PlessLab

🚨 One week left to apply!
I am hiring a fully funded PhD fellow and a postdoc to work on membrane protein structural biology and pharmacology at Univ Copenhagen

Come work with a great team and exciting projects in a collaborative environment!

🔗 Links to the ads in comments

#CryoEM #AcademicJobs

@michaelclerx.com et al. @uniofnottingham.bsky.social present variability in reported midpoints of activation and inactivation for the cardiac fast sodium current, INa, show the correlation between these midpoints, and discuss possible experimental sources of variability. rupress.org/jgp/article/...

164291 Associate Professor or Professor

We are hiring at the Department of Drug Design and Pharmacology.
Check out these opportunities and consider becoming our new colleague at University of Copenhagen.

employment.ku.dk/faculty/?sho...

Thank you, Yamuna

We are very grateful to the many contributors, incl our fantastic collaborators in the Lundby, Wellendorph & Schramek groups. Special thanks to Nadine Ritter for her copious patch-clamp contributions.
This collaborative effort funded from the @lundbeckfonden.bsky.social and DFF.

“It’s the company that matters!”

This is certainly true for acid-sensing ion channel 1a, whose function is modulated by the presence of monocarboxylate transporter 1

All was made possible by the drive & curiosity of the fantastic @mette-h-poulsen.bsky.social

www.biorxiv.org/cgi/content/...

A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)

Exciting news for protein design!

I guess I should re-post from the Bird Site "The Rules For Academic Success here":

I always get asked for advice about starting/surviving the tenure track. Here are the rules I've found useful. Thought I'd put it out there for the masses...

This list gets longer all the time

sorry to hear, but sadly not uncommon. same thing happened to us in Australia, Canada and Denmark - basically had to start by building credit using a debit card for a while every time...(which meant even in a tenured position I couldn't hire a car, haha)

Congratulations!

The 3rd Berlin Single Molecule Biophysics Course will run from 8th to 12th September at the HU-Berlin, Institute of Biology.
Learn about single channels, single molecule TIRF, theory and analysis. Apply by 7th July at bsmbc@icloud.com. Fee waivers and bursaries available.

! Please share widely !

ASIC 2025 Meeting - Wissenschaftliches Treffen über ASICs Erleben Sie die neuesten Fortschritte in der ASIC-Forschung beim ASIC 2025 Meeting in Tutzing.

Great meeting on acid-sensing ion channels coming up in the fall in Germany - make sure to sign up:

www.asic-meeting.org

Thank you so much for including me in your exciting event!

🧵5 Top Free Alternatives to BioRender for Scientific Illustrations!

These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.

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CCeMMP Seminar alert⏰ We welcome Professor Juan Du, Department of Molecular Biosciences, Northwestern University, Illinois, USA!
“The importance of Physiological Temperature in Biomedical & Biophysical Research”
More details and register:
ccemmp.org/events/ccemm...

Very important to keep in mind: Asp/Glu aren’t necessarily always charged!

Heard from a former (undergrad) student who just defended her PhD. Students: tell your old profs about your successes and achievements. It's not bragging, and we love to hear about it. It's one of the best parts of being an educator.
#academicsky

Structural insights into allosteric mechanism of glycine transporter-mediated analgesia Chronic neuropathic pain, caused by nerve damage or disease, affects 10% of the population with rising incidence. The burden is exacerbated by ineffective treatments and overreliance on opioids. Neuro...

Beyond excited to present our study on the glycine transporter #GlyT2, a promising #non-opioid target for the treatment of neuropathic pain.
@biorxivpreprint.bsky.social

www.biorxiv.org/content/10.1...

Save the date!!!
For the first time since 2015, the annual conference of the International Chemical Biology Society comes back to Europe and joins forces with the biennal European Chemical Biology Symposium, to organize #ChemBioParis2025, in the heart of the City of Light.
Oct 6-9, 2025.

Congratulations to everyone involved!

Structural basis for selective inhibition of human GABA transporter GAT3 https://www.biorxiv.org/content/10.1101/2025.03.27.645797v1

Stellar line up for our protein design conference. Copenhagen, Sept 1-4, 2025. 10 days to abstract deadline. Get applying! benzon-foundation.dk/benzon-sympo...

⏰ Two weeks left to register for our Benzon Symposium on Protein structure prediction and design 🧶🧬🖥️

Meeting will take place in Copenhagen 🇩🇰 on Sept. 1–4, 2025, and will feature an amazing list of speakers 👨‍🔬👩‍🔬👩‍💻👨‍💻

Submit your application via:
benzon-foundation.dk/benzon-sympo...

Finally, we would like to express our gratitude to @lundbeckfonden.bsky.social for their support of our work

Thanks to an epic effort by Estelle Toulme and the rest of the Christian Rosenmund lab we were then able to show that the interaction also plays a physiological role in neurons - and that NALCN may be the molecular culprit of the neuronal death which occurs when syntaxin is removed from the cell...

@alexshauser.bsky.social helped with the computational screen, while @rflorea.bsky.social and Alexander Leitner @ETH, and Marc Kschonsak and his team at @genentech.bsky.social spearheaded the biochemical complementation of our in vitro electrophysiology.

The study was initiated and led by @samuel.bsky.team, who developed a bioinformatics approach that implicated SNARE proteins as potential interaction partners of the NALCN complex.

Our latest paper on the sodium leak channel NALCN complex is now online. We found that the neuronal SNARE proteins syntaxin 1A and SNAP25 inhibit sodium leak currents both in heterologous systems and in neurons!

www.science.org/doi/10.1126/...

Labeling your axes and then explaining them slowly is perhaps the biggest bang for the buck you can get for making your slides more understandable.