Granada Lab

Outside-in regulation of cellular clocks - Nature Physics Circadian clocks and cell division cycles are coupled. Now a study shows how cell-to-cell synchronization of circadian rhythms regulates cell division and growth.

@granadalab.bsky.social recently showed how circadian coupling regulates cell growth. In order to regulate the cell on the inside, we should look outside! Great pleasure to write News&Views together with Jae Kyoung Kim! @mpinb.mpg.de

www.nature.com/articles/s41...

Proud moment to see work from my PhD in the @granadalab.bsky.social featured on the cover of the April 2025 issue of @molsystbiol.org 🥹 special thanks to my talented husband who helped design this cover. Check out the full paper here: lnkd.in/eDVQuRfc.

New work out in @naturephysics.bsky.social
Led by @NicaGutu & Malthe Nordentoft + great collaborators.

We show that circadian synchrony shapes cell growth. When coordination is lost, clock–cell cycle coupling breaks down.

May help explain paradoxes in circadian cancer biology.
📖 rdcu.be/efNaY

Our latest work is out in @commsbio.bsky.social
Led by Nica Gutu & Hitoshi Ishikuma, we show how circadian rhythms shape time-of-day drug sensitivity in human cells 🕒💊. Supported by @Charité, @BMBF_Bund, @emed-sysmed.bsky.social Read: rdcu.be/ee3FQ
#chronotherapy #circadian

New research suggests the circadian clock influences breast cancer cell drug sensitivity ➡️ www.embopress.org/doi/full/10....

Circadian clock features define novel subtypes among breast cancer cells and shape drug sensitivity | Molecular Systems Biology imageimageDeep circadian phenotyping across breast cancer cell lines reveals distinct circadian subtypes and their impact on drug responses. Novel circadian-based subtypes are established among breast cancer cell models. Deep circadian ...

Happy to share a new very exciting work from my lab! Congrats to CarolinEctor and the team on their study of circadian clock dynamics in breast cancer cells, now published in @molsystbiol.org.
We identified novel circadian subtypes linked to drug sensitivity 💊
www.embopress.org/doi/full/10....

Chronobiologie in der Onkologie: Onkologische Therapien am besten zur individuell optimalen Tageszeit – Deutsches Ärzteblatt

🚀 Together with Carolin Ector, we recently published a review in the German medical journal Deutsches Ärzteblatt! 🎉

Topic: Chronobiology in Oncology ⏰💊

📌 Currently only in German

🔗 www.aerzteblatt.de/archiv/chron...

#Oncology #Chronobiology #MedicalResearch #CancerTreatment #HealthInnovation

Grateful for the excitement around our work on the best time-of-day for drug treatments! Thanks to everyone highlighting the emerging science of chronotherapy—a field built on the pioneering work of many we admire.
News summary in 7 languages: .
@SRBRHQ

nature.altmetric.com/details/166570…

Finally out! "Circadian Coupling Orchestrates Cell Growth"! Our study shows how circadian synchronization impacts the coordination of cellular division, shaping collective growth dynamics. Kudos to @NicaGutu!

biorxiv.org/cgi/content/sh…

Check out our latest pre-print! Kudos to Carolin Ector and a stellar team of collaborators for their immense effort. We've pioneered a novel high-throughput method to assess how circadian rhythms influence cellular response to drug perturbation.

biorxiv.org/content/10.110…

Fantastic work from Christian Gabriel from Kramer Lab #CharitéBerlin @NatureComms. It was a pleasure to see this very challenging project evolving. Now there is an endogenous Crispr fluorescent reporter of the circadian clock!

nature.com/articles/s4146…

Yesterday we had our first journal club! We started with this very nicely written @naturemethods from @marchafner. Highly recommended for those interested in improving their methods for the analysis of drug sensitivity.

rdcu.be/b8YIr

Wow! pyBOAT, the Biological Oscillations Analysis software passed the 8K downloads! The project is the brainchild of @tensionheadx ! Preprint:

biorxiv.org/content/10.110…

We have two open positions for PhD students interested in computational and experimental aspects of cancer research (1 experimental and 1 computational) @ChariteBerlin. Job description: Please RT

jobrxiv.org/job/charite-un…

In a meeting today I found myself referring many times to this beautiful work from Aschoff (1978), many years ahead of his time. Fig2 collects so much information about underlying oscillations from different species.

link.springer.com/article/10.100…

Beautiful explanation!
Takens' theorem in action for the Lorenz chaotic attractor via @YouTube

youtu.be/6i57udsPKms

I'm very excited to share our work on single cell responses to Chemotherapy. Our data shows that slowly proliferating tumors might in fact be vulnerable to therapy! With labs of Galit Lahav @HMS_SysBio, @molsysbio and @SimoneReber. Out in @MBoCjournal

ow.ly/zyqu50yolco

Circadian clock endogenous fluorescent tagging is now possible thanks to the great efforts from Christian Gabriel from Achim Kramer's lab. Preprint: Live-cell imaging of circadian clock protein dynamics in CRISPR-generated knock-in cells

disq.us/t/3mj6unc

Assessing the level of circadian clock dysfunction in breast cancer patients!

biorxiv.org/content/10.110…

Paving the way... 'Evaluation of Deep Learning Strategies for Nucleus Segmentation in Fluorescence Images'. Check it out. #JustAssertIt

assert.pub/papers/335216