PlessLab

Phosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8)

Preprint: www.biorxiv.org/content/10.1...

When I started working on ion channels 20+ yrs ago, I could have never imagined how many channels there are to explore! Now I’m delighted to be heading to thematic meetings on two of our favorite channels in the span of just weeks - can’t wait to catch up with the ASIC and NALCN communities!

Thanks so much for contributing to this!!

A huge thank you to everyone involved and of course @lundbeckfonden.bsky.social, @carlsbergfondet.dk and DFF for funding.

Collaborator @amelierocks.bsky.social complemented this with predictions of protein stability and conservation scores. In combination with functional work this establishes a framework for classifying suspected disease variants, which we hope will aid assessment of NALCN variant pathogenicity

@chowhanchua.bsky.social implemented use of a combination of multiple parameters derived from two-electrode voltage-clamp electrophysiology recordings. These allow us to classify LoF and GoF phenotypes and to provide mechanistic insight into the molecular mechanism underlying specific variants.

De novo and inherited NALCN variants can lead to severe developmental syndromes. Although variants of uncertain significance or presumed pathogenic variants have been studied in heterologous systems before, there is no generally accepted framework on how to assess or predict variant pathogenicity.

After years in making, I am glad to be able to share our attempt on establishing a framework for combined functional and computational assessment of variant pathogenicity in the sodium leak channel NALCN:
www.biorxiv.org/content/10.1...

Momentum is building! Join us for the 51st Lorne Proteins Conference Feb 8–12, 2026, Mantra Lorne on the Great Ocean Road, for fun networking activities 🏐 🎾 🥗 🪩 and breathtaking surf-coast accessibility 🏖️ 🏊 🏄 in the generous breaks between sessions!

🔗 Register here: www.lorneproteins.org/register

Come to the second edition of the world wide sodium channel conference! Submit an abstract by September 26.

Adriano Senatore @utoronto.ca and colleagues explore the evolutionary origins of the sodium leak channel NALCN and its ancillary subunits FAM155/Mid1, UNC79, and UNC80. rupress.org/jgp/article/...

#Evolution #IonChannels

2nd #WSCC26 will take place in Grindelwald (Switzerland) 🚠 from 4th to 6th of February, 2026.

🌍 Join @lampertlab.bsky.social , @antoniospantazis.bsky.social, @khannalabuf.bsky.social, and others.

💡 Submit abstracts by the 26th of September, 2025:
lnkd.in/eDhPUVKd

💻 More info:
lnkd.in/eJw9pfMz

Great to see so much exciting ion channel/membrane protein work going on in the far North!

Wonderful visit to beautiful Bergen, Norway. Big thanks to @herculeria.bsky.social for hosting and to Tim Lynagh for guiding me up the local hills

🥁🥁🥁
The 51st Lorne Conference on Protein Structure and Function is officially live! After the resounding success of the 50th Lorne Conference in 2025 celebrating five decades of pioneering science and community, the legacy continues... 🏄🏖️🌞

February 8–12, 2026

Register here: www.lorneproteins.org

Congratulations to you and the team - amazing work!

Prevalence of errors in lab-made plasmids across the globe Abstract. Plasmids are indispensable in life sciences research and therapeutics development. Currently, most labs custom-build their plasmids. As yet, no s

Friends don’t use friend’s plasmids without sequencing them. For some types of plasmids from academic and industrial labs, up to 40% contained mutations academic.oup.com/nar/article/...

Villum Foundation wishes to encourage the exchange of scientific ideas between the US and Denmark. Villum Sabbatical supports research stays of up to one year at a Danish university. Researchers at the associate professor or professor level based at a US university may receive up to 1 MDKK to cover their salary (in part or in full), salary of accompanying group members (postdocs and PhD students), travel and research costs associated with the stay. Applications are only accepted from the head of the department at the Danish host institution. If a visiting researcher subsequently decides to relocate to Denmark, they are encouraged to apply for one of Villum Foundations’s investigator grants (Young Investigator, Ascending Investigator, Investigator)

Villum Sabbatical grant:

For US-based researchers wishing to visit a Danish university for up to 12 months

Deadline Aug. 15th 2025

villumfonden.dk/en/group/cha...

🚨 One week left to apply!
I am hiring a fully funded PhD fellow and a postdoc to work on membrane protein structural biology and pharmacology at Univ Copenhagen

Come work with a great team and exciting projects in a collaborative environment!

🔗 Links to the ads in comments

#CryoEM #AcademicJobs

@michaelclerx.com et al. @uniofnottingham.bsky.social present variability in reported midpoints of activation and inactivation for the cardiac fast sodium current, INa, show the correlation between these midpoints, and discuss possible experimental sources of variability. rupress.org/jgp/article/...

164291 Associate Professor or Professor

We are hiring at the Department of Drug Design and Pharmacology.
Check out these opportunities and consider becoming our new colleague at University of Copenhagen.

employment.ku.dk/faculty/?sho...

Thank you, Yamuna

We are very grateful to the many contributors, incl our fantastic collaborators in the Lundby, Wellendorph & Schramek groups. Special thanks to Nadine Ritter for her copious patch-clamp contributions.
This collaborative effort funded from the @lundbeckfonden.bsky.social and DFF.

“It’s the company that matters!”

This is certainly true for acid-sensing ion channel 1a, whose function is modulated by the presence of monocarboxylate transporter 1

All was made possible by the drive & curiosity of the fantastic @mette-h-poulsen.bsky.social

www.biorxiv.org/cgi/content/...

A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)

Exciting news for protein design!

I guess I should re-post from the Bird Site "The Rules For Academic Success here":

I always get asked for advice about starting/surviving the tenure track. Here are the rules I've found useful. Thought I'd put it out there for the masses...

This list gets longer all the time

sorry to hear, but sadly not uncommon. same thing happened to us in Australia, Canada and Denmark - basically had to start by building credit using a debit card for a while every time...(which meant even in a tenured position I couldn't hire a car, haha)

Congratulations!

The 3rd Berlin Single Molecule Biophysics Course will run from 8th to 12th September at the HU-Berlin, Institute of Biology.
Learn about single channels, single molecule TIRF, theory and analysis. Apply by 7th July at bsmbc@icloud.com. Fee waivers and bursaries available.

! Please share widely !