Vijay Ramani

🚨 Requesting help:

I am looking for an agent who can facilitate more speaking gigs, podcast appearances, and interviews with journalists

I want to more widely share my story and expertise as a trans geneticist who understands the reality and complexity of "biological sex" 🏳️‍⚧️🧬

Please signal boost?

No justice, no science. Fuck ICE.

If you are a scientist funded by NIH and agree that if the HHS/NIH bill is held hostage by linkage for funding to DHS/ICE, we need to shutdown both and save lives, its time to speak up. Right now, with a few exceptions, the silence is deafening

Common variation in meiosis genes shapes human recombination and aneuploidy - Nature Analysis of data from pre-implantation genetic testing sheds light on the genetic basis of meiotic-origin aneuploidy, the leading cause of human pregnancy loss, identifying common genetic variants ass...

Pregnancy loss is common in humans, and chromosomal abnormalities are the leading cause. Using genetic data from ~140,000 IVF embryos, we show that maternal variation in meiosis genes influences recombination and aneuploidy risk.

First authors: @saracarioscia.bsky.social & @aabiddanda.github.io

positive / negative feedback always a possibility though. To extend your analogy --> sound engineers in audience move around the crowd and update speaker output across the space depending on crowd (louder in some cases!). Point still stands but the details genome-wide are probably important too.

A picture of current members of the Groth lab

Congratulations to @groth-anja.bsky.social on receiving the Novo Nordisk Foundation Jacobæus Prize 🏆 we’re proud to see Anja's mentorship, leadership, & pioneering work in epigenetic cell memory getting top recognition 👏 celebrating the contributions of past & present lab members to this work too 🥳

Oof.

Read in Nature: nature.com/articles/s41586-025-09899-8

Stress controls epigenetic inheritance!

A histone ubiquitylation-based regulatory hub links stress/environmental signaling to heterochromatin self-propagation and epigenetic inheritance-reshaping how we think about development, drug resistance, and cancer
👉 nature.com/articles/s41586-025-09899-8

Ninhydrin as a covalent warhead for chemical proteomic-enabled discovery and selective engagement of reactive arginines Covalent molecules have emerged as next-generation therapeutics and as powerful tools for perturbing fundamental biological processes. Chemical proteomic methods to screen for reactive proteinaceous a...

Is arginine the new cysteine?! Check out our lab's latest in collaboration with @ianseiple.bsky.social's team where we introduce ninhydrin as a selective covalent warhead and probe targeting reactive arginines.
www.biorxiv.org/content/10.6...

Oo send on over the list @reitergroup.bsky.social plz!!!

Intrigued by a long-standing conundrum in small RNA biology—how nuclear Argonaute proteins silence transposons when they *need* target transcription for their own recruitment—we studied the piRNA pathway.

And found a hidden RNA-decay axis from Piwi to the RNA exosome.

Ladies and gentlemen... the weekend. (also: you are important and are not alone 🧡)

Daniele's lab's work demonstrates clearly the link between loop extrusion and regulated gene expression; context & cell-type matter. Statements like "more about X, less about Y" are only useful if context is specified. Homology search isn't relevant in a post-mitotic cell type.

Known for decades: DNA sequence drives nucleosome "rotational positioning" (which face of DNA contacts histones)

But: How does this persist when remodelers & transcription constantly mobilize nucleosomes? Our new preprint 1/ :

www.biorxiv.org/content/10.6...

Escape from X inactivation is directly modulated by Xist noncoding RNA Nature Cell Biology - The authors show that increased Xist RNA levels can induce de novo silencing of genes that normally escape X inactivation. SPEN depletion prevents the silencing of escape...

Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.

Menin-MLL1 complex cooperates with NF-Y to promote hepatocellular carcinoma survival Chromatin regulators are frequently mutated or aberrantly expressed in hepatocellular carcinoma (HCC), suggesting that the dysregulation of chromatin …

www.sciencedirect.com/science/arti...

Cohesin guides homology search during DNA repair using loops and sister chromatid linkages Accurate repair of DNA double-strand breaks (DSBs) is essential for genome stability, and defective repair underlies diseases such as cancer. Homologous recombination uses an intact homologous sequenc...

@science.org🧬Cohesin guides homology search during DNA repair using loops and sister chromatid linkages | Science www.science.org/doi/10.1126/... @fedeteloni.bsky.social @danielgerlich.bsky.social et al.

Oh hey, looks like I can upload longer videos here now!
Here’s my most recent one covering the latest findings on ecDNA retention mechanisms from the Chang & Mischel labs.

Oxidative phosphorylation complexes contain subunits encoded by both the nuclear and mitochondrial genomes. How do cells coordinate the synthesis and assembly of these complexes at the inner membrane? We teamed up with Martin Ott (@mitolab.bsky.social) to address this in two recent papers.

Overview of Integrated Robotic Imaging and Sequencing, IRIS

We just released IRIS (7+yrs project), a tech we believe will transform cell biology by pairing high-resolution cell images with matched #scRNAseq, letting us interpret cellular form by its molecular ground truth.
Huge tx to @JohannesBues, @JoernPezoldt, @CamilleLambert et al.
shorturl.at/zgY8Z

Here is a copy of last year's Twitter thread explaining our preprint - jump to (21) for the new stuff 👀

Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function

now revised and journal accepted at www.science.org/doi/10.1126/...

🧵👇

Man it would be so cool if, in the year 2025 of our lord, we could all just be chill and celebratory about nice professional things being announced for our colleagues in molecular biology.

Unrelated, anyone reading absolute Batman? Bc it slaps.

POSTDOCTORAL FELLOW - Toronto (City), Ontario (CA) job with Taipale Lab, Donnelly Centre, University of Toronto | 12849004 The Taipale lab in the Donnelly CCBR and University of Toronto is looking for a highly motivated Postdoctoral Fellow

We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...

RNA polymerase II coordinates histone deacetylation at active promoters Transcription initiation limits histone acetylation and H2AZ incorporation at promoters.

Unpause! I'm super happy to now be able to share the published version of our paper at Science Advances showing that:
1) active histone mods occur independently of transcription
2) transcription coordinates histone deacetylation at active promoters
www.science.org/doi/10.1126/...

😧😂

Reads straight off the PacBio. HiFiASM. Good man. 😂😂😂

Psychedelics and immortality: Nature went to a health summit starring RFK and JD Vance The Make America Healthy Again summit, attended by health secretary Robert F. Kennedy Jr and vice-president JD Vance, gave a sense of what’s driving US health policy.

Read my full story here!

Psychedelics and immortality: Nature went to a health summit starring RFK and JD Vance

www.nature.com/articles/d41...

Today in @nature.com, in work led by @adititm.bsky.social, we report the ability to prompt Evo to generate functional de novo genes.

You shall know a gene by the company it keeps!

Very excited to present OpenCGChromatin🔥🔥🔥

A new coarse-grained model that probes full chromatin condensates at near-atomistic resolution to reveal the molecular regulation of chromatin structure and phase separation

Brilliantly led by @kieran-russell.bsky.social, with the Rosen and Orozco groups

Major new direction in the lab: hacking human cell biology with pathogen effectors (eORFs) - amazing collaboration with @miketilapia.bsky.social lab. Huge congrats to first authors Tomas & He & all co-authors! Check out the pre-print on @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...