Wilhelm Lab

Excellence Strategy Funds Bonn Cluster for Immune Research The Bonn Cluster of Excellence ImmunoSensation will be funded for a further seven years as part of the Excellence Strategy of the German federal and state…

Hurray! ImmunoSensation will go on! 🥳
The @dfg.de just announced that ImmunoSensation3, focussing on Immune Diversity will be funded!
Let us #celebrate 7 more years of #immunology in #Bonn 🎉

www.immunosensation.de/news/immunos...

Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation - Nature Immunology Tuft cells constitutively express IL-25 to sustain ILC2 homeostasis in the intestine, but mechanisms driving IL-25 secretion have been unclear. Here, Feng et al. find that tuft cells express IL-17RB, ...

Congratulations Christoph an collegues!! 🎉🥳🥳🎊https://www.nature.com/articles/s41590-025-02104-y

Alaaf!!!

Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST Sprenger et al. used a systematic approach to identify how mitochondria remodel their metabolome in response to exercise. The diet-derived, atypical amino acid ergothioneine (EGT) accumulates in muscl...

www.cell.com/cell-metabol...

Die goldene Zeit des Donald Trump Der neue US-Präsident zerstört Institutionen, Wissenschaft, die eigene Zukunft.

whoever speaks german, please read this article by constantin seibt from the @republik.ch (unfortunately there is no english translation yet)

www.republik.ch/2025/02/07/d...

Revised and Extended: What's Happening Inside the NIH and NSF

Very important information to understand what is currently going on in the US. Please share and distribute www.science.org/content/blog...

Kicking off the 2nd funding period of our SFB1454 on #metaflammation ! Lots of great discussions and visiting our #healthybition at the #museumkoenig in Bonn! Go and visit the exhibition until end of October 2025!

🚨 Open #position! The group of Christoph Wilhelm at the University Hospital Bonn is looking for a

Postdoctoral fellow (m/f/d) – metabolic and nutritional regulation of immunity

Application deadline is February 10!

Visit our website for more information.

#job #postdoc #science #immunology

We are hiring! 📣Interested in how host metabolism, diets, #fasting and #ketogenesis affect the immune response? 👇We are offering a #postdoc position to work on the interplay of host metabolism and immunity. Apply by email or DM directly.

Hypoxia-inducible factor 2α promotes protective Th2 cell responses during intestinal helminth infection https://www.biorxiv.org/content/10.1101/2025.01.09.631414v1

Cheers

Would be great to be added. Cheers

What defines the #WesternLifestyle and how does it impact our health and the planet? 🌍
“What the Health – Eine Welt. Deine Gesundheit!” explores these connections!
Visit our #healthybition and the accompanying program
📍 @museumkoenig until 26.10.2025
#unibonn #metaflammation #unistiftung

Thermally induced neuronal plasticity in the hypothalamus mediates heat tolerance - Nature Neuroscience Ambroziak, Nencini, Pohle and colleagues identify a slowly emerging plasticity mechanism in a discrete set of hypothalamic preoptic neurons that is triggered by long-term heat exposure and that drives...

My inaugural post on Bluesky - quite fittingly, I'm thrilled to share our first study on heat acclimation, which identifies a neuronal mechanism that drives heat tolerance in mice. (www.nature.com/articles/s41... )
Here is the gist 🧵 (1/n):

Really glad we pulled this of together! @wachtenlab.bsky.social, Andreas Schlitzer and all PIs from #Metaflammation

Also, we will be hiring a postdoc and PhD. Watch this to place for more info or DM/email me in case you are interested.

DFG fördert sieben neue Sonderforschungsbereiche

Thanks so much DFG for funding our CRC #1454 #Metaflammtion for another 4 years. Looking forward to unravel the immune mechanisms underlying #obesity and #diabetes together with an excellent team of scientists.
www.dfg.de/de/service/p...

www.sfb1454-metaflammation.de/sfb-1454/news

Liver X receptor unlinks intestinal regeneration and tumorigenesis - Nature Liver X receptor drives epithelial Areg-mediated intestinal regeneration, while preventing tumour growth through adaptive immune responses.

Congratulations @ejvillablanca.bsky.social and colleagues, super nice paper! www.nature.com/articles/s41...

many new members, many still to join #neuroscience #immunology

Please add

Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19 - Nature The ketone body β-hydroxybutyrate can be used as an alternative carbon source by T cells to maintain their function during severe respiratory viral infections, including infection with&...

Ever wondered how fasting is benefiting the adaptive immune response? In @Nature we show that #ketogenesis promotes the function of #tcell in severe respiratory viral infections by providing #ketonebodies BHB as carbon source. Final edited version: www.nature.com/articles/s41...