Ryan Flynn

Another NIH institute loses its director Health department declines to renew Lindsey Criswell, head of arthritis institute, to another 5-year term

www.science.org/content/arti...

Magnetic mixer improves 3D bioprinting A new approach developed at MIT aims to solve a core limitation in 3D bioprinting, by actively preventing cell sedimentation within bioinks, allowing for more reliable and biologically consistent 3D p...

Great MIT News feature on how our lab is tackling one of the most significant challenges in 3D #bioprinting: gravity-driven cell sedimentation! Our modular platform prevents clogged nozzles + uneven cell distribution, enabling fabrication of large-scale viable tissues:

news.mit.edu/2026/magneti...

China turns the tables in biotech For at least a century, major scientific research initiatives have reliably occurred in the United States, usually in response to geopolitical competition. This helped establish the country’s status a...

“Success in US science has come from sustained funding and welcoming the best talent from around the world, yet both of these advantages are in decline”

www.science.org/doi/10.1126/...

Profiling Glycoproteins Enriched by Multinanoparticle Protein Corona Biofluids, such as plasma and cerebrospinal fluid (CSF), present significant challenges for proteome and glycoproteome analysis due to their complex protein composition and wide dynamic range of prote...

A month behind the times, but I wanted to share an update from @emmajays.bsky.social and other co-authors in @riley-research.bsky.social. Our manuscript "Profiling Glycoproteins Enriched by Multinanoparticle Protein Corona" is now published in Analytical Chemistry:

pubs.acs.org/doi/abs/10.1...

Dear friends and colleagues,

I am excited to share a preprint describing my take on extracellular targeted protein degradation (eTPD) - a proximity modality termed Sheddase-Targeting Chimeras (SHEDTACs).

www.biorxiv.org/content/10.6... 👀

Bluesky Map Interactive map of 3.4 million Bluesky users, visualised by their follower pattern.

I made a map of 3.4 million Bluesky users - see if you can find yourself!

bluesky-map.theo.io

I've seen some similar projects, but IMO this seems to better capture some of the fine-grained detail

🧪🧬New preprint We present cryo-EM structures of reconstituted CTCF–nucleosome complexes, showing CTCF dimerization drives nucleosome oligomerization into defined higher-order assemblies. Disrupting CTCF–CTCF interfaces in mESCs reduces looping and impairs differentiation. tinyurl.com/CTCF-nucleos...

Hope it’s was interesting!

Latest preprint from the lab - what does S1P do to neutrophils ? Click the link to find out… www.biorxiv.org/content/10.6...

On the balance of knowledge - Nature Reviews Immunology Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern complex systems.

Too much data, too little thinking.
A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read.
@Yale
www.nature.com/articles/s41...

Excited to share our latest preprint on work led by postdoc Robert Lusi (@rflusi.bsky.social)! Introducing ALTER (AGO-Led Targeted Editing of RNA) for non-downregulatory RNA manipulation by repurposing hAGO2, non-immunogenic and capitalizing on evolution. www.biorxiv.org/content/10.6...

Exciting news! The lab is moving to Colorado at @cuanschutz.bsky.social 🎉
We’ll be recruiting at all levels—stay tuned!

Both chambers of Congress have now passed the FY26 minibus with NIH provisions. The President will sign.

(1) $48.7 billion for NIH
(2) Full IDC recovery
(3) No more multi-year funding
(4) No NIH reorganization, maintaining the current IC structure.

🧬📄 Preprint update (v2): We added new biochemical experiments that clarify how IWS1 associates with the transcription elongation complex and further define competition between IWS1 and RECQL5. 🧪⚙️
www.biorxiv.org/content/10.1...

Structural model is already available in the PDB (9MLC).

New #3Dbioprinting paper out today in Device @cellpress.bsky.social! Presenting MagMix: a compact modular platform for active in situ bioink mixing during bioprinting. MagMix uses a magnetic propellor to prevent cell settling, enabling consistent fabrication of large tissues: doi.org/10.1016/j.de...

GlycoRNA complexed with heparan sulfate regulates VEGF-A signalling - Nature Heparan sulfate proteoglycans facilitate the assembly of clusters of glycoRNAs and cell surface RNA-binding proteins, which negatively modulate VEGF-A signalling and angiogenesis.

Grab ur weekend coffee and treat yourself with the latest Flynn wisdom

www.nature.com/articles/s41...

@raflynn5.bsky.social Consistently advancing the RNA biology through beautiful and inspirational discoveries.

👏🏾👏🏾👏🏾👏🏾👏🏾

My quote of the day

We have also arranged things so that almost no one understands science and technology. This is a prescription for disaster. We might get away with it for a while, but sooner or later this combustible mixture of ignorance and power is going to blow up in our faces.

Carl Sagan

Hallmarks of cancer—Then and now, and beyond Hanahan revisits the evolving framework of cancer hallmarks, synthesizing 25 years of conceptual refinement into a multidimensional view of tumor biology. This review highlights how aberrant capabilit...

Today at Cell: A new #HallmarksofCancer review by Doug Hanahan: www.cell.com/cell/fulltex...
This review marks 25 years since the original seminal Cell review by Hanahan & Robert Weinberg and its impactful follow up in 2011.
@cp-cell.bsky.social @cellpress.bsky.social

Hallmarks of cancer—Then and now, and beyond Hanahan revisits the evolving framework of cancer hallmarks, synthesizing 25 years of conceptual refinement into a multidimensional view of tumor biology. This review highlights how aberrant capabilit...

Follow up to Doug Hanahan’s visionary article about the stages of cancer development from back in the 1990s

www.cell.com/cell/fulltex...

Using electronics to build biohybrid robots with physical intelligence - Nature Electronics Biohybrid robots, which rely on living muscles to drive force generation, could be of use in applications ranging from microsurgery to unmanned exploration. But the development of untethered and auton...

Out today in Nature Electronics: we share our perspective on how instrumenting biohybrid robots with onboard #bioelectronics capable of integrated sensing, control, and power can enable real-world deployment of muscle-powered machines.

www.nature.com/articles/s41...

#Robotics #TissueEngineering

Congrats Nikolai!

Thanks a lot Ivan!

Ty Rohan!

Clusters of glycoRNAs & cell surface ribonucleoproteins negatively modulate heparan sulfate-mediated signalling in the context of angiogenesis driven by VEGF-A @nature.com @bostonchildrens.bsky.social @raflynn5.bsky.social
www.nature.com/articles/s41...

Huge advance in glycoRNA biology. Congrats to @raflynn5.bsky.social and all of the wonderful authors! Can’t wait to see what you guys do next!

Thanks Karim!

Thanks Tim, wonderful collaborating with you too!

Ty Marcin!

GlycoRNA complexed with heparan sulfate regulates VEGF-A signalling - Nature Heparan sulfate proteoglycans facilitate the assembly of clusters of glycoRNAs and cell surface RNA-binding proteins, which negatively modulate VEGF-A signalling and angiogenesis.

A new function for GlycoRNAs!! The GlycoRNA-Heparan sulfate complex on the cell surface controls VEGF-A signaling and angiogenesis. Superexciting findings from Ryan Flynn's lab. Congratulations to all authors!! @raflynn5.bsky.social www.nature.com/articles/s41...

Thanks Vijay