A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor pubmed.ncbi.nlm.nih.gov/40954149/ #cryoEM
16.09.2025 11:29 — 👍 2 🔁 2 💬 0 📌 0
Thank you, Steve!
16.09.2025 03:51 — 👍 0 🔁 0 💬 0 📌 0
Another manuscript from our group this week with the first structures of the human P2X7 receptor facilitating development of a novel scaffold for P2X7R antagonists:
urldefense.com/v3/__https:/...
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15.09.2025 18:11 — 👍 9 🔁 4 💬 1 📌 0
Subtype-specific structural features of the hearing loss-associated human P2X2 receptor pubmed.ncbi.nlm.nih.gov/40938707/ #cryoEM
13.09.2025 18:40 — 👍 2 🔁 1 💬 0 📌 1
Our latest work on the human P2X2 receptor. We identified an alternate desensitized state conformation that provides insight into how ATP enters and/or leaves the pocket.
www.pnas.org/doi/10.1073/...
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14.09.2025 03:54 — 👍 7 🔁 1 💬 0 📌 1
A true Physician-Scientist and @OHSUSOM #MDPhD alum, Dr. Steve Mansoor, sharing details about how his lab uses #DrugDesign principles to fit the ligand into the target receptor like a jigsaw piece. 🧩Thank you for your presentation Dr. Mansoor! @OHSUNews @OHSUCardio @OHSUSOM
25.04.2025 19:10 — 👍 5 🔁 3 💬 1 📌 1
The KCVI research retreat was a great success this year.
Very happy to participate. Looking forward to making this an annual event!
26.04.2025 00:55 — 👍 5 🔁 3 💬 1 📌 0
YouTube video by CryoEM Service Centers
March 27, 2025: Adam Oken, Oregon Health and Sciences University
Adam Oken from our lab gave a great presentation summarizing some of the work we have been doing.
If you are interested, please watch a recording of his seminar, linked here:
youtu.be/IdcoLJc7X8M
30.03.2025 18:15 — 👍 2 🔁 1 💬 0 📌 0
A paper from our group published a couple of months ago.
02.03.2025 09:16 — 👍 2 🔁 1 💬 0 📌 0
I am fortunate to have such a fantastic collaboration with amazing scientists from around the world.
26.02.2025 03:52 — 👍 2 🔁 1 💬 0 📌 0
Ion channels, biophysics, chemical biology, protein engineering and molecular neuroscience; Professor at University of Copenhagen; www.theplesslab.com
Cardiac Surgeon & Informatician, Oregon Health & Science University | Faculty, OHSU Surgical Data & Decision Sciences Lab
Steve Reichow (PI), Laboratory of Biomolecular #CryoEM at Oregon Health & Science University (OHSU) and Pacific Northwest Cryo-EM Center (PNCC) ❄🔬 https://www.reichowlab.com/
Assistant Professor at Oregon Health & Science University (OHSU) | Structural Biology | Membrane proteins | Organelle structure and function | Fatty-acid metabolism | Former postdoc- Stroud lab, UCSF | https://www.mguptalab.com | #NewPI
The Vollum comprises a vibrant and diverse scientific community focused on understanding fundamental biological mechanisms: https://www.ohsu.edu/vollum-institute
The OHSU Brain Institute is among the top institutions in the nation for NIH-funded neuroscience research.
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Official account. OHSU | Oregon Health & Science University is where healing, teaching and discovery come together.
Assistant Professor @ OHSU • Structural Biologist • Programmer • Coffee Roaster • he/his/him • Cryo-electron tomography, membranes, infectious bacteria, mitochondria. #teamtomo #cryoET http://tomo.science
Assistant Professor at the University of Iowa studying ion channels and other membrane proteins in 🦠 | Previously at HHMI Janelia and MSK Cancer Center | Avid 🥾 and 🎻.
Electron microscopist, orchid lover, BBQ fanatic
Pathogen entry into cells, host immune responses & vaccine design: structural biology, protein design, virology & immunology @hhmi.bsky.social
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Postdoc at OHSU studying synapses and receptors using cryo-electron microscopy // cryo-EM & cryo-ET // also <3 ⚽ 🎻 ⛰️ ⛷️ 🐶
Structural neurobiology lab @Cold Spring Harbor Laboratory. Cryo-EM, X-ray crystallography, Electrophysiology, Membrane protein biochemistry, Molecular neuroscience, Neuroimmunology. https://furukawalab.labsites.cshl.edu/
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