Christoffer G. Alexandersen

Network Models of Neurodegeneration: Bridging Neuronal Dynamics and Disease Progression Neurodegenerative diseases are characterized by the accumulation of misfolded proteins and widespread disruptions in brain function. Computational modeling has advanced our understanding of these proc...

🧠 New preprint 🧠
We review comp. models of brain activity and protein spread in neurodegeneration, and argue that linking them is key to understanding and intervention
With @danisbassett.bsky.social Y. Iturria-Medina
@mxhend.bsky.social K. Brynildsen @gsbrennan.bsky.social
arxiv.org/abs/2509.05151

⭐New preprint: "A multiscale theory for network advection-reaction-diffusion"

with @alaingoriely.bsky.social and Emilia Cozzolino

arxiv.org/abs/2509.06546

Modelling cerebrovascular pathology and the spread of amyloid beta in Alzheimer’s disease: royalsocietypublishing.org/doi/10.1098/... #ProcA #Alzheimers #biophysics

In this paper, we connect local damage to brain vasculature to global progression of toxic proteins leading to neurodegenerative diseases.
royalsocietypublishing.org/doi/epdf/10....
We identify situations where disease initiation can be caused by focal hypoperfusion following vascular injury.