour dream coat or the emperor's new clothes? Click on the article title to read more.

The gut microbiota: an amazing technicolour dream coat or the emperor's new clothes? physoc.onlinelibrary.wiley.com/doi/full/10.... - an excellent corrective to the relentless hype

Beautiful work Katarzyna, Caroline and team!

Astrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced blood–brain barrier alterations - Nature Neuroscience The mechanisms of neurovascular adaptations underlying stress resilience remain unclear. Here the authors show that the astrocytic endocannabinoid system modulates the blood–brain barrier changes duri...

So excited to share the work of the fantastic Katarzyna, 1st 🧪PhD student of my lab 🧠, out in @natureneuro.bsky.social 🥂🥳
Cheers to the team, thanks to our precious collaborators and support from @braincanada.bsky.social #CIHR @fondsrechercheqc.bsky.social #newPI

www.nature.com/articles/s41...

New RCSI research identifies key role of T cells in blood clot risk for inflammatory bowel disease patients Researchers from RCSI University of Medicine and Health Sciences have uncovered a novel mechanism linking inflammatory bowel disease (IBD) with an increased risk of a serious blood clotting disorder, ...

New RCSI research has uncovered how T cells may contribute to blood clot risk in inflammatory bowel disease.

The findings, published in @NatureComms also suggest a potential treatment approach to manage this risk.

Read more 🔗 www.rcsi.com/dublin/news-...

#RCSIdiscover @rcsi-research.bsky.social

The influence of APOE, sex, and age on cognitive performance for female and male participants.

A gene linked to age-related cognitive decline, APOE ε4, is also associated with cognitive advantage below the age of 50 in women, according to data from the @ukbiobank.bsky.social, a finding that could explain APOE ε4’s persistence in the human genome. In PNAS: www.pnas.org/doi/10.1073/...

Thanks @blacoste.bsky.social! I want to highlight that it's a new peer-reviewed, interdisciplinary open access journal: #Glia #Health #Research 🧪

All articles submitted before April 30, 2026 are 🚨 free, no publication fees! 🤑

CD45-PET is a robust, non-invasive tool for imaging inflammation - Nature A non-invasive in vivo positron emission tomography imaging approach detects inflammatory disease using various preclinical models.

Nature research paper: CD45-PET is a robust, non-invasive tool for imaging inflammation

https://go.nature.com/4jmStIF

New research offers hope for preventing epilepsy after traumatic brain injury A new international study has unveiled critical insights in understanding post-traumatic epilepsy, a condition that can develop following traumatic brain injury.

A new collaborative study led by FutureNeuro researchers at RCSI offers hope for predicting and preventing the development of epilepsy following traumatic brain injury.

The research identifies an important role for a brain receptor called P2X7.

More ➡️ www.rcsi.com/dublin/news-...

#RCSIdiscover

Check out this paper and tool that we worked on with @sloanlab.bsky.social and Ye Zhang.
Think of it as 'the Barres datasets 2.0'

Lots of input and feedback from the amazing #Glia community.

A claudin5-binding peptide enhances the permeability of the blood-brain barrier in vitro A claudin5 binding peptide enhances transport across the blood-brain barrier by transiently permeabilizing tight junctions.

The blood-brain barrier can prevent therapeutic drugs from reaching the brain.

Researchers in #ScienceAdvances have identified a peptide that increases the barrier’s permeability, showing potential for more effective drug delivery to treat brain diseases. scim.ag/4jhnWf6

Sudden urge to stick on Joy Division though...

In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds - Nature Neuroscience Mice expressing humanized mutant tau exhibit synaptic loss and behavioral abnormalities in the absence of abnormal tau conformers, suggesting that hyperphosphorylated tau can be pathological, at least...

In vivo hyperphosphorylation of #tau is associated with synaptic loss and behavioral abnormalities even in the absence of tau seeds 🧪🧠

www.nature.com/articles/s41...

A single-cell mass cytometry-based atlas of the developing mouse brain - Nature Neuroscience In recent years, valuable mRNA-based developmental atlases of the mouse brain have been made available. Here, the authors use single-cell mass cytometry to build a protein-based single-cell profiling ...

A single-cell mass cytometry-based atlas of the developing mouse brain 🧪🧠

www.nature.com/articles/s41...

Science Santa #science

Interplay between Netrin-1 and Norrin controls arteriovenous zonation of blood–retina barrier integrity | PNAS The integrity of the blood–retina barrier (BRB) is crucial for phototransduction and vision, by tightly restricting transport of molecules between ...

www.pnas.org/doi/10.1073/...

RCSI research reveals how the body clock regulates inflammation New research from RCSI has explained how the body’s internal clock influences the inflammatory process of the immune system. More ...

New RCSI research has explained how our body clock influences the inflammatory process of the immune system.

The findings could pave the way for time-targeted treatments for inflammatory diseases such as arthritis.

Read more ➡️ www.rcsi.com/dublin/news-...

#RCSIdiscover

Patrick Freyne: I am becoming a demotivational speaker – let’s all have an averagely productive December I keep meeting people who are extremely burned out. I meet them so often that I’m beginning to think burnout is something that exists by design

I'm launching a new career as a demotivational speaker (thanks to everyone who got in touch this morning - it's nice to hear it strikes a chord) www.irishtimes.com/life-style/p...

Congrats Matt!

This image shows Prof Prehn in a laboratory setting, wearing a white lab coat, pointing at a computer screen displaying scientific or cellular data in bright colors, related to medical or biological research. The logo and text in the top right corner indicate that this is associated with RCSI

New research has found that closer immune-cancer cell interactions predict better disease-free survival rates in stage III colorectal cancer.

The study was led by Professor Jochen Prehn, Investigator at the Beaumont RCSI Cancer Centre.

🔗 doi.org/10.1002/path...

#RCSIdiscover

Zebrafish glial-vascular interactions progressively expand over the course of brain development Glial-vascular interactions are critical for the formation and maintenance of brain blood vessels and the blood-brain barrier (BBB) in mammals, but their role in the zebrafish BBB remains unclear. Using three glial gene promoters—gfap, glast, and glastini (a truncated glast)—we explored glial-vascular development in zebrafish. Sparse labeling showed fewer glial-vascular interactions at early stages, with glial coverage and contact area increasing with age. Stable transgenic lines for glast and glastini revealed similar developmental increases, starting at ∼30% coverage at 3 days post-fertilization (dpf) and peaking at ∼60% by 10 dpf, and consistently higher glial coverage in the forebrain and midbrain than in the hindbrain.

And somehow I missed it going live last week 😂 - our #zebrafish glial-vascular paper is available for those finterested! One of the best ways to end 2024 as a #newPI www.cell.com/iscience/ful...

Endothelial inflammation in COVID-19 Disrupted endothelial function underlies the multiorgan complications of COVID-19

Blood vessel wall (endothelial) inflammation as a key to multi-organ complications of Covid and #LongCovid
@science.org
science.org/doi/10.1126/...

2 new studies on brain aging with sex-specific findings
—Angiogenesis factors
www.science.org/doi/10.1126/...
—Loss of gray matter
press.psprings.co.uk/jnnp/novembe...

I'd like to be added, thanks!