AACR Journals

Izalontamab (SI-B001), a Novel EGFRxHER3 Bispecific Antibody in Patients with Locally Advanced or Metastatic Epithelial Tumor: Results from First-in-Human Phase I/Ib Study AbstractPurpose:. Izalontamab (SI-B001) is a novel EGFR×HER3 bispecific antibody. This first-in-human phase I study presents the safety and pharmacokinetics of izalontamab.Patients and Methods:.…

In the November 1 issue of Clinical Cancer Research, read the Phase 1 Study: Izalontamab in advanced epithelial tumor.

Check out the brand new commentary in Blood Cancer Discovery buff.ly/s1XKgeR

Beyond Expansion: Tumor Debulking as Key to Improving CAR T-Cell Potential in Lymphoma

Not only do AACR Members receive a 10% discount on publishing fees, but some AACR scientific working groups offer additional discounts on top of this. Learn more: buff.ly/12PgSmX

Early Career Award | Clinical Cancer Research | American Association for Cancer Research Early Career Award | Clinical Cancer Research | American Association for Cancer Research .aacrcontent .banner{ width: 100% margin: -20px; } .aacrcontent .banner-sm{ display: none; } .right{float:…

The Clinical Cancer Research Early Career Award recognizes outstanding early career investigators who have authored original articles published in the journal that have made a significant impact in one or more of the fields represented by the journal.

Nominations are open!

When you submit to an AACR Journal, you'll benefit from rapid decision and publication times. Learn more about the Manuscript Turnaround Guarantee for Active AACR Members: buff.ly/KP7I5Z6

Molecular Cancer Therapeutics is the central hub for #FirstDisclosures of novel cancer therapeutics. Catch up on the latest articles: buff.ly/4JBMh5y

"Editors and staff are fantastic to interact with. It is always easy to reach out, get feedback and suggestions." -Sandra Misale, Cancer Discovery Author

See more of what our authors are saying about publishing with the Journals. buff.ly/7x8ra8e

Cancer Research Early Career Award | Cancer Research | American Association for Cancer Research Cancer Research Early Career Award | Cancer Research | American Association for Cancer Research .aacrcontent .banner{ width: 100% margin: -20px; } .aacrcontent .banner-sm{ display: none; }…

The Cancer Research Early Career Award recognizes outstanding early career investigators who have authored peer-reviewed, original articles published in the journal that have made a significant impact in one or more of the fields represented by the journal.

Nominations are open!

Read this recent In Focus article in Blood Cancer Discovery, The Global State of Blood Cancers: An Ongoing Challenge by @lilliansiu.bsky.social buff.ly/lzyYvgE

Read this collection of impactful Blood Cancer Discovery articles that highlight advanced lymphoma research by leveraging novel tools and techniques, uncovering molecular networks that drive oncogenesis and progression, and bringing innovative therapies to patients. buff.ly/q3NmZc2

Immune MRD Status Informs Tumor MRD Outcome Prognostication in Patients with Multiple Myeloma on Lenalidomide Maintenance AbstractPurpose:. Lenalidomide (Len) maintenance is the most frequently utilized approach for newly diagnosed patients with multiple myeloma following induction therapy with/without consolidative…

In the November 1 issue of Clinical Cancer Research, Immune MRD in MM patients on lenalidomide maintenance.

Read article collections featuring impactful, cutting-edge research on Tumor Metabolism, Cancer Health Disparities, and more: buff.ly/Oi8by86

The Cancer Discovery Early Career Award recognizes outstanding early career investigators who have authored peer-reviewed, original articles published in the journal that have made a significant impact in one or more of the fields represented by the journal.

Nominations are open! buff.ly/jUwZsdd

New article type from Cancer Epidemiology, Biomarkers & Prevention: The Resource Report covers major population-focused data resources, including cohorts, consortia, networks, registries, and other valuable datasets.

