Valentin Riedl

The Energetic Collapse of the Alzheimer's Brain: Metabolic Inflexibility Across Cells and Networks Metabolic inflexibility in Alzheimer's disease. Schematic illustrating the biphasic trajectory of metabolic activity relative to canonical Alzheimer's disease (AD) biomarkers. In the presymptomatic p...

Our new review is out today!

𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀

We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility.

onlinelibrary.wiley.com/doi/10.1111/...

Cover for the book "Creating Communication and Media Research Labs: A Blueprint for Success". Edited by Chad Edwards, Autumn Edwards, and Patric R. Spence. Published by Palgrave Pivot.

🧵 What does it take to build a small, scrappy, and successful communication neuroscience lab? Our lab, @gongxuanjun.bsky.social, @rachaelkee.bsky.social, Allyson Snyder, Ziyu Zhao, and I put out heads together to answer this question. Here's what we came up with: link.springer.com/chapter/10.1...

Fast hierarchical processing of orthographic and semantic parafoveal information during natural reading - Nature Communications Combining MEG, eye-tracking, and representational similarity analysis, this study shows that readers rapidly and sequentially extract orthographic and semantic information from upcoming words before fixation, supporting efficient reading.

Ever wonder how you read so fast? Your brain gets a head start—processing the next word before your eyes move. Our MEG + eye tracking study out in Nature Communications study from @thechbh.bsky.social reveals orthographic & semantic previews predicting reading speed www.nature.com/articles/s41...

Hello! It has been a while, but for the Hector Fellow Academy I created a small project at the interface of neuroscience and music. In short, it is like a neuro-jukebox of projects of friends and colleagues integrating music and art. I thought it would be nice to share here
cng-lab.github.io/kiosk

Mitochondrial origins of the pressure to sleep - Nature Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.

Nature research paper: Mitochondrial origins of the pressure to sleep

go.nature.com/40oC7Y4

Event structure sculpts neural population dynamics in the lateral entorhinal cortex Our experience of the world is a continuous stream of events that must be segmented and organized at multiple timescales. The neural mechanisms underlying this process remain unknown. In this work, we...

Your brain doesn’t just passively track time ⏳ - it structures it.
In @Science.org we show that activity in 🧠 memory circuits (LEC) drifts constantly, but makes sharp jumps at key moments, segmenting life into meaningful events. (1/2)

👉 www.science.org/doi/10.1126/...

YouTube video by Layer fMRI Faruk Gulban: Meso Veins Meet Layer fMRI in High-Speed Data Exploration for the New Mesoscopic Era

At today's layer-fMRI seminar, @ofgulban.bsky.social presented stunning high resolution vein mapping tools.
It left me quite excited.
youtu.be/0V8fSjo2T2w?...

A budget for brain metabolic water production by glucose catabolism during rest, rises in activity and sleep - Fluids and Barriers of the CNS Maintaining brain fluid homeostasis is of critical importance for creating a stable environment conducive to optimal neuronal functioning, nutrient distribution, and waste product removal. In this stu...

Your brain functions not only as a thinking organ but also as a miniature water factory. We here calculate how much water neuronal mitochondria produce by glucose oxidation: 300-400 ml. Of that amount, 100 ml go into brain's interstitial fluid. fluidsbarrierscns.biomedcentral.com/articles/10....

truely multiscale brain data on neuroenergetics

First map of human brain mitochondria is ‘groundbreaking’ achievement Hundreds of cubes of human brain tissue help scientists to chart the energy-making capabilities of various brain regions.

The brain’s energy landscape as a potential window into brain health
www.nature.com/articles/d41...

(study led by Martin Picard and Michel Thiebaut de Schotten)

Have questions about the ISMRM MiniHub in Lille, France? Get all your questions answered in an informal drop-in Zoom session with the Organizing Committee. Whether you're already registered or considering attending, stop by and ask us anything!

Register now: ow.ly/8Rgx50V6Xgr

#ISMRM #ISMRMMiniHub

Thanks to all of the NIHers and their friends who reached out to me. I am still here (DM me or Signal jeremymberg.78)

I still have a very incomplete picture but based on what I have been told, the damage to NIH and to many wonderful people who work(ed) there is/was impossible for me to imagine

1/n

Synaptome architecture shapes regional dynamics in the mouse brain | www.biorxiv.org/content/10.1...

Led by Justine Hansen

Big news: there are all sorts of different synapse types in the brain 👀‼️⤵️

Food for thought: Neuronal fuel source more flexible than previously recognized The cells primarily rely on glucose—rather than lactate from astrocytes—to generate energy, according to recent findings in mice.

Neurons primarily rely on glucose—rather than lactate from astrocytes—to generate energy,
according to recent findings in mice.

By @giorgiag-sciwriter.bsky.social

www.thetransmitter.org/metabolism/f...

📢 New preprint from the lab:

We are very excited to report the discovery of an oscillation in the Central Thalamus using rare direct recordings of human thalamic electrophysiology.

The novel oscillation is tightly coupled to specific, natural states of consciousness.🧵

David Lynch was an artist in all aspects of his life. I am a particular fan of his hair. He would have played Karl Friston in an fMRI biopic. RIP

beautiful and heartwarming, 🙏 Ida… triggering good memories about my trip to Iran

Grief Makes Us Time Travelers (Gift Article) A neuroscientist studying memory, I used to believe time was linear. Then my mother had a stroke.

Honored that a piece I wrote made it to NYTimes. It’s about how my mom’s stroke changed my connection to time, science, and nature. What a privilege to honor my mom in Modern Love.
Below is a gift link. Let me know your thoughts 🙏🏼

www.nytimes.com/2024/12/20/s...

Mapping neuropeptide signaling in the human brain | doi.org/10.1101/2024...

Neuropeptides are among the functionally diverse signaling molecules in the brain and body.

@cebric.bsky.social curates an atlas of neuropeptide receptors and relates it brain function 🧩 🧠 ⤵️

Image from the microscope showing pyramidal neurons in the neocortex

Having a difficult day, but I'm glad to have microscopy to inspire me and hopefully inspire others as well. 💔
The brain keeps being amazing. These are neurons in the neocortex #FluorescenceFriday 🔬

Quick reminder that Elsevier's share price has doubled in the past 5 years:

www.relx.com/investors/sh...

beautiful and elegant 👏

Here are some important populations of columnar neurons in the #Drosophila right optic lobe, from the #connectome released in April 2024 again. Note the subtle variations in morphologies. I made this video with Michael Reiser ( @michaelreiser.bsky.social), using neuVid driving #Blender.

renzo, what did u take 🤣? …yet, beautiful!

Intracranial lymphatic vessels in zebrafish with Qdot angiography in magenta, lymphatics in green, Bone in blue. Learn more at Castranova et al. 2020 Circulation Research

Intracranial lymphatic vessels in a larval zebrafish. Credit to @zebrafish007.bsky.social. #ZebrafishZunday 🧪

OK If we are moving to Bluesky I am rescuing my favourite ever twitter thread (Jan 2019).

The renamed:

Bluesky-sized history of neuroscience (biased by my interests)

Our new study shows that SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it🔬🧠🦠🧵Your weekend read👇
@cellpress.bsky.social
cell.com/cell-host-mi...

please add me, 🙏

please add, 🙏

After a couple weeks, I've added a few hundred of you to Brain and Mind by request. The list is really an awesome source of posts in neuroscience, cognitive neuroscience, and compneuro. Has basically replaced my home feed! bsky.app/profile/did:...