Loïc Labache

@ohbmofficial.bsky.social, is the new OHBM abstract length really 14,000 characters? This would mean a shift from an abstract to a conference paper. If so, what are the implications for publication rights with respect to journal submissions? How are reviewers expected to review up to 40?

Flyer to join Holmes Lab

The Holmes Lab is #hiring a full-time research assistant/predoc! Our work focuses on functional brain networks-- how they change, how they are impacted in psychiatric illness, and much more!
Please rt and reach out if you’re interested 👀
Find out more holmeslab.rutgers.edu

Looking for a post-bac RA position focused on the brain bases of affective and psychotic illness?
@holmeslab-bhi.bsky.social is hiring!
@cahbir.bsky.social @rutgersbhi.bsky.social @rutgersu.bsky.social @sobp-org.bsky.social @hitop-system.bsky.social @ohbmofficial.bsky.social

One to watch! 👇🏼🔥 Be sure to tune in Monday for the live event or check out the recording on youtube, along with all our WBHI lectures. Register for the full series at wbhi.ucsb.edu/about/events We’ve got an amazing 25-26 lineup.

One mother for two species via obligate cross-species cloning in ants - Nature In a case of obligate cross-species cloning, female ants of Messor ibericus need to clone males of Messor structor to obtain sperm for producing the worker caste, resulting in males from the same moth...

Les espèces classiques de la SVT : se reproduisent 🥱

Les reines des fourmis M. ibericus :
clonent des mâles d'une autre espèce 🤯 pour se reproduire avec et créer des ouvrières hybrides 😤 tout en faisant des mâles de leur espèce pour faire des nouvelles reines 💃💃

www.nature.com/articles/s41...

New paper in Imaging Neuroscience by Elise Roger, Gaelle E. Doucet, et al:

When age tips the balance: A dual mechanism affecting hemispheric specialization for language

doi.org/10.1162/IMAG...

Excited to share that our work is now published in Imaging Neuroscience! 🧠🥳
We show how aging reshapes the brain’s language and memory networks, revealing striking shifts in hemispheric specialization across the lifespan.
Check it out @imagingneurosci.bsky.social

Thanks so much! Great to hear you enjoyed the work.

Holmes Lab is representing at #OHBM2025! 🧵 Loic
@loiclabache.bsky.social presented in the Language: Anatomy, Networks and Pathology section with his paper on "The molecular and cellular underpinnings of human brain lateralization" 🧠

The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry - Scientific Data Scientific Data - The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry

🚨 Dataset & Manuscript alert! 🚨 The Transdiagnostic Connectome Project (TCP) manuscript is now available @natureportfolio.nature.com Scientific Data! 🎉

www.nature.com/articles/s41...

🧵1👇

🚨Preprint!🚨 So excited to share my 1st major study as a postdoc at @holmeslab-bhi.bsky.social!🤘

www.biorxiv.org/content/10.1...

Using a transdiagnostic framework, we found that brain network dynamics were able to discriminate individualized psychiatric symptom profiles with high accuracy 🧵1/9👇

Thanks Donna! I take that as a compliment; hope the surprise wasn't too big.

🎨🧑‍🎨 Looking for a tool to visualize subcortical/thalamic data in 2D? Check out this python-based package I put together (subcortex-visualization on PyPI), plus a guide for creating your own custom atlas meshes and vector graphics! All feedback/tips welcome 😊

anniegbryant.github.io/subcortex_vi...

Check our latest work ‘Linking Subjective Experience of Anxiety to Brain Function using Natural Language Processing’. Our analyses link movie-evoked brain activity and subsequent interview recordings in a pediatric sample with and without anxiety disorders (doi.org/10.31234/osf...).

a man applauds with the words so proud of my team above him ALT: a man applauds with the words so proud of my team above him

Excited to share the first major piece of work and preprint from my lab! Led by Jason Kim! 🥳🎉🤘

www.biorxiv.org/content/10.1...

Newest #preprint from Holmes lab postdoc @loiclabache.bsky.social 🔥

Thanks, Clyde! I hope you enjoy reading it!

The molecular and cellular basis of human brain lateralization. Latest paper from @holmeslab-bhi.bsky.social led by @loiclabache.bsky.social. @rutgersbhi.bsky.social, @cahbir.bsky.social

Thanks so much! So glad you found the work interesting. The development of lateralization is a fascinating path to explore!

Thanks Cedric! 🙏

9/ Huge thanks to @avramholmes.bsky.social @holmeslab-bhi.bsky.social and big ups to collaborators @sidchop.bsky.social and @xi-hanzhang.bsky.social across Yale & Orygen 🦘

8/ Understanding these biological bases of lateralization has profound implications for evolutionary theory and offers clues to neuropsychiatric conditions characterized by atypical lateralization patterns.

Figure of the organization of the molecular and cellular profiles of the seven canonical intrinsic networks. We are revealing the existence of opposing lateralization profiles in language- and attention-related networks at the molecular and cellular level.

7/ Finally, our findings reveal a distinct cellular and molecular fingerprint demonstrating the brain is organized around two complementary systems: one centered around language and the other around visuospatial attention.

Figure of the cellular substrates of the neurotransmitter receptor and transporter mode underlying functional cortical lateralization.

6/ On the cellular level, intratelencephalic-projecting neurons and microglia distributions align with hemispheric specialization, linking specific cell-types to cognitive functions like language and attention.

Figure of the molecular substrates of neurotransmitter receptor and transporter modes underlying functional cortical lateralization. We show mitochondrial phenotypes as substrates for lateralization of the acetylcholine-norepinephrine axis.

5/ We further discovered mitochondrial activity asymmetry aligns with this neurotransmitter axis, suggesting energy management in cells plays a pivotal role in supporting cognitive specialization.

4/ Left-hemisphere language dominance correlates with higher norepinephrine transporter densities, whereas right hemisphere visuospatial attention is associated with increased acetylcholine receptor densities.

Canonical Correlation Analysis (CCA) results reveal the neurotransmitter receptor and transporter substrates underlying functional cortical lateralization. We are showing that an acetylcholine-norepinephrine axis underlines functional lateralization of language and visuospatial attention.

3/ Our multimodal approach integrates fMRI, PET imaging, and transcriptomic analyses, uncovering an acetylcholine-norepinephrine neurotransmitter axis central to functional lateralization.

2/ Hemispheric specialization is crucial for human cognition. The left hemisphere typically dominates language, while the right is in charge of visuospatial attention. But what's the biology behind this division?

The molecular and cellular underpinnings of human brain lateralization Hemispheric specialization is a fundamental characteristic of human brain organization, where most individuals exhibit left-hemisphere dominance for language and right-hemisphere dominance for visuosp...

🚨 New #preprint: The molecular and cellular underpinnings of human brain lateralization

🔗 doi.org/10.1101/2025...

🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇

#neuroskyence

fMRI must break out of its silo We need to develop research programs that link phenomena across levels, from genes and molecules to cells, circuits, networks and behavior.

Until recently, in-vivo brain imaging has largely been absent from… integrative efforts, limiting the opportunities to contribute our discoveries, theories or vision toward a comprehensive view of brain function, writes @avramholmes.bsky.social.

#neuroskyence

www.thetransmitter.org/future-of-fm...