➡️Read the collection: buff.ly/MFoGugc
➡️Submit a Resource Report: buff.ly/FEFJy8y

Read the article: Systematic Engineering of TROP2-Targeted CAR T-Cell Therapy Overcomes Resistance Pathways in Solid Tumors buff.ly/czDawOy

Systematic Engineering of TROP2-Targeted CAR T-Cell Therapy Overcomes Resistance Pathways in Solid Tumors The authors show that biparatopic CARs targeting dual epitopes of TROP2 overcome the resistance seen to current TROP2-targeted ADCs, highlighting the potential of rational structure-based CAR…

This Cancer Immunology Research article shows that biparatopic CARs targeting dual epitopes of TROP2 overcome the resistance seen to current TROP2-targeted ADCs, highlighting the potential of rational structure-based CAR engineering to overcome resistance to antibody-based therapies in solid tumors.

Did you know - AACR Journals offers simultaneous publication opportunities. Contact Karen Honey, Executive Editor of Cancer Immunology Research, about submitting your related manuscript: karen.honey@aacr.org

Learn how AACR’s #openaccess, peer-reviewed journal—Cancer Research Communications—supports authors from presubmission through publication: buff.ly/NTCCGgR

📣 New collection alert!

Advances in Targeted Protein Degradation: PROTACs and Molecular Glues buff.ly/xdWDulw

This collection features recent research and review articles highlighting key advances in PROTAC and molecular glue development.

DLBCL Cells Emerge after CD19 CAR T Cells with Cross-Antigen Resistance and a Gene Signature Predictive of Clinical CAR T-cell Response Acquisition of DLBCL-intrinsic CD19 CAR-T cell therapy resistance in cell lines identifies a cross-antigen resistant phenotype with a gene signature predictive of clinical CAR-T response.

New in Blood Cancer Discovery: Cancer Cell–Intrinsic CAR T Resistance in #DLBCL

Acquisition of DLBCL-intrinsic CD19 CAR-T cell therapy resistance in cell lines identifies a cross-antigen resistant phenotype with a gene signature predictive of clinical CAR-T response. Read more:

Inadequate CAR T-cell infiltration into solid tumors limits efficacy. The authors show that engineering CAR T cells to express osteopontin can overcome physical barriers in solid tumors, offering a promising strategy to improve CAR T-cell infiltration and efficacy.
Read more: buff.ly/BeV3GQ4

Tunneling CARs: Increasing CAR T-Cell Tumor Infiltration through the Overexpression of MMP-7 and Osteopontin-b Inadequate CAR T-cell infiltration into solid tumors limits efficacy. The authors show that engineering CAR T cells to express osteopontin can overcome physical barriers in solid tumors, offering a…

From the November issue of Cancer Immunology Research, check out Tunneling CARs: Increasing CAR T-Cell Tumor Infiltration through the Overexpression of MMP-7 and Osteopontin-b

Robert Kruger, PhD, Senior Executive Editor of Cancer Discovery, joined Zhongshan Hospital Assistant President Qiang Gao, PhD, to chair the opening session of the 2025 CACA Cancer Discovery Symposium at CCHIO 2025. We thank all of the speakers for their contributions to an outstanding program.

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#ICYMI: Nominations for the 2026 Early Career Awards are open. The Award recipients will be invited to the Journals Reception that takes place during the AACR Annual Meeting and awarded $1,500. Find out more: buff.ly/Vhxuyt5

"The journal selection process was straightforward, aligning well with our research focus." -Minah Kim, Cancer Research Author

See more of what our authors are saying about publishing with the Journals. buff.ly/7x8ra8e

The Immuno-oncology collection highlights recent advances in immuno-oncology, including identification of biomarkers of response to immunotherapies, neoantigen vaccine development, antibody therapies, and cellular therapies. Check it out: buff.ly/L4GpWAx

Read the related article in Clinical Cancer Research, "SJPedPanel: A Pan-Cancer Gene Panel for Childhood Malignancies to Enhance Cancer Monitoring and Early Detection." doi.org/10.1158/1078...

Nominations for the 2026 Early Career Awards are open for Cancer Discovery, Cancer Research, and Clinical Cancer Research!

View criteria and be the first to submit a nomination: buff.ly/Vhxuyt5

Read the new article just published in Blood Cancer Discovery: Tandem duplications in UBTF create XPO1-dependent nuclear export signals that reveal a leukemic therapeutic dependency
doi.org/10.1158/2643